8 research outputs found
Interruption of Transmission of <i>Onchocerca volvulus</i> in the Southern Chiapas Focus, MĂ©xico
<div><p>Background</p><p>The Southern Chiapas focus of onchocerciasis in Southern Mexico represents one of the major onchocerciasis foci in Latin America. All 559 endemic communities of this focus have undergone semi-annual mass treatment with ivermectin since 1998. In 50 communities of this focus, ivermectin frequency shifted from twice to four times a year in 2003; an additional 113 communities were added to the quarterly treatment regimen in 2009 to achieve a rapid suppression of transmission.</p> <p>Methodology/Principal findings</p><p>In-depth epidemiologic and entomologic assessments were performed in six sentinel communities (which had undergone 2 rounds of ivermectin treatment per year) and three extra-sentinel communities (which had undergone 4 rounds of ivermectin treatment per year). None of the 67,924 <i>Simulium ochraceum</i> s.l. collected from this focus during the dry season of 2011 were found to contain parasite DNA when tested by polymerase chain reaction-enzyme-linked immunosorbent assay (PCR-ELISA), resulting in an upper bound of the 95% confidence interval (95%-ULCI) of the infective rate in the vectors of 0.06/2,000 flies examined. Serological assays testing for <i>Onchocerca volvulus</i> exposure conducted on 4,230 children 5 years of age and under (of a total population of 10,280 in this age group) revealed that 2/4,230 individuals were exposed to <i>O. volvulus</i> (0.05%; one sided 95% confidence interval = 0.08%).</p> <p>Conclusions/Significance</p><p>The in-depth epidemiological and entomological findings from the Southern Chiapas focus meet the criteria for interruption of transmission developed by the international community.</p> </div
Number of individuals with nodules in the Southern Chiapas focus, Mexico, 1995–2010.
<p>Number of individuals with nodules in the Southern Chiapas focus, Mexico, 1995–2010.</p
In-depth epidemiologic assessments in sentinel and extra-sentinel communities of the Southern Chiapas focus.
<p>In-depth epidemiologic assessments in sentinel and extra-sentinel communities of the Southern Chiapas focus.</p
Prevalence of IgG4 antibodies to Ov16 in the focus of Southern Chiapas, MĂ©xico.
<p>Prevalence of IgG4 antibodies to Ov16 in children 10 years of age and under from sentinel, extra-sentinel, and eight other communities, in migrant workers >15 years of age from three coffee fincas and in children 5 years of age and under from 4 districts in the focus of Southern Chiapas, MĂ©xico.</p>*<p>Skin biopsies were taken and tested by PCR; they contained no parasite DNA (unpublished data).</p
Map of the Southern Chiapas focus, MĂ©xico.
<p>The map of the Southern Chiapas focus shows the six sentinel (marked in yellow) and three extra-sentinel communities (marked in red) and the main rivers and tributaries that might serve as a source of black fly breeding. Map (right) of the Southern Mexico states showing the three onchocerciasis endemic foci.</p
Coverage rate with ivermectin of the eligible population of the Southern Chiapas focus.
<p>The coverage rate, expressed in percent and the 95%-confidence intervals, CIs, surrounding point estimate, with ivermectin of the eligible population of the Southern Chiapas focus, 1995–2011. The line at 85% indicates the coverage needed in a sustained fashion to interrupt transmission.</p
Number of new clinical cases of onchocerciasis in the Southern Chiapas focus, MĂ©xico.
<p>The number of new clinical cases of onchocerciasis (individuals diagnosed positive to Mazzotti reaction, nodules, or skin mf for the first time) in the Southern Chiapas focus, from 1989 to 2010.</p
Entomological parameters in the focus of Southern Chiapas, MĂ©xico.
<p>The seasonal <i>S. ochraceum</i> s.l. biting rate is the number of bites per person per season. Prevalence of infective flies is expressed as rate per 2,000 flies examined and seasonal transmission potential is the third-stage larvae per person per season. These entomological parameters were estimated during 2008 through 2011 in the sentinel, extra-sentinel and other communities in the focus of Southern Chiapas.</p>*<p>Value represents point estimate and value in parentheses represents 95%-confidence intervals, CIs (95% upper limit CI when zero) surrounding point estimate.</p