5 research outputs found
Personality profiles of dysthymic disorder.
A Dissertation submitted to the Faculty of Medicine in
part fulfilment of the requirements for the Degree of
Master of Medicine in Psychiatry at the University of the
Witwatersrand.The motivation for undertaking this study stems from the
confusion that reigns in the literature regarding the
relationship between personality, personality traits and
dysthymic disorder. A large body of theorists ancl
researchers still claim a definite association between
dysthymia and personality. Their views arose to an
extent from the concept of dysthymia as it developed
through the past few decades. Dysthymia grew out of the
concept of depressive neurosis which had a stronger basis
in personality pathology. other terms like neurotic
depression and depressive reaction preceded depressive
neurosis.
with the advent of DSM-III and DSM-III-R, dysthymia was
moved from the neuroses to the mood disorders category.
The DSM-IV Mood Disorders Work Group has also reinforced
the classification of dysthymia with mood disorders.
The Work Group has embarked on research to determine the
symptomatology that should be used for the diagnosis of
dysthymia. It is proposed that cognitive, functional and
vegetative symptoms be included in DSM-IV to further
entrench dysthymia as an affective disorder and
extricate it from the personality disorders.Andrew Chakane 201
The intercontinental schizophrenia outpatient health outcomes (IC-SOHO) study: baseline clinical and functional characteristics and antipsychotic use patterns in the North Africa and Middle Eastern (AMEA) region: original article
Objective: To describe the baseline findings of the Intercontinental Schizophrenia Outpatient Health Outcomes (IC-SOHO) study in the North Africa and Middle Eastern sub-region (AMEA-SOHO)
Method: The IC-SOHO study is an ongoing prospective, three-year, non-interventional observational study of schizophrenia treatment, clinical characteristics and mental health services utilization in two North African and two Middle Eastern countries. The study population consists of non-hospitalised patients who had initiated treatment with or changed to a new antipsychotic.
Results: The baseline findings of the IC-SOHO study (AMEA Subset) appear to reflect clinical practice in Turkey, Saudi Arabia, Egypt and Algeria (N=1, 398). Overall, the patients were moderately to markedly ill and either overweight (46%) or obese (8%) when they entered the study. Functionally, the majority of patients were not involved in social activities, could not care for themselves and were unemployed. Substance and alcohol dependency/abuse was not a problem in this study population. At baseline the majority of patients were treated with typical antipsychotics (oral and depot); and anticholinergics were the most commonly prescribed concomitant medication. Sexual side effects were most frequently reported among the surveyed adverse events. Overall compliance/adherence to medication was good.
Conclusion: The baseline IC-SOHO data highlighted various clinical and functional characteristics and antipsychotic use patterns in a group of outpatients with schizophrenia in a naturalistic setting. Once completed, the IC-SOHO study will add further to this knowledge base.
SA Psychiatry Rev. Vol.7(3) 2004: 27-3
The Intercontinental Schizophrenia Outpatient Health Outcomes (IC-SOHO) study: baseline clinical and functional characteristics and antipsychotic use patterns in Turkey
Objective: In this study, our main objective is to describe the baseline findings of the Intercontinental Schizophrenia Outpatient Health Outcomes(IC-SOHO) study in Turkey.Method: The IC-SOHO study is an ongoing prospective, three-year non-interventional observational study of schizophrenia treatment, clinicalcharacteristics and mental health services utilization in Turkey. The study population consisted of non-hospitalized patients who had started orswitched into a new antipsychotic.Results: The baseline findings of the IC-SOHO study (Turkish Subset) appear to reflect clinical features of schizophrenia patients in Turkey (n=692).Overall the patients were moderately to markedly ill (66.7%) and already overweight (46.4%) and obese (7.3%) when they entered the study.Functionally the majority of patients were not involved in social activities, could not care for themselves and were unemployed. Substance andalcohol dependency/abuse was not a major problem in this study population. The majority of patients at baseline were treated with anantipsychotic (86.1%) and oral typicals antipsychotics were the most commonly used drugs 6 months prior to the study. Sexual adverse events werethe most frequently reported amongst the surveyed adverse events and overall compliance/adherence was moderate.Conclusion: The baseline IC-SOHO findings highlighted various clinical and functional characteristics and antipsychotic use patterns in a group ofschizophrenic outpatients in a naturalistic setting in Turkey. Once completed, the IC-SOHO study will add further information to this knowledge base
