Areas under ROC curves analysis of DTI and MRSI derived measures in different groups of MS patients.

<p>Statistical significance (*p<0.05; **p<0.01; ***p<0.001) when comparing areas under ROC curves (AUC) of the following MR metrics: MD: mean diffusivity, λr: radial diffusivity, NAA: N-acetylaspartate, Cr: creatine, RR: relapsing remitting; SP: secondary progressive; PP: primary progressive.</p

ROC curves of the mean diffusion (MD), axial (λa) and radial (λr) diffusivities, NAA/Cho and NAA/Cr ratios in RR (A), SP (B), PP (C) and all-MS patient groups (D).

<p>ROC curves of the mean diffusion (MD), axial (λa) and radial (λr) diffusivities, NAA/Cho and NAA/Cr ratios in RR (A), SP (B), PP (C) and all-MS patient groups (D).</p

Correlations between radial diffusivity (λr) and NAA/Cr ratio with the ROI T2-LL in RR, PP and all-MS patient groups. (NS = Not significant).

<p>Correlations between radial diffusivity (λr) and NAA/Cr ratio with the ROI T2-LL in RR, PP and all-MS patient groups. (NS = Not significant).</p

Demographics and group characteristics.

<p>Values are expressed as mean (Standard deviation).</p><p>RR: relapsing remitting; SP: secondary progressive; PP: primary progressive; EDSS: expanded disability status scale; ROI T2-LL: T2-lesion load corresponding to the lesion volume measured within the region of interest (ROI); Brain T2-LL: T2-lesion load corresponding to the lesion volume measured in the whole brain.</p

Correlation rates (r) between diffusion and metabolic measures and the ROI T2-LL in different groups of MS patients.

<p>Correlation significance (*p<0.05; **p<0.01; ***p<0.001).</p><p>ROI T2-LL: T2-lesion load corresponding to the lesion volume within the region of interest, MD: mean diffusion, FA: fraction of anisotropy, λa: axial diffusivity, λr: radial diffusivity, NAA: N-acetylaspartate, Cr: creatine, RR: relapsing remitting; SP: secondary progressive; PP: primary progressive.</p

Diffusion and metabolic measures in MS patients and control subjects groups.

<p>Values (Mean ± SD) of mean diffusion (MD), fraction of anisotropy (FA), axial (λa) and radial (λr) diffusivities, N-acetylaspartate (NAA), choline (Cho) and creatine (Cr) (*p<0.05; **p<0.01; ***p<0.001 when compared to controls). RR: relapsing remitting; SP: secondary progressive; PP: primary progressive.</p