4 research outputs found

    Shades of green: untying the knots of green photoperception

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    The development of economical LED technology has enabled the application of different light qualities and quantities to control plant growth. Although we have a comprehensive understanding of plants’ perception of red and blue light, the lack of a dedicated green light sensor has frustrated our utilisation of intermediate wavelengths, with many contradictory reports in the literature. We discuss the contribution of red and blue photoreceptors to green light perception and highlight how green light can be used to improve crop quality. Importantly, our meta-analysis demonstrates that green light perception should instead be considered as a combination of distinct ‘green-’ and ‘yellow-’light induced responses. This distinction will enable clearer interpretation of plants’ behaviour in response to green light as we seek to optimise plant growth and nutritional quality in horticultural contexts

    Oxidized/deamidated-ceruloplasmin dysregulates choroid plexus epithelial cells functionality and barrier properties via RGD-recognizing integrin binding.

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    Abstract Choroid plexus epithelial cells (CPEpiCs) determine the composition of cerebrospinal fluid (CSF) and constitute the blood-CSF barrier (BCSFB), functions that are altered in neurodegenerative diseases. In Parkinson's disease (PD) the pathological environment oxidizes and deamidates the ceruloplasmin, a CSF-resident ferroxidase, which undergoes a gain of RGD-recognizing integrin binding property, that may result in signal transduction. We investigated the effects that oxidized/deamidated ceruloplasmin (Cp-ox/de) may exert on CPEpiCs functions. Through RGD-recognizing integrins binding, Cp-ox/de mediates CPEpiCs adhesion and intracellular signaling, resulting in cell proliferation inhibition and alteration of the secretome profile in terms of proteins related to cell-extracellular matrix interaction. Oxidative conditions, comparable to those found in the CSF of PD patients, induced CPEpiCs barrier leakage, allowing Cp-ox/de to cross it, transducing integrins-mediated signal that further worsens BCSFB integrity. This mechanism might contribute to PD pathological processes altering CSF composition and aggravating the already compromised BCSFB function

    Nonni e nipoti. Storia degli industriali italiani

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    - Tessili. Un grano di follia dietro le barbe #7- Cantieri navali. Il futuro arriva in barca #45- Alimentari. Il re nelle ville del Chianti #85- Farmaceutici. Le pillole d'oro #125- Chimici. Dal concime la grande avventura #165- Industria elettrica. L'industria dei contatori #205- Automobili. L'automobile parla piemontese #245- Meccanica pesante. Il grande cliente è lo Stato #365- Siderurgia. I padroni delle ferriere #405- Industrie complementari. Le gomme, il cemento, le strade #445- Indice generale #48
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