Evolutionary history of the UCP gene family: gene duplication and selection

<p>Abstract</p> <p>Background</p> <p>The uncoupling protein (UCP) genes belong to the superfamily of electron transport carriers of the mitochondrial inner membrane. Members of the uncoupling protein family are involved in thermogenesis and determining the functional evolution of UCP genes is important to understand the evolution of thermo-regulation in vertebrates.</p> <p>Results</p> <p>Sequence similarity searches of genome and scaffold data identified homologues of UCP in eutherians, teleosts and the first squamates uncoupling proteins. Phylogenetic analysis was used to characterize the family evolutionary history by identifying two duplications early in vertebrate evolution and two losses in the avian lineage (excluding duplications within a species, excluding the losses due to incompletely sequenced taxa and excluding the losses and duplications inferred through mismatch of species and gene trees). Estimates of synonymous and nonsynonymous substitution rates (dN/dS) and more complex branch and site models suggest that the duplication events were not associated with positive Darwinian selection and that the UCP is constrained by strong purifying selection except for a single site which has undergone positive Darwinian selection, demonstrating that the UCP gene family must be highly conserved.</p> <p>Conclusion</p> <p>We present a phylogeny describing the evolutionary history of the UCP gene family and show that the genes have evolved through duplications followed by purifying selection except for a single site in the mitochondrial matrix between the 5^thand 6^thα-helices which has undergone positive selection.</p

Brood patch temperature during provocation of incubating common eiders in Ny-Ålesund, Svalbard

In this short note we describe the behaviour and body changes of three incubating female common eiders (Somateria mollissima) during provocation made by humans approaching the nest. The study site was near the settlement of Ny-Ålesund, Svalbard. Temperture transmitters were implanted subcutaneously at the brood patch and data recorded using a VHF receiver. We found that the female experiment exhibited a passive defence response (“freezing”), accompanied by a significant drop in brood patch temperature (0.6 °C) during provocation; this temperature drop lasted for 5 minutes. These accord with other studies of the physiological changes which the passive defence response in birds and other animals

Increased ROS Production: A Component of the Longevity Equation in the Male Mygalomorph, Brachypelma albopilosa

The diversity of longevities encountered in wildlife is one of the most intriguing problems in biology. Evolutionary biologists have proposed different theories to explain how longevity variability may be driven by bad genes expression in late life or by gene pleiotropic effects. This reflexion has stimulated, in the last ten years, an active research on the proximal mechanisms that can shape lifespan. Reactive oxygen species (ROS), i.e., the by-products of oxidative metabolism, have emerged as the main proximate cause of ageing. Because ROS are mainly produced by the mitochondria, their production is linked to metabolic rate, and this may explain the differences in longevity between large and small species. However, their implication in the sex difference in longevity within a species has never been tested, despite the fact that these differences are widespread in the animal kingdom.Mitochondrial superoxide production of hemolymph immune cells and antioxidant and oxidative damages plasma levels were measured in adult male and female B. albopilosa at different ages. We found that female spiders are producing less mitochondrial superoxide, are better protected against oxidative attack and are then suffering less oxidative damages than males at adulthood.In tarantulas, once reaching sexual maturity, males have a life expectancy reduced to 1 to 2 years, while females can still live for 20 years, in spite of the fact that females continue to grow and moult. This study evidences an increased exposure of males to oxidative stress due to an increase in mitochondrial superoxide production and a decrease in hemolymph antioxidant defences. Such a phenomenon is likely to be part of the explanation for the sharp reduction of longevity accompanying male tarantula maturity. This opens several fundamental research roads in the future to better understand how reproduction and longevity are linked in an original ageing model

Does IGF-1 shape life-history trade-offs? : Opposite associations of IGF-1 with telomere length and body size in a free-living bird

Funding. PB, FC and AS were supported by a Carnegie Research Incentive Grant (RIG007773). BM was supported by a Godfrey Hewitt Mobility Award from the European Society for Evolutionary Biology. ÁZL was supported by a grant from the National Research and Development Office (K139021).Peer reviewedPublisher PD

Does IGF-1 Shape Life-History Trade-Offs? Opposite Associations of IGF-1 With Telomere Length and Body Size in a Free-Living Bird

