Mean [95% CI] changes in plasma Lp(a) from baseline by diet in all participants (Fig. 1a) and in blacks and whites (Fig. 1b) are shown.

<p>P-values for differences to baseline (Fig. 1a) and between races (Fig. 1b) are displayed. All interventions increased Lp(a). Between races, study diets increased Lp(a) in blacks more than in whites with significant differences after the Prot diet.</p

Participant Characteristics at baseline¹.

1<p>HOMA, homeostasis model assessment; LDL-C, LDL cholesterol; HDL-C, HDL cholesterol; Apo, apolipoprotein. P values were derived from Student's t test comparing the different races. Values are unadjusted means ± SD.</p><p>Participant Characteristics at baseline^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0114859#nt101" target="_blank">1</a>}.</p

Lp(a) concentration (mg/dl) with diet by ethnicity: Changes from baseline and differences between diets reported as mean [95% CI].

<p>Lp(a) concentration (mg/dl) with diet by ethnicity: Changes from baseline and differences between diets reported as mean [95% CI].</p

Baseline Intake and Nutrient Targets of Omni Heart Diets.

<p>Baseline Intake and Nutrient Targets of Omni Heart Diets.</p

Baseline characteristics of the 366 controls in the CARE populations by quartiles of PTX3.

<p>IQR  =  interquartile range. MDRD-GFR  =  Modification of Diet in Renal Disease-Glomerular Filtration Rate.</p

Lack of association between PTX3 and short pentraxin.

<p>Spearman correlations revealed no association between plasma levels of the long pentraxin PTX3 and the short pentraxin CRP (A). Plasma PTX3 levels positively correlated with plasma SAA levels (B), and plasma CRP and SAA levels correlated strongly with each other (C). After exclusion of participants with high CRP levels (>10 mg/L), PTX3 showed no significant correlations with CRP and SAA (D and E), whereas CRP and SAA correlated positively with each other (F).</p

PTX3 levels associate adversely with metabolic syndrome components.

<p>Mean values of selected characteristics (BMI, waist circumference, triglyceride, and HDL cholesterol) by quartile of PTX3. Mean values were estimated from linear regression models, adjusted for age.</p

PTX3 associates negatively with obesity and metabolic syndrome in non-diabetic subject.

<p>PTX3 associates negatively with obesity but positively with diabetes mellitus (A). Mean plasma PTX3 levels among 779 individuals, comparing non-obese (BMI <30) and obese individuals (BMI ≥30) (left), or non-diabetic and diabetic control individuals (right). Mean values were estimated from linear regression models, adjusted for age, sex, smoking status, triglycerides, HDL cholesterol, and hypertension. Models for diabetes also adjusted for BMI. PTX3 negatively associates with obesity among non-diabetic individuals (B). Mean values of plasma PTX3 levels by BMI category in non-diabetic (left) and diabetic individuals (right) estimated from linear regression models. Mean values adjusted for age, sex, smoking status, triglycerides, HDL cholesterol, and hypertension. PTX3 associates negatively with the number of metabolic syndrome components (C). Mean values of plasma PTX3 levels according to presence of 0, 1, 2, 3, and 4 or more components of metabolic syndrome in all individuals (left) and non-diabetic individuals (right). Mean values estimated from linear regression models, adjusted for age, sex, and smoking status.</p

Online Supplementary Material: DNA methylation near CPT1A and changes in triglyceride-rich lipoproteins in response to weight-loss diet interventions

Online supplementary material</p

Study design.

<p>A flow chart outlining the patients and SNPs investigated in the 2 stages of the study.</p