Depression in the South African workplace
Depression is a common psychiatric disorder and can be costly, having a significant impact on the individual and employers. The South African Depression and Anxiety Group (SADAG) in partnership with HEXOR, with the support of Lundbeck, undertook research into depression in the workplace, because South African information is not available on this topic. It provides insight into the prevalence of depression within the workplace in South Africa, as well as the impact of depression on the employees and employers in terms of sick leave and levels of productivity, especially when the symptoms include cognitive impairment. It is apparent that stigma plays a pivotal role in the reasons for non-disclosure to employers. It further highlights the magnitude of awareness, early detection and the provision of a holistic support system within the work environment, free from bias, to ensure that optimum benefit can be achieved for both employer and employee
Psychopharmacology 2003 Conference, 10-13 September 2003
List of abstracts and authors:
1. Comparative benefits of Atypical antipsychotics
Diana P Morrison
2. Evidence-based management of depression in Schizophrenia
Andre F Joubert
3. Second generation Antipsychotics: An African update
Dave Swingler
4. The drug management of patients with HIV/Aids in the Mental Health Care setting: A therapeutic challenge
Denise White
5. New developments in the treatment of Bipolar depression
Jospeh R Calabrese
6. Dual action antidepressants: Faster onset, more remission, better value?
Roger M Pinder
7. Antisocial personality disorder: A review
Donald W Black
8. The South African study of stress and health: An overview
David R Williams
9. Ugliness is in the eye of the beholder: Psychiatric apsects of body image disturbance
David Castle
10. Over diagnosed or under recognized? Treating ADHD
Dora Wynchank
11. The contagious effects of trauma and their impact on human service organisations
Kerry Gibson
12. Temporal lobe epilepsy in adolescence - 'Understanding the narrative'
Helen Clark
13. The effectiveness of treatment programs for Methaqualone (Mandrax) dependence
Greg McCarthy, Nandi Siegfried, Bronwyn Myers
14. Community influence on alcohol and marijuana
Alan J Flisher, Robyn Mallett, Gary King, Neo Morojele, Martie Muller, Carl Lombard
15. Psychiatric presentations of medical illness
Sebastian Akalula
16. Imaging of brain function using Spect
James Warwick
17. Selected neuropsychological test performances and SSRI usage
Theophilus Lazarus
18. Comparative effectiveness and safety of antipsychotic treatments for outpatient Schizophrenia
Frans Korb, Adel Sadak, Aly Akram, Sunar Birsoz, Abderrahmane Belaid
19. Evidence-based mental healthcare - What do you know, think, feel?
Nandi Siegfried, George Swingler, Soraya Seedat, Martie Muller, Rachel Churchill, Dan Stein
20. Competitions Act - Anti-competitive health care practices
Z Nthakwana
21. Unique approach to mental wellness by medical Schemes
Petro Kempen
22. What happens to my medical aid contribution?
Eugene Allers
23. Financial issues in a modern private practice
Mike Edwards
24. Transcranial magnetic stimulation: Uses in brain function research and medical intervention
Alan St Clair Gibson
25. The Neurochemistry of dreams: Implications for Psychiatry
Mark Solms
26. Tenascin-R expression in the Central Nervvous system of lower vertebrates
Ruth Jarvis, N-. Hsu, P. Pesheva and D.M. Lang
25. Localisation of the Nogo-A receptor in Neronal Lipid rafts
Edward Nyatia, D.M. Lang
26. Characterising an animal model for early life trauma using time dependent sensitisation
Joachim D.K. Uys, Willie M.U. Daniels, Dan J. Stein
27. Tolmetin affords protection against Quinoclinic acid induced Neurotoxixity in Rat brain
Amichand Dairam, S Daya
28. Acetaminophen and aspirin inhibit superoxide anion generation and Lipid Peroxidation, and protect against 1-Methyl-4Phenyl Pyridinim-induced Dopaminergic Neurotoxicity in rats
