2 research outputs found
Optimisation of the Manufacturing Process of Organic-Solvent-Free Omeprazole Enteric Pellets for the Paediatric Population: Full Factorial Design
Liquid formulations are mostly used in the paediatric population. However, with certain active pharmaceutical ingredients (APIs), it is very difficult to guarantee quality and stability; this is the case, for example, with omeprazole. Omeprazole is used as a model drug due to the lack of a paediatric formulation meeting gastro-resistance requirements, which remains a challenge today. In this experimental study, the development of enteric polymer-coated pellets is proposed. It is proposed to use aqueous coating dispersions without the use of organic solvents, which are commonly used in fluidised bed coatings. To do this, the design of experiments method is used as a statistical tool for experiment creation and the subsequent analysis of the responses. In particular, this study uses a randomised full factorial design. The mean weight increases of the protective layer and the enteric coating are chosen as factors. Each factor is assigned two levels. Therefore, the design of the used experiments is a 22 + 1 central point. Overall, the obtained pellets can be an alternative to the compounding formulas of omeprazole that are currently used in the paediatric population, which do not meet the gastro-resistance specifications necessary to guarantee the therapeutic efficacy of this active ingredient
Jardins per a la salut
Facultat de FarmĂ cia, Universitat de Barcelona. Ensenyament: Grau de FarmĂ cia. Assignatura: BotĂ nica farmacĂšutica. Curs: 2014-2015. Coordinadors: Joan Simon, CĂšsar BlanchĂ© i Maria Bosch.Els materials que aquĂ es presenten sĂłn el recull de les fitxes botĂ niques de 128 espĂšcies presents en el JardĂ Ferran Soldevila de lâEdifici HistĂČric de la UB. Els treballs han estat realitzats manera individual per part dels estudiants dels grups M-3 i T-1 de lâassignatura BotĂ nica FarmacĂšutica durant els mesos de febrer a maig del curs 2014-15 com a resultat final del Projecte dâInnovaciĂł Docent «Jardins per a la salut: aprenentatge servei a BotĂ nica farmacĂšutica» (codi 2014PID-UB/054). Tots els treballs sâhan dut a terme a travĂ©s de la plataforma de GoogleDocs i han estat tutoritzats pels professors de lâassignatura. Lâobjectiu principal de lâactivitat ha estat fomentar lâaprenentatge autĂČnom i col·laboratiu en BotĂ nica farmacĂšutica. TambĂ© sâha pretĂšs motivar els estudiants a travĂ©s del retorn de part del seu esforç a la societat a travĂ©s dâuna experiĂšncia dâAprenentatge-Servei, deixant disponible finalment el treball dels estudiants per a poder ser consultable a travĂ©s dâuna Web pĂșblica amb la possibilitat de poder-ho fer in-situ en el propi jardĂ mitjançant codis QR amb un smartphone