Additional file 1 of Altered DNA methylation in liver and adipose tissues derived from individuals with obesity and type 2 diabetes

Figure S1. Clustering of methylation data from tissue samples from individuals with obesity. Figure S2. Comparison of methylation averages among tissue types. Figure S3. Comparison of DMCs between different tissues. Figure S4. Differential gene expression. Table S1. List of DMCs in WB in the comparison between the DO and NDO groups. Table S2. List of DMCs in SAT in the comparison between the DO and NDO groups. Table S3. List of DMCs in VAT in the comparison between the DO and NDO groups. Table S4. List of DMCs in LT in the comparison between the DO and NDO groups. Table S5. Gene ontology enrichment analysis using the genes with DMCs in SAT. Table S6. Gene ontology enrichment analysis using the genes with DMCs in VAT. Table S7. Gene ontology enrichment analysis using the genes with DMCs in LT. Table S8. Differential gene expression in WB in the comparison between DO and NDO groups. Table S9. Differential gene expression in SAT in the comparison between DO and NDO groups. Table S10. Differential gene expression in VAT in the comparison between DO and NDO groups. Table S11. Differential gene expression in LT in the comparison between DO and NDO groups. Table S12. List of genes with correlation between alteration of DNA methylation and differential gene expression in WB. Table S13. List of genes with correlation between alteration of DNA methylation and differential gene expression in SAT. Table S14. List of genes with correlation between alteration of DNA methylation and differential gene expression in VAT. Table S15. List of genes with correlation between alteration of DNA methylation and differential gene expression in LT. Table S16. Gene ontology enrichment analysis using the genes with correlation between alteration of DNA methylation and differential gene expression. (PDF 3440 kb

Schematic phylogenetic tree for the haplotype D5a2a1.

Note: Bur: Buryat; Kaz: Kazak; Kir: Kirghiz; Tib: Tibetan; Uyg: Uyghur; The following sequences were obtained from the Phylotree Build 17.0 [46]: AP013256, AP008854, AP013197, AP010743, AP011023, AP008536, AP013256, and AP009424 are Japanese sequences; JF824956 is from China, but unknown ethnic origin; FJ383195 is from India; AY255162 is a Han Chinese sequence.</p

Map of Jetisuu and the sampling sites.

1. Engbekshi Kazak; 2. Talghar; 3. Ile; 4. Almati; 5. Karasay; 6. Jambil; 7. Balkash; 8. Karatal; 9. Köksuu; 10. Taldikorghan; 11. Eskeldi; 12. Kerbulak; 13. Panfilov; 14. Kegen; 15. Rayimbek.</p

Schematic phylogenetic tree for the haplogroup C4a1 mitochondrial genomes.

Note: Alt: Altaian; Bur: Buryat; Uyg: Uyghur; Kir: Kirghiz; Tib: Tibetan.</p

Results from Tajima’s Neutrality Test [33].

Results from Tajima’s Neutrality Test [33].</p

Number of individuals surveyed from each of the four clans and the sampling sites.

(XLSX)</p

Schematic phylogenetic tree for the haplogroup C5 mitochondrial genomes.

Note: Alt: Altaian; Bur: Buryat; Uyg: Uyghur; Kir: Kirghiz.</p

Information on whole mitochondrial genome sequences which used for comparison.

Information on whole mitochondrial genome sequences which used for comparison.</p

Mitochondrial genomes (N = 2074) from the Central Eurasia for comparative analyses.

(XLSX)</p

Schematic phylogenetic tree for the haplotype T2b.

Note: Kaz: Kazak; Hu: Hungarian; Rus: Russian; Tat: Tatar; Uyg: Uyghur; SU006 and SH105 are Jetisuu sequences; EU007872 and JQ798066 are sequences from the Phylotree Build 17.0 [46].</p