H. Maharaj, D.S. Maharaj, K. S. Saravanan, K.P. Mohanakumar, S. Daya
29. Can exercise provide Neuroprotection in a rat model for Parkinson's disease?
M Mabandla, L Kellaway, A St Clair Gibson, M Lambert, V Russell
30. Treatment of rapid cycling Bipolar disorder
Joseph R. Calabrese
31. Depression as a Neurodegenerative Disorder: The need for achieving remission
Roger M Pinder
32. Side-effects induced by modern antidepressants- Overview and management
Franco Colin
33. The Placebo response in antidepressant clinical trials
Robin Emsley
34. Impulse control disorders: An overview
Donald W. Black
35. Post traumatic stress disorder: The Wits trauma clinic experience
Ugash Subramaney
36. Post traumatic stress disorder among recently diagnosed patients with HIV in South Africa
Soraya Seedat, Bo Olley, D J Stein
37. Improving outcome in Schizophrenia
Diana P Morrison
38. Reviewing post Graduate training
Cliff W Allwood
39. Ethics in HIV Research
Keimanthro Moodley
40. Improving and maintaining ethical standrads in Psychiatric research
Tuviah Zabow
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Posters: Neurosciences section (Presenting author only)
1. Blunted Acth response correlates with altered Neurotransmitter function in maternally separatedrats
W M U Daniels
2. A mechanism for zinc toxicity in Neuroblastoma cells
W M U Daniels
3. The effects of Hypericum Perforatum, Quercetin, and Fluoxetine on receptor densities in the Rat Brain
L Heiderman
4. Trichotillomania and obsessive-compulsive disorder: Clinical and genetic comparisons within a South African population
S M J Hemmings
5. Expression of Nogo-A in the amphibian central nervous system
N. J. Hsu
6. Biochemical model for inflammation of the brain: The role of iron, transferring and toxiferring in Lipid Peroxidation
S J Van Rensburg
7. Improvement in Alzheimer's disease patients with antioxidant supplementation over 15 months
S J Van Rensburg
8. The Placebo effect - Is it all in the mind?
S J Van Rensburg
9. Very low serum iron concentrations in elderly patients with active Carcinoma
S J van Rensburg
10. Melatonin affords protection against Rotenone-induced Neurotoxicity
R John
11. Effect of enriched environment on Ca uptake via NMDA receptors into barrel cortex slices of spontaneously Hypertensiverats
M Lehohla
12. Effects of Methylpenidate in a rat model for Attention Deficit Hyperactivity Disorder
G. L. S. Lelaka
13. 6-Hydroxymelatonin converts Fe (III) to Fe(II) and reduces iron-induced Lipid Peroxidation
D S Maharaj
14. Metrofinate Potentiates Quinolinic Acid and Potassium Cyanide induced Neurotoxicity
A Ramsunder
15. The effect of chronic Intra-Amylgdala CRF injections on rat behaviour and HPA-Axis function
L Richter
16. Effect of Glutamate in the Prefrontal Cortex of a rat model for Attention-Deficit Hyperactivity Disorder
V Russell
17. An investigation into the relationship between Corticosterone and Neuron Cell death
P J Van Vuuren
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41. Blunted Acth response correlates with altered Neurotransmitter function in maternally separated Rats
W M U Daniels, C Y Pietersen, M E Carstens, D J Stein
42. A mechanism for Zinc Toxicity in NeuroBlastoma Cells
W M U Daniels, J Hendricks, R Salie, S J Van Rensburg
43. The effects of Hypericum Perforatum, Quercetin and Fluoxetine on receptor densities in the rat brain
L Heideman and S Daya
44. Trichotillomania and obsessive-compulsive disorder: Clinical and genetic comparisons withn a South African population
S M J Hemmings, C J Kinnear, C Lochner, H Moolman-Smook, D J H Niehaus, V Corfield, D J Stein
45. Expression of Nogo-A in the amphibian central nervous system
N. J. Hsu, R Jarvis, D. M. Lang
46. Biochemical model for inflammation of the brain: The role of iron, transferring and Toxiferring in Lipid Peroxidation
S J Van Rensburg, R T Erasmus, J M van Zyl, D Hon, W M U Daniels, F C V Potocnik, M J Kotze, N J De Villiers, P R Hurly
47. Improvement in Alzheimer's Disease patients with antioxidant supplementation over 15 months
S J van Rensburg, F C V Potocnik, J M Van Zyl, B J Van der Walt, D Hon, A Roos, E Rienhardt, R T Erasmus
