679 research outputs found
Volatile compared with total intravenous anaesthesia in patients undergoing high-risk cardiac surgery: a randomized multicentre study
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Dynamic Vortex Phases and Pinning in Superconductors with Twin Boundaries
We investigate the pinning and driven dynamics of vortices interacting with
twin boundaries using large scale molecular dynamics simulations on samples
with near one million pinning sites. For low applied driving forces, the vortex
lattice orients itself parallel to the twin boundary and we observe the
creation of a flux gradient and vortex free region near the edges of the twin
boundary. For increasing drive, we find evidence for several distinct dynamical
flow phases which we characterize by the density of defects in the vortex
lattice, the microscopic vortex flow patterns, and orientation of the vortex
lattice. We show that these different dynamical phases can be directly related
to microscopically measurable voltage - current V(I) curves and voltage noise.
By conducting a series of simulations for various twin boundary parameters we
derive several vortex dynamic phase diagrams.Comment: 5 figures, to appear in Phys. Rev.
Thimet oligopeptidase (EC 3.4.24.15) key functions suggested by knockout mice phenotype characterization
Thimet oligopeptidase (THOP1) is thought to be involved in neuropeptide metabolism, antigen presentation, neurodegeneration, and cancer. Herein, the generation of THOP1 C57BL/6 knockout mice (THOP1(-/-)) is described showing that they are viable, have estrus cycle, fertility, and a number of puppies per litter similar to C57BL/6 wild type mice (WT). In specific brain regions, THOP1(-/-) exhibit altered mRNA expression of proteasome beta5, serotonin 5HT2a receptor and dopamine D2 receptor, but not of neurolysin (NLN). Peptidomic analysis identifies differences in intracellular peptide ratios between THOP1(-/-) and WT mice, which may affect normal cellular functioning. In an experimental model of multiple sclerosis THOP1(-/-) mice present worse clinical behavior scores compared to WT mice, corroborating its possible involvement in neurodegenerative diseases. THOP1(-/-) mice also exhibit better survival and improved behavior in a sepsis model, but also a greater peripheral pain sensitivity measured in the hot plate test after bradykinin administration in the paw. THOP1(-/-) mice show depressive-like behavior, as well as attention and memory retention deficits. Altogether, these results reveal a role of THOP1 on specific behaviors, immune-stimulated neurodegeneration, and infection-induced inflammation
Differential Cross Section of DP-Elastic Scattering at Intermediate Energies
The deuteron-proton elastic scattering is studied in the multiple scattering
expansion formalism. The contributions of the one-nucleon-exchange, single- and
double scattering are taken into account. The Love and Franey parameterization
of the nucleon-nucleon -matrix is used, that gives an opportunity to include
the off-energy-shell effects into calculations. Differential cross sections are
considered at four energies, MeV. The obtained
results are compared with the experimental data
Determination of left atrial volume in healthy dogs and dogs with myxomatous mitral valve disease
Intrafloral phenology of Trifolium polymorphum Poir. (Leguminosae) aerial flowers and reproductive implications
Development and bacteriological, chemical and sensory characterization of fishburgers made of Tilapia minced meat and surimi
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