¿La ‘soberanía de la tierra’ como alternativa? Hacia un contracercamiento de los pueblos

1. La soberanía de la tierra se refiere al derecho que tienen los pueblos trabajadores al acceso efectivo a la tierra, al uso de ella y a su control, así como a los beneficios de su uso y ocupación, entendiendo la tierra como un recurso, como territorio y como paisaje. 2. La soberanía de la tierra es tanto un llamado a la acción en contra de los renovados esfuerzos corporativos y (trans)nacionales para cercar el patrimonio común como la afirmación de la necesidad de un cercamiento popular de la tierra, que apoye a los pueblos trabajadores y su derecho humano a ejercer control sobre la tierra. ..

A ‘Land Sovereignty’ Alternative? Towards a Peoples’ Counter-Enclosure

1. Land sovereignty is the right of working peoples to have effective access to, use of, and control over land and the benefits of its use and occupation, where land is understood as resource, territory, and landscape. 2. Land sovereignty is both a call to action against a renewed corporate and (trans)national global push to enclose the commons and an assertion of the need for a people’s enclosure of the land; supporting working peoples and their human right to control over land. ..

Tendencias políticas en disputa para la gobernanza global del acaparamiento de tierras

La expansión de los ‘cultivos y materias primas flexibles’ en el marco de una transición paulatina en el régimen alimentario global, junto a la emergencia de los países BRICS y MICS (de Renta Media) y el revalorizado papel de los estados nación, conforman un contexto crítico para el acaparamiento de tierras. Estas transformaciones globales que determinan, y son a su vez determinadas por, el actual acaparamiento global de tierras, han resultado en varias interpretaciones en disputa alrededor de su significado, complejizando aún más el ya de por si complejo terreno de la gobernanza. Estamos siendo testigos de una disputa política tripartita sobre el control del carácter, ritmo, parámetros y trayectoria discursiva, así como de los instrumentos sobre, y la práctica de, la gobernanza global del acaparamiento de tierras, como en el caso de las Directrices Voluntarias del Comité de Seguridad Alimentaria Mundial de la ONU. Esta contienda gira alrededor de las siguientes tres tendencias: ‘regular para facilitar’, ‘regular para mitigar impactos negativos y maximizar oportunidades’, y ‘regular para detener y revertir’ el acaparamiento de tierras. Las trayectorias futuras del acaparamiento de tierras serán determinadas en buena medida por el balance entre fuerzas sociales y estatales en cada una y entre las tres tendencias políticas. Este artículo plantea un análisis preliminar a partir del mapeo de áreas de indagación sub-exploradas y ofrece más una serie de modos de cuestionamiento inicial, que argumentos firmes basados en material empírico sólido y completo

Climate change and land: Insights from Myanmar

Climate change and land are linked – politically. Climate change politics intersects with the global land rush in extensive and complex ways, the impacts of which affect villagers profoundly. These interconnections occur in direct and indirect ways and are often subtle, but that does not make them less important; it only makes the challenge of governing such dynamics in the interests of marginalized working poor people even more difficult. In this paper, we focus our analysis on indirect and subtle interconnections. Examining empirical cases in Northern Shan State in Myanmar, we conclude that these interconnections occur in at least three broad ways, in which climat

El Acaparamiento de Tierras en América Latina y el Caribe Visto Desde una Perspectiva Internacional más Amplia

Introducción y mensajes claves Este documento se basa en la investigación empírica que fue encomendada por la Organización de las Naciones Unidas para la Alimentación y la Agricultura (FAO) sobre las condiciones y tendencias del ―acaparamiento de tierras‖ en 17 países de América Latina y el Caribe (véase el Anexo para una lista completa de los estudios, así como el documento síntesis correspondiente; FAO, 2011). Los 17 estudios se concluyeron a mediados de 2011. El marco analítico común de los estudios es amplio, pero a la vez focalizado. Por un lado es amplio porque analiza los procesos generales de las tierras rurales y la concentración de capital en el contexto de la globalización neoliberal. Por el otro, es focalizado porque analiza el fenómeno del ―acaparamiento de tierras‖ basándose estrictamente en tres dimensiones específicas, a saber: i) el gran alcance de las adquisiciones de tierra a gran escala; ii) la participación de los gobiernos extranjeros en estos tratos sobre tierras; y iii) el impacto negativo de dichas inversiones recientes en tierras sobre la seguridad alimentaria del país receptor. Es en gran medida debido a este tipo de marco analítico que la mayoría de los estudios pudieron desentrañar y recopilar gran cantidad de material empírico relacionado con la dinámica de las tierras en la región; sin embargo, dado que el enfoque de su análisis y conclusiones se basó en la definición y la dimensión angostas del acaparamiento de tierras, la conclusión obtenida fue que el ―acaparamiento de tierras‖ se da únicamente en dos países de la región: Argentina y Brasil. ..

