Results of univariate and multivariate models of survival analysis, predicting the onset of panic attacks with standardized YSR scores and adjusted for gender and SES.

*<p>p<.05 **p<.01 ***p<.0001.</p><p>YSR = Youth Self-Report; SES = Socio-economic status; CI = confidence interval;</p>1<p>part of the Externalizing scale; ² part of the Internalizing scale; ^a the eight subscales were entered into one multivariate model, and the subscales <i>Externalizing</i> and <i>Internalizing</i> were entered into a separate multivariate model.</p

Multinomial logistic regression analysis of educational attainment at age 19 and externalizing, internalizing and attention problems at age 11.

<p>*p<0.05; **p<0.01; ***p<0.001.</p><p>Model 1: Crude model | Model 2: Adjusted for age, gender, IQ, parental educational level and physical health |Model 3: Adjusted for age, gender, IQ, parental educational level, physical health, internalizing or/and externalizing or/and attention problems.</p

Univariate regression analyses with CBCL scores at T2 as dependent variable (standardised regression coefficients with standard errors).

<p>CBCL, Child Behaviour Checklist; MHS, Mental Health Services; IQ, Intelligence Quotient; EXT, Externalising disorder; INT, internalising disorder; (t) teacher and (p) parent rating.</p>*<p>p-value<0.05;</p>**<p>p-value<0.01;</p>***<p>p-value<0.001.</p

Descriptive information of the dependent, independent and confounding variables.

<p>Chi-square tests are performed for categorical variables and one-way ANOVA analyses for continuous variables.</p

MHS use and CBCL scores across the three measurement waves.

<p>In this figure, mean CBCL total problem scores are displayed of propensity matched TRAILS participants that did or did not use MHS during a certain time period. Legend: Blue line denotes TRAILS participants with no MHS at any time (N = 146). Red line denotes TRAILS participants with MHS between T1 and T2 (N = 114). Green line denotes TRAILS participants with MHS between T2 and T3 (N = 21). Purple line denotes TRAILS participants with continuous MHS use (N = 53). CBCL: Child Behaviour Checklist, total problem score. MHS: Mental health services.</p

Multinomial logistic regression analysis of educational attainment at age 19 and difference scores of externalizing, internalizing and attention problems between age 11 and 16.

<p>*p<0.05; **p<0.01; ***p<0.001.</p><p>Model 1: Adjusted for baseline mental health problems | Model 2: Adjusted for age, gender, IQ, parental educational level, physical health, and baseline mental health problems | Model 3: Adjusted for age, gender, IQ, parental educational level, physical health, internalizing or/and externalizing or/and attention problems and baseline mental health problems.</p

The Dutch educational system.

<p>The Dutch educational system.</p

A and B. Uncorrected and propensity adjusted mean CBCL-scores of TRAILS participants with and without MHS use.

<p>In <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0044704#pone-0044704-g001" target="_blank">figure 1A</a>, mean total problem scores (CBCL) are displayed of TRAILS participants with and without MHS use at baseline (T1) and follow up (T2). In <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0044704#pone-0044704-g001" target="_blank">figure 1B</a>, mean total problem scores (CBCL) are displayed of propensity matched TRAILS participants with and without MHS use. The participants who did not use MHS had, at baseline, the same propensity (i.e. likelihood) to receive MHS as the participants who actually used MHS. Legend A: Red square denotes TRAILS participants with MHS use (N = 188). Blue square denotes TRAILS participants without MHS use (N = 1692). CBCL: Child Behaviour Checklist, total problem score. MHS: Mental health services. Legend B: Red square denotes TRAILS participants with MHS use (N = 167). Blue square denotes propensity score matched TRAILS participants without MHS use (N = 167). CBCL: Child Behaviour Checklist, total problem score. MHS: Mental health services.</p

CBCL scores at T2 predicted by MHS use between T1 and T2, adjusted for baseline severity of symptoms (model 1); baseline severity and markers of adolescents vulnerability and resilience (model 2); and baseline severity, markers of adolescent vulnerability and resilience, and stressful life events (model 3).

<p>Standardised regression coefficients (ß) and standard errors (SE) are presented.</p><p>CBCL, Child Behaviour Checklist; MHS, Mental Health Services; IQ, Intelligence Quotient; (t) teacher and (p) parent rating. Adjusted R² model 1: 0.51; model 2: 0.52; model 3: 0.52.</p>*<p>p-value<0.05;</p>**<p>p-value<0.01;</p>***<p>p-value<0.001.</p

Determinants of use of care, adjusted for gender and wave, and additionally for all shown factors: odds ratios (OR), and 95% confidence intervals (CI) from multilevel logistic regression.

<p>Bold = p<. 05.</p>#<p>measurement of need at preceding wave was used as predictor for use in next wave, e.g. CBCL at T1 was used as predictor of use at T2, etc.</p