Skeeter Buster: A Stochastic, Spatially Explicit Modeling Tool for Studying Aedes aegypti Population Replacement and Population Suppression Strategies

Dengue is a viral disease that affects approximately 50 million people annually, and is estimated to result in 12,500 fatalities. Dengue viruses are vectored by mosquitoes, predominantly by the species Aedes aegypti. Because there is currently no vaccine or specific treatment, the only available strategy to reduce dengue transmission is to control the populations of these mosquitoes. This can be achieved by traditional approaches such as insecticides, or by recently developed genetic methods that propose the release of mosquitoes genetically engineered to be unable to transmit dengue viruses. The expected outcome of different control strategies can be compared by simulating the population dynamics and genetics of mosquitoes at a given location. Development of optimal control strategies can then be guided by the modeling approach. To that end, we introduce a new modeling tool called Skeeter Buster. This model describes the dynamics and the genetics of Ae. aegypti populations at a very fine scale, simulating the contents of individual houses, and even the individual water-holding containers in which mosquito larvae reside. Skeeter Buster can be used to compare the predicted outcomes of multiple control strategies, traditional or genetic, making it an important tool in the fight against dengue

Kinetics of [125I]insulin distribution in subcellular fractions from rabbit kidney

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Apparition prècoce de nuclèoles anormaux, au cours de la segmentation, dans des embryons de pleurodéle traitès par la cycloheximide. Ètude ultrastructurale des diffèrents corps nuclèolaires prèsents dans des embryons tèmoins et traitès

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Effets de la puromycine sur la mitose, la synthèse des protéines et celle du DNA au cours de la segmentation de l'oeuf de batracien

Journal Articleinfo:eu-repo/semantics/publishe

Competitive effect of insulin and ouabain on metabolism of acetabularia mediterranea

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Use of liposome-associated bupivacaine in a cancer pain syndrome

Bupivacaine 0.25% encapsulated by multilamellar liposomes was administrated epidurally to a patient suffering pain associated with lung cancer and the effect compared with a plain bupivacaine solution of the same concentration. Complete analgesia was produced for 4 h with the plain solution and 11 h with the liposomal formulation. No motor blockade or haemodynamic instability was observed with the liposome-associated bupivacaine.SCOPUS: ar.jFLWINinfo:eu-repo/semantics/publishe

Fixation spécifique d'insuline a des chloroplastes isoles d'acétabularia mediterranea

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α-Melancoyte-stimulating hormone binding and biological activity in a human melanoma cell line

Synthetic α-melanocyte-stimulating hormone (α-MSH) was found to bind to the plasma membrane of the HM6A human melanoma cell line, using an immunocytochemical method. When treated with 10-7 to 10-9 M α-MSH, melanoma cells exhibited an increase of intracellular cyclic adenosine 3':5'-monophosphate, followed by stimulation of tyrosinase activity. Significant inhibiton of DNA synthesis measured by [3H]thymidine uptake and inhibition of cell growth was found. A retrovirus expression was detected in the supernatant of HM6A cells as assayed by the KC cell syncytium-forming test. In the presence of 10-7 M α-MSH, the number of syncytium-forming units was increased 15-fold. These results demonstrate that α-MSH modulates human melanoma differentiation and virus expression in vitro.SCOPUS: NotDefined.jinfo:eu-repo/semantics/publishe

Plasma concentrations of bupivacaine after brachial plexus administration of liposome-associated and plain solutions to rabbits

Bupivacaine has been associated to multilamellar liposomes with the aim of altering circulating plasma concentrations after injection into the rabbit brachial plexus. Plasma concentrations of bupivacaine have been compared after administration of free drug (BP) or bupivacaine associated to multilamellar liposomes (BP-MLV) made of phosphatidylcholine and cholesterol (molar ratio 4:3). Under light general anaesthesia, one group of six rabbits received an axillary injection of 2.5 mg BP (1 ml, 0.25%), and a second received the same dose of BP-MLV. In both groups3H bupivacaine was used as a marker. The brachial plexus was located using a nerve stimulator. Injection of the anaesthetic solutions invariably prevented the motor response of the paw. The arterial plasma concentrations of bupivacaine were determined after 5 to 240 min and after 24 hr by beta counting. In the MLV population, additional measurements were performed after 48 and 72 hr. The two plasma curves showed a plateau (0.2 μg · ml-1) which was reached after five minutes in the BP group and after 90 min using BP-MLV In the BP-MLV group, the plasma concentrations of bupivacaine were lower during the first ten minutes (P < 0.05), and higher after 24 hr (P < 0.05). Radioactivity decreased between 4 and 24 hr in the BP group and between one and two days in the BP-MLV population. It is concluded that elevated plasma drug concentrations were maintained for longer with BP-MLV than with BP This could prolong the action of the local anaesthetic through a slow release. © 1993 Canadian Anesthesiologists.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Immunohistochemical-autoradiographic studies of porcine and human 125I-insulin hepatic binding and internalization in vivo

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