Climate change and land: insights from Myanmar

Climate change and land are linked – politically. Climate change politics intersects with the global land rush in extensive and complex ways, the impacts of which affect villagers profoundly. These interconnections occur in direct and indirect ways and are often subtle, but that does not make them less important; it only makes the challenge of governing such dynamics in the interests of marginalized working poor people even more difficult. In this paper, we focus our analysis on indirect and subtle interconnections. Examining empirical cases in Northern Shan State in Myanmar, we conclude that these interconnections occur in at least three broad ways, in which climate change politics can be: (i) a trigger for land grabbing, (ii) a legitimating process for land grabs, or (iii) a de-legitimating process for people’s climate change mitigation and adaptation practices. These interconnections in turn stoke old and provoke new political axes of conflict within and between state and social force

Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

Background So far, more than 170 loci have been associated with circulating lipid levels through genomewide association studies (GWAS). These associations are largely driven by common variants, their function is often not known, and many are likely to be markers for the causal variants. In this study we aimed to identify more new rare and low-frequency functional variants associated with circulating lipid levels. Methods We used the 1000 Genomes Project as a reference panel for the imputations of GWAS data from ~60 000 individuals in the discovery stage and ~90 000 samples in the replication stage. Results Our study resu

Drug-gene interactions of antihypertensive medications and risk of incident cardiovascular disease: A pharmacogenomics study from the CHARGE consortium

Background Hypertension is a major risk factor for a spectrum of cardiovascular diseases (CVD), including myocardial infarction, sudden death, and stroke. In the US, over 65 million people have high blood pressure and a large proportion of these individuals are prescribed antihypertensive medications. Although large long-term clinical trials conducted in the last several decades have identified a number of effective antihypertensive treatments that reduce the risk of future clinical complications, responses to therapy and protection from cardiovascular events vary among individuals. Methods Using a genome-wide association study among 21,267 participants with pharmaceutically treated hypertension, we explored the hypothesis that genetic variants might influence or modify the effectiveness of common antihypertensive therapies on the risk ofmajor cardiovascular outcomes. The classes of drug treatments included angiotensin-converting enzyme inhibitors, beta-blockers, calcium channel blockers, and diuretics. In the setting of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, each study performed array-based genome-wide genotyping, imputed to HapMap Phase II reference panels, and used additive genetic models in proportional hazards or logistic regressionmodels to evaluate drug-gene interactions for each of four therapeutic drug classes. We used meta-analysis to combine study-specific interaction estimates for approximately 2 million single nucleotide polymorphisms (SNPs) in a discovery analysis among 15,375 European Ancestry participants (3,527 CVD cases) with targeted follow-up in a case-only study of 1,751 European Ancestry GenHAT participants as well as among 4,141 African-Americans (1,267 CVD cases). Results Although drug-SNP interactions were biologically plausible, exposures and outcomes were well measured, and power was sufficient to detect modest interactions, we did not identify any statistically significant interactions from the four antihypertensive therapy meta-analyses (Pinteraction > 5.0×10-8). Similarly, findings were null for meta-analyses restricted to 66 SNPs with significant main effects on coronary artery disease or blood pressure from large published genom

Genome-wide association meta-analysis of fish and EPA+DHA consumption in 17 US and European cohorts

Background: Regular fish and omega-3 consumption may have several health benefits and are recommended by major dietary guidelines. Yet, their intakes remain remarkably variable both within and across populations, which could partly owe to genetic influences. Objective: To identify common genetic variants that influence fish and dietary eicosapentaenoic acid plus docosahexaenoic acid (EPA+DHA) consumption. Design: We conducted genome-wide association (GWA) meta-analysis of fish (n = 86, 467) and EPA +DHA (n = 62, 265) consumption in 17 cohorts of European descent from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium Nutrition Working Group. Results from cohort-specific GWA analyses (additive model) for fish and EPA+DHA consumption were adjusted for age, sex, energy intake, and population stratification, and meta-analyzed separately using fixed-effect meta-analysis with inverse variance weights (METAL software). Additionally, heritability was estimated in 2 cohorts. Results: Heritability estimates for fish and EPA+DHA consumption ranged from 0.13

DNA methylation age is associated with an altered hemostatic profile in a multi-ethnic meta-analysis

Many hemostatic factors are associated with age and age-related diseases; however, much remains unknown about the biological mechanisms linking aging and hemostatic factors. DNA methylation is a novel means by which to assess epigenetic aging, which is a measure of age and the aging processes as determined by altered epigenetic states. We used a meta-analysis approach to examine the association between measures of epigenetic aging and hemostatic factors, as well as a clotting time measure. For fibrinogen, we performed European and African ancestry–specific meta-analyses which were then combined via a random effects meta-analysis. For all other measures we could not estimate ancestry-specific effects and used a single fixed effects meta-analysis. We found that 1-year higher extrinsic epigenetic age as compared with chronological age was associated with higher fibrinogen (0.004 g/L/y; 95% confidence interval, 0.001-0.007; P 5 .01) and plasminogen activator inhibitor 1 (PAI-1; 0.13 U/mL/y; 95% confidence interval, 0.07-0.20; P 5 6.6 3 1025) concentrations, as well as lower activated partial thromboplastin time, a measure of clotting time. We replicated PAI-1 associations using an independent cohort. To further elucidate potential functional mechanisms, we associated epigenetic aging with expression levels of the PAI-1 protein encoding gene (SERPINE1) and the 3 fibrinogen subunit-encoding genes (FGA, FGG, and FGB) in both peripheral blood and aorta intima-media samples. We observed associations between accelerated epigenetic aging and transcription of FGG in both tissues. Collectively, our results indicate that accelerated epigenetic aging is associated with a procoagulation hemostatic profile, and that epigenetic aging may regulate hemostasis in part via gene transcription