Genome-wide plot of the GENEHUNTER-MODSCORE results for the microsatellite markers using the sex-specific map

<p><b>Copyright information:</b></p><p>Taken from "Linkage analysis of alcohol dependence using MOD scores"</p><p></p><p>BMC Genetics 2005;6(Suppl 1):S162-S162.</p><p>Published online 30 Dec 2005</p><p>PMCID:PMC1866771.</p><p></p> The red graph shows the MOD scores obtained under four-penetrance trait models that take imprinting into account, and the blue graph shows the MOD scores obtained under the nonimprinting constraint

Genome-wide plot of the GENEHUNTER-MODSCORE results for the Affymetrix SNP markers

<p><b>Copyright information:</b></p><p>Taken from "Linkage analysis of alcohol dependence using MOD scores"</p><p></p><p>BMC Genetics 2005;6(Suppl 1):S162-S162.</p><p>Published online 30 Dec 2005</p><p>PMCID:PMC1866771.</p><p></p> The red graph shows the MOD scores obtained under four-penetrance trait models which take imprinting into account, and the blue graph shows the MOD scores obtained under the nonimprinting constraint. Here, a sex-averaged map has been used

Cross-twin correlations and heritability estimates of hearing traits.

<p>For all three hearing traits—pure tone thresholds (A), otoacoustic emission reproducibility (B), and otoacoustic emission strength (C)—cross-twin correlations were higher in MZ than in DZ twins, and very high heritability values could be estimated. <i>r</i>, intra-class correlation; <i>h²</i>, heritability estimate; 95% confidence interval in brackets; AE, preferred model used to estimate heritability.</p

Cross-twin correlations and heritability estimates of baroreflex traits.

<p>For both baroreflex traits—baroreflex sequence slope (A) and baroreflex sequence frequency (B)—the cross-twin correlations were higher in MZ than in DZ twins. Significant heritability estimates could be calculated. <i>r</i>, intra-class correlation; <i>h²</i>, heritability estimate; 95% confidence interval in brackets; AE, preferred model used to estimate heritability.</p

Cross-correlations between the investigated sensory traits.

<p>Three different types of intramodal and intermodal correlations were distinguished (A). Three mechanosensory and one non-mechanosensory intermodal correlation were detected (B). ^ns, not significant; * <i>p</i><0.05; ** <i>p</i><0.01; *** <i>p</i><0.001. False discovery rates for <i>p</i> value cutoff at 0.05 for (1) intramodal correlations: 0.004, (2) mechanosensory intermodal correlations: 0.14, and (3) non-mechanosensory intermodal correlations: 0.83. Values were corrected for age before analysis.</p

Touch sensitivity in a cohort of Braille reading blind people.

<p>The vibration detection threshold was not different in comparison to a control cohort, but the tactile acuity was significantly higher in the blind cohort. *** <i>p</i><0.001; <i>t</i> test.</p

Touch sensitivity in different cohorts of people suffering from the Usher syndrome.

<p>The mean tactile acuity and vibration detection thresholds were elevated in the group of people carrying pathogenic mutations in the gene USH2A (A, B) but not in a cohort of Usher syndrome type II patients with unknown genotype where tactile acuity thresholds were lower than in the control cohort (D), and vibration detection thresholds were not significantly different (C). ^ns, not significant; * <i>p</i><0.05 Student's <i>t</i> test.</p

Summary of psychophysical and physiological tests carried out in different cohorts.

<p>Summary of psychophysical and physiological tests carried out in different cohorts.</p

Cross-twin correlations and heritability estimates (where applicable) of temperature sensitivity traits.

<p>For all traits except the cold pain threshold, the cross-twin correlations were higher in MZ than in DZ twins. Significant heritability estimates could be calculated for cold (A) and warmth (B) detection thresholds, whereas for the heat (C) and cold (D) pain thresholds, the CE model, not containing a heritable component, was preferred. <i>r</i>, intra-class correlation; <i>h²</i>, heritability estimate; 95% confidence interval in brackets; AE/CE, preferred model used to estimate heritability.</p

Cross-twin correlations and heritability estimates of touch sensitivity traits.

<p>For both vibration detection threshold (A) and tactile acuity (B) cross-twin correlations were higher in monozygotic (MZ) than in dizygotic (DZ) twins and significant heritability values could be estimated. <i>r</i>, intra-class correlation; <i>h²</i>, heritability estimate; 95% confidence interval in brackets; AE, preferred model used to estimate heritability.</p