Hormonal pathways have been proposed to be key at modulating how fast individuals grow and reproduce and how long they live (i.e., life history trajectory). Research in model species living under controlled environment is suggesting that insulin-like growth factor 1 (IGF-1), which is an evolutionarily conserved polypeptide hormone, has an important role in modulating animal life histories. Much remains, however, to be done to test the role played by IGF-1 in shaping the phenotype and life history of animals in the wild. Using a wild long-lived bird, the Alpine swift (Tachymarptis melba), we show that adults with higher levels of IGF-1 had longer wings and shorter telomeres. Hence, telomeres being a proxy of lifespan in this species, our results support a potential role of IGF-1 at shaping the life-history of wild birds and suggest that IGF-1 may influence the growth-lifespan trade-off

Foster rather than biological parental telomere length predicts offspring survival and telomere length in king penguins

Because telomere length and dynamics relate to individual growth, reproductive investment and survival, telomeres have emerged as possible markers of individual quality. Here, we tested the hypothesis that, in species with parental care, parental telomere length can be a marker of parental quality that predicts offspring phenotype and survival. In king penguins (Aptenodytes patagonicus), we experimentally swapped the single egg of 66 breeding pairs just after egg laying to disentangle the contribution of prelaying parental quality (e.g., genetics, investment in the egg) and/or postlaying parental quality (e.g., incubation, postnatal feeding rate) on offspring growth, telomere length and survival. Parental quality was estimated through the joint effects of biological and foster parent telomere length on offspring traits, both soon after hatching (day 10) and at the end of the prewinter growth period (day 105). We expected that offspring traits would be mostly related to the telomere lengths (i.e., quality) of biological parents at day 10 and to the telomere lengths of foster parents at day 105. Results show that chick survival up to 10 days was negatively related to biological fathers' telomere length, whereas survival up to 105 days was positively related to foster fathers' telomere lengths. Chick growth was not related to either biological or foster parents' telomere length. Chick telomere length was positively related to foster mothers' telomere length at both 10 and 105 days. Overall, our study shows that, in a species with biparental care, parents' telomere length is foremost a proxy of postlaying parental care quality, supporting the "telomere - parental quality hypothesis.

Solitary living species age too, and fast!

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Quick guide to evolutionary medicine in neuroimmunomodulation: Why “evolved for the benefit of the species” is not a valid argument

International audienceEvolutionary medicine builds on evolutionary biology and explains why natural selection has left us vulnerable to disease. Unfortunately, several misunderstandings exist in the medical literature about the levels and mechanisms of evolution. Reasons for these problems start from the lack of teaching evolutionary biology in medical schools. A common mistake is to assume that “traits must benefit the species, as otherwise the species would have gone extinct in the past”, confusing evolutionary history (phylogeny) with evolutionary function (fitness). Here we summarize some basic aspects of evolutionary medicine by pointing out: 1. Evolution has no aim. 2. For adaptive evolution to occur, a trait does not have to be beneficial to its carrier throughout its entire life. 3. Not every single individual carrying an adaptive trait needs to have higher than average fitness. 4. Traits do not evolve for the benefit of the species. Using examples from the field of neuroimmunomodulation like sickness behaviour (nervous system), testosterone (hormones), and cytokines (immunity), we show how misconceptions arise from not differentiating between the explanatory categories of phylogeny (evolutionary history) and evolutionary function (fitness)

Seasonal variation in telomere dynamics in African striped mice

International audienceTelomere shortening has been used as an indicator of aging and is believed to accelerate under harsh environmental conditions. This can be attributed to the fact that telomere shortening has often been regarded as non-reversible and negatively impacting fitness. However, studies of laboratory mice indicate that they may be able to repair telomere loss to recover from environmental harshness, as indicated by recent studies in hibernating rodents. We studied seasonal variation in telomere dynamics in African striped mice (Rhabdomys pumilio) living in a highly seasonal environment. In our annual species, individuals born in the moist spring (high food availability) need to survive the harsh dry summer (low food availability) to be able to reproduce in the following spring. We studied the effect of the harsh dry vs. the benign moist season on telomere dynamics. We also tested whether telomere length and changes in telomere length were associated with the probability that individuals disappeared form the population during the dry season. Male but not female stripped mice showed age-related telomere erosion. Telomeres were longer at the beginning of the dry season compared to the rest of the year. Telomeres increased significantly in length during the moist season. Neither telomere length at the onset of the dry season nor telomere loss over the dry season predicted whether or not individuals disappeared. In conclusion, our data suggest that seasonal attrition and restoring of telomeres also occurs in non-hibernating wild rodents living in hot food restricted environment