Fast Stochastic Cooling of Heavy Ions at the ESR Storage Ring

Since the completion of the installation of pick-up and kicker tanks in the ESR, stochastic cooling in all phase space dimensions has been demonstrated with rather short cooling times. New RF components were added. The system is now ready for experiments with secondary beams. The momentum sensitivity of the pick-up electrodes was measured. The ability of the Palmer cooling system to cool beams with a maximum momentum spread of ± 0.7 % was demonstrated. After injecting an uncooled primary argon beam from the SIS synchrotron, e-folding cooling times of 0.86 s in the longitudinal phase plane and 1.6 s in the horizontal plane were measured with 5×106 injected particles. These values are close to theoretical expectations. In a first experiment with uranium, the shortest cooling times have been below 0.5 s in both the longitudinal and vertical phase planes. The system cools the complete injected beam without beam loss. An experiment with beam accumulation following stochastic precooling was performed successfully. The resulting equilibrium phase space densities are high enough to be followed by fast electron cooling of the stack

Stochastic Cooling at the ESR

Stochastic precooling at the ESR storage ring of GSI will be used mainly for experiments with stored radioactive fragment beams. They arrive from the fragment separator with momentum spreads and emittances for which electron cooling is too slow. The installation of components at the ESR is now complete and first commissioning experiments have been performed. Both longitudinal and transverse stochastic cooling have been demonstrated. The paper gives a short account of the system architecture, and of the response of quarter-wave plates and superelectrodes at intermediate energies. The preparation of fragment beams suitable for subsequent electron cooling is discussed for the case that a mixture of different ion species is present in the cooler ring. Results of commissioning and future prospects are presented

Fabrication Technologies of the Sintered Materials Including Materials for Medical and Dental Application

This chapter of the book presents the basis of classical powder metallurgy technologies and discusses powder fabrication, preparation, preliminary moulding, sintering and finish treatment operations. A general description of the materials and products manufactured with the classical powder metallurgy methods is presented. New variants are characterised along with special and hybrid technologies finding their applications in powder metallurgy. Special attention was drawn to microporous titanium and to TiAl6V4 alloy fabricated using hybrid rapid manufacturing technologies with selective laser sintering/selective laser melting (SLS/SLM) used for innovative implant scaffolds in medicine and regenerative dentistry. Laser deposition, thermal spraying and detonation spraying of powders are also discussed as special methods in which powders of metals and other materials are used as raw materials

Microporous Titanium-Based Materials Coated by Biocompatible Thin Films

This chapter presents the outcomes of numerous own works concerning constructional solutions and fabrication technologies of a new generation of custom, original, hybrid, microporous high-strength engineering and biological materials with microporous rigid titanium and Ti6Al4V alloy skeletons manufactured by Selective Laser Sintering (SLS), whose pores are filled with living cells. The so constructed and fabricated implants, in the connection zone with bone stumps, contain a porous zone, with surface treatment inside pores, enabling the living tissues to grow into. As the adhesion and growth of living cells are dependent on the type and characteristic of the substrate it is necessary to create the most advantageous proliferation conditions of living cells inside the pores of a microporous skeleton made of titanium and Ti6Al4V alloy. In order to improve the proliferation conditions of cells ensured by a fully compatible substrate, internal coatings with TiO2, Al2O3 oxides and Ca10(PO4)6(OH)2 hydroxyapatite of the surface of pores of a microporous skeleton made of titanium and Ti6Al4V alloy with SLS was used. Two technologies have been chosen for the deposition of thin coatings onto the internal surfaces of pores: Atomic Layer Deposition (ALD) and the sol-gel of deep coating from the liquid phase

Porous Selective Laser Melted Ti and Ti6Al4V Materials for Medical Applications

This chapter characterises scaffolds manufactured in line with the make-to-order concept according to individual needs of each patient. The clinical data acquired from a patient during computer tomography, nuclear magnetic resonance or using traditional plaster casts is converted by a computer into a virtual solid model of a patient’s loss. The model, through the multiplication of a unit cell, is converted into a porous model on the basis of which an actual object is manufactured with the method of selective laser melting (SLM) from Ti/Ti6Al4V powders. The created scaffold is characterised by good mechanical properties, which is confirmed by the results of the performed tensile and compressive strength tests. The material is additionally subjected to surface treatment consisting of the deposition of atomic layers of titanium dioxide with nanometric thickness

Difference in expression between AQP1 and AQP5 in porcine endometrium and myometrium in response to steroid hormones, oxytocin, arachidonic acid, forskolin and cAMP during the mid-luteal phase of the estrous cycle and luteolysis

BACKGROUND: Recently, we demonstrated in vitro that AQP1 and AQP5 in the porcine uterus are regulated by steroid hormones (P4, E2), arachidonic acid (AA), forskolin (FSK) and cAMP during the estrous cycle. However, the potential of the porcine separated uterine tissues, the endometrium and myometrium, to express these AQPs remains unknown. Thus, in this study, the responses of AQP1 and AQP5 to P4, E2 oxytocin (OT), AA, FSK and cAMP in the porcine endometrium and myometrium were examined during the mid-luteal phase of the estrous cycle and luteolysis.METHODS: Real-time PCR and western blot analysis.RESULTS: Progesterone up-regulated the expression of AQP1/AQP5 mRNAs and proteins in the endometrium and myometrium, especially during luteolysis. Similarly, E2 also stimulated the expression of both AQPs, but only in the endometrium. AA led to the upregulation of AQP1/AQP5 in the endometrium during luteolysis. In turn, OT increased the expression of AQP1/AQP5 mRNAs and proteins in the myometrium during mid-luteal phase. Moreover, a stimulatory effect of forskolin and cAMP on the expression of AQP1/AQP5 mRNAs and proteins in the endometrium and myometrium dominated during luteolysis, but during the mid-luteal phase their influence on the expression of these AQPs was differentiated depending on the type of tissue and the incubation duration.CONCLUSIONS: These results seem to indicate that uterine tissues; endometrium and myometrium, exhibit their own AQP expression profiles in response to examined factors. Moreover, the responses of AQP1/AQP5 at mRNA and protein levels to the studied factors in the endometrium and myometrium are more pronounced during luteolysis. This suggests that the above effects of the studied factors are connected with morphological and physiological changes taking place in the pig uterus during the estrous cycle.</p

Composite Materials Infiltrated by Aluminium Alloys Based on Porous Skeletons from Alumina, Mullite and Titanium Produced by Powder Metallurgy Techniques

The infiltration technology with reinforcement in the form of porous skeletons fabricated with powder metallurgy methods has been presented in relation to the general characteristics of metal alloy matrix composite materials. The results of our own investigations are presented pertaining to four alternative technologies of fabrication of porous, sintered skeletons, and their structure and their key technological properties are presented. Porous skeletons made of Al2O3 aluminium are sintered reactively using blowing agents or are manufactured by ceramic injection moulding (CIM) from powder. Porous skeletons made of 3Al2O3⋅2SiO2 mullite are achieved by sintering a mixture of halloysite nanotubes together with agents forming an open structure of pores. Titanium porous skeletons are achieved by selective laser sintering (SLS). The structure and properties of composite materials with an aluminium alloy matrix—mainly EN AC-AlSi12 and also EN AC-AlSi7Mg0.3 alloys—reinforced with the so manufactured skeletons are also described. A unique structure of the achieved composite materials, together with good mechanical properties and abrasive wear resistance at low density, ensured by an aluminium alloy matrix, are indicating broad application possibilities of such composites