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Additional file 10: Figure S1. RNAseq data validation by RT-qPCR. The values are mean ± SEM (n = 3/group for RNA-Seq, n = 8/group for RT-qPCR)

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Additional file 4: Table S4. List of genes in Venn diagram in Fig. 3

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Additional file 7: Table S7. The list of the references for genes linked to HIF-1 signalling by manual literature search

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Additional file 1: Table S1. Primer sequences for RT-qPCR

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Additional file 2: Table S2. Basal left ventricular echocardiographic parameters, heart rate, and body weight of the offspring

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Additional file 12: Figure S3. PECAM-1 expression in the LV. Representative images of staining of PECAM-1 (red) with Hoechst stained cell nuclei (blue) in the LV of 12 week-old offspring (a-d). Scale bar = 50 μm. e-h: Delineated PECAM+ area in the myocardium using Adobe Photoshop. Quantification of PECAM-1 staining determined as a percentage of positive area in the field of view by ImageJ (i). The values are mean ± SEM (n = 4). Statistical significance assessed by two-way ANOVA: genotype effect P = 0.0302, followed by post hoc Tukey’s multiple-comparison test with no significant result

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Additional file 8: Table S8. Bioinformatics enrichment analysis using gProfiler: g:GOST Gene Group Functional Profiling tool

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Additional file 9: Table S9. Bioinformatics mammalian phenotype ontology enrichment analysis using MouseMine Analysis Tools

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Additional file 6: Table S6. The list of HIF-1 signaling target genes

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Additional file 11: Figure S2. Quantification of TUNEL+ apoptotic cells per mm2 of the RV myocardium (a) and septum (b). The values are mean ± SEM (n = 4 individuals/3 sections/group). Two-way ANOVA indicating a significant effect of diabetes (RV: P < 0.0001; septum: P < 0.0001) followed by post hoc Tukey’s multiple-comparison test, **P < 0.01, ***P < 0.001, **** P < 0.0001