Presidential Report Card

Every four years we choose a president that has the responsibility of representing all of us, but many times each of the candidates do not come close to being anything we want them to be. The Presidential Report Card is a way to allow for us as the citizens to be the ones who determines what we want as our Commander in Chief. In this I explore the previous research done by others who looked at the greatness of former presidents, Presidential Acting that presidents do to remain in the presidency, and the partisanship that we have began to see as a growing issue in this country. Each president that is being talked about in this research has found themselves, in some manner, having to deal with these issues, but for them to be labeled as “Great” then we must put their work to the test. Being president is not the easiest job in the world, many people know that, but this role requires unwavering effort on many fronts, and this shows in the legislation, bills, the advocacy that they do, and overall, how they seek to stand in the gap for the American people. Presidential Greatness for a long time has been a very talked about topic because greatness varies depending on the times that a president was in that determined the responses that they made for the situation, but what really needs to be questioned 2 is whether someone who made the greatness scales used their own personal political affiliation to determine the ratings? If this was not the case, then we need to find more ways to continue the work in evaluating presidential greatness, but if there was some partisanship in determining the numbers, then we need to go back and question if all these surveys have been using a fair ranking policy

Controlled levels of protein modification through a chromatography-mediated bioconjugation.

Synthetically modified proteins are increasingly finding applications as well-defined scaffolds for materials. In practice it remains difficult to construct bioconjugates with precise levels of modification because of the limited number of repeated functional groups on proteins. This article describes a method to control the level of protein modification in cases where there exist multiple potential modification sites. A protein is first tagged with a handle using any of a variety of modification chemistries. This handle is used to isolate proteins with a particular number of modifications via affinity chromatography, and then the handle is elaborated with a desired moiety using an oxidative coupling reaction. This method results in a sample of protein with a well-defined number of modifications, and we find it particularly applicable to systems like protein homomultimers in which there is no way to discern between chemically identical subunits. We demonstrate the use of this method in the construction of a protein-templated light-harvesting mimic, a type of system which has historically been difficult to make in a well-defined manner

Complete mitochondrial genome of six Cheilinusundulatus (Napoleon Wrasse): an endangeredmarine fish species from Sabah, Malaysia

We report here the complete mitochondrial (mt) genomes of six individuals of Cheilinus undulatus (Napoleon Wrasse), an endangered marine fish species. The six mt DNA sequences had an average size of 17,000 kb and encoded 22 tRNA, two sRNA, 13 highly conserved protein coding genes and a control region. The polymorphic variation (control region) in these six individuals suggests their potential use as a specific marker for phylogeographic conservation. Moreover, the sequence polymorphism within the control region (D-loop) suggests that this locus can be applied for phylogenetic studies

The Effect of Using Exoskeleton of Blue Crab (Callinectes sapidus) as a Dietary Calcium Source on the Egg Characteristics of Layer Hens (Gallus gallus domesticus)

The study focuses on the ability to use the exoskeleton of blue crab as alternative calcium and carotenoid supplement for layer hens and its effects on egg characteristics. Three groups of eighty layer hens each were fed a base feed formulation following the standards of the University of the Philippines Los Baños. The feeds were base feed as negative control (NG), a base feed with natural egg yolk colorants (capsorubin and lutein) as positive control (PG), and a base feed with 1% ground blue crab exoskeletons, as experimental (EG). The feeding lasted four weeks before egg collection. The eggs were weighed for their albumen, yolk, shell, and egg weight. The egg yolk color was determined using a DSM Fan and a digital Chroma meter, and the shell thickness using digital calipers. Statistical treatment was done through Kruskal Wallis test using SPSS software. Results showed that eggs of EG had significantly heavier shells with a mean of 5.93±0.11g, compared to 5.83±0.08g of the NG and 5.55±0.08g of the PG. Eggshell thickness was not significantly different among the three groups. Egg yolk color was significantly different in PG with a mean DSM gradient value of 11.96±0.11, compared to 5.92±0.14 of the NG and 6.48±0.20 of EG. Ground blue crab exoskeleton as a calcium supplement may increase the weight of the eggshells but may not intensify the egg yolk color

Self-Affirmation Activates Brain Systems Associated with Self-Related Processing and Reward and is Reinforced by Future Orientation

Self-affirmation theory posits that people are motivated to maintain a positive self-view and that threats to perceived self-competence are met with resistance. When threatened, self-affirmations can restore self-competence by allowing individuals to reflect on sources of self-worth, such as core values. Many questions exist, however, about the underlying mechanisms associated with self-affirmation. We examined the neural mechanisms of self-affirmation with a task developed for use in a functional magnetic resonance imaging environment. Results of a region of