48. The Placebo effect - Is it all in the mind?
S J van Rensburg, R A Emsley, C M Smuts, M Kidd, S Van der Merwe, C C Myburgh, P Oosthuizen, H Bleeker
49. Very low serum Iron concentrations in elderly patients with active Carcinoma
S J van Rensburg, R Erasmus, D Hon, C Bouwens
50. Melatonin affords protection against Rotenone-induced Neurotoxicity
R John, S Daya
51. Effect of enriched environment on Ca uptake via NMDA Receptors into barrel Cortex slices of spontaneously Hypertensive rats
M Lehohla, V Russell, L Kellaway
52. Effects of Methylpenidate in a rat model for Attention-Deficit Hyperactivity Disorder
G. L. S. Lelaka, V. A. Russel, L. A. Kellaway
53. 6-Hydroxymelatonin converts Fe (III) to Fe (II) and reduces iron-induced Lipid Peroxidation
D S Maharaj, S Daya
54. Metrofinate Potentiates Quinolinic Acid and Potassium Cyanide induced Neurotoxicity
A Ramsunder, S Daya
55. The effect of chronic Intra-Amygdala CRF injections on rat behaviour and HPA-Axis function
L Richter, W Daniels, D J Stein
56. Effect of Glutamate in the Prefrontal Cortex of a rat model for Attention-Deficit Hyperactivity Disorder
V Russell, M Lehohla, L Kellaway
57. An investigation into the relationship between Corticosterone and Neuron cell death
P J Van Vuuren, J Hendricks, W M U Daniels
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Posters: Psychiatry Section
1. Descriptive study of Tardive Dyskinesia in a South African Xhosa population
S Brink
2. Alcohol drinking problems at three urban High Schools in Umtata
O Alonso Betancourt
3. Childhood and adolescent sexual abuse - Demographic, traumatic and clinical signposts
P D Carey
4. Inositol in the treatment of Obsessive Compulsive Disorder
P D Carey
5. A review of factors associated with Suicidal behaviour in children and adolescents admitted to Tygerberg Hospital
T Du Plessis
6. Psychological and physical outcomes fo elective abortion; Local Anaesthesia vs Intravenous Sedation
T Ericksen
7. Mental health literacy of Human Resource Practitioners in South Africa
C J Hugo
8. The importance of a specialized clinic for the care of patients with first episodes of psychosis
N Keyter
9. Self-report vs Urinary drug screening in Schizophrenia: A pilot study
L Koen
10. The effect of aggression on the use of Psychotropics in Schizophrenia: A naturalistic study
H Lategan
11. Factor analysis of obsessive-compulsive spectrum disorders in patients with obssessive-compulsive disorder: Clinical and Genetic correlates
C Lochner
12. Experiences in obsessive-compulsive Disorder and Trichotillomania: Role of childhood trauma
C Lochner
13. Delusional systems in Xhosa Schizophrenia Sibpairs
J E Muller
14. OCD Heteogeneity reflected by lack of Genealogically determined founder effect
D J H Niehaus
15. The efficacy and tolerbaility of low-dose vs standard dose Haloperidol in first episode Psychosis. A randomised, double-blind study
P P Oosthuizen
16. Treatment with low-dose Haloperidol does not protect against Tardive Dyskinesia
P P Oosthuizen
17. Do healthcare funders discriminate against members on the grounds of mental illness?
O Scholtz
18. Treatment strategies in patients with Clozaopine-resistant Schizophrenia at Stikland Hospital: A critical evaluation of one option
A Schulte
19. Early coadministration of Clonazepam with Paroxetine for generalized social anxiety disorder
S Seedat
20. Trauma exposure and post-traumatic stress symptoms in adolescents: A schools' survey in Cape Town (South Africa) and Nairobi (Kenya)
S Seedat
21. The QTC effects of Thioridazine when used as a second line Anti-psychotic ( at Stikland Hospital)
C Seller
22. Brain imaging and substance related disorders
D J Stein
23. Gender differences in trauma exposure & post traumatic stress disorder in a clinic sample
S Suliman
24. Assessing the prevalence of anxiety and depressive symptoms among clinica at Tygerbeg Academic Hospital and controls
H Van der Bijl
25. Pharmacological challenge with a serotonin ID Agonist in alcohol dependence
B Vythilingum
26. The treatment of ADHD in adults
W Verbeeck
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58. Descriptive study of Tardive Dyskinesia in a South African Xhosa population
S Brink, D J H Niehaus, L Koen, J E Muller
59. Alcohol drinking problems at three Urban High Schools in Umtata
O Alonso Betancourt, M Morales Herrera
60. Childhood and adolescent sexual abuse - Demographic, traumatic and clinical signposts
P D Carey, J Walker, S Seedat, D J Stein
61. Inositol in the treatment of obsessive compulsive Disorder
P D Carey, S Seedat, D J Stein
62. A review of factors associated with suicidal behaviour in children and adolescents admitted to Tygerberg Hospital
T Du Plessis, S M Hawkridge, F H Theron, S A Du Plessis
63. Psychological and physical outcomes of elective abortion: Local anaestheisa vs Intravenous sedation
T Ericksen, S Seedat, P Labuschagne, D J Stein
64. Mental health literacy of Human resource practitioners in South Africa
C J Hugo, H D Vos, D J Stein
65. The importance of a specialized clinic for the care of patients with first episodes of psychosis
N Keyter, P P Oosthuizen, R A Emsley, H J Turner
66. Self-reort vs urinary drug screening in Schizophrenia: A pilot study
L Koen, D J H Niehaus, J E Muller, C Seller, N Keyter
67. The effect of aggression on the use of Psychotropics in Schizophrenia: A naturalistic study
H Lategan, L Koen, D J H Niehaus
68. Factor analysis of obsessive-compulsive spectrum disorders in patients with obsessive-compulsive Disorder: Clinical and genetic correlates
C Lochner, D J H Niehaus, S M J Hemmings, C J Kinnear, V A Corfield, J C Moolman-Smook, D J Stein
69. Experiences in obsessive-compulsive disorder and Trichotillomania: Role of childhood trauma
C Lochner, S Seedat, P D Carey, D J Stein
70. Delusional systems in Xhosa Schizophrenia Sibpairs
J E Muller, D J H Niehaus, L Koen, C Seller, N Keyter, C Laurent, R A Emsley
71. OCD Heteogeneity reflected by lack of Genealogically determined founder effect
D J H Niehaus, L Endeman, I Bosman, S Hemmings, C Lochner, L Koen, H Moolman-Smook, V A Corfield, D J Stein
72. The efficacy and tolerability of low-dose vs standard dose Haloperidol in first episode Psychosis. A randomised, double-blind study
P P Oosthuizen, R A Emsley, H J Turner, N Keyter
73. Treatment with low-dose Haloperidol does not protect against Tardive Dyskinesia
P P Oosthuizen, R A Emsley, H J Turner, N Keyter
74. Do healthcare funders discriminate against members on the grounds of mental illness?
O Scholtz, P P Oosthuizen, C Hugo, B Richards
75. Treatment strategies in patients with Clozapine resistant Schizophrenia at Stikland Hospital: A critical evaluation of one option
A Schulte, D J H Niehaus, L Koen, J E Muller, P P Oosthuizen, R A Emsley
76. Early coadministration of Clonazepam with Paroxetine for generalised Social Anxiety Disorder
S Seedat, M B Stein
77. Trauma exposure and post-traumatic stress symptoms in adolescents: A schools' survey in Cape Town (South Africa) and Nairobi (Kenya)
S Seedat, C Nyamap, F Njenga, B Vythilingum, D J Stein
78. The QTC effects of Thioridazine when used as a second line Antipsychotic (at Stikland Hospital)
C Seller, P P Oosthuizen
79. Brain imaging and substance related disorders
D J Stein
80. Gender differences in trauma exposure & post traumatic stress disorder in a clinic sample
S Suliman, S Seedat, F Gxama, J Walker, W Rossouw
81. Assessing the prevalence of anxiety and depressive symptoms among clinicians at Tygerberg Academic Hospital and controls
H Van der Bijl, P P Oosthuizen
82. Pharmacological challenge with a Serotonin ID agonist in alcohol dependence
B Vythilingum, C Wessels, S Maritz, W P Pienaar, D J Stein
83. The treatment of ADHD in adults
W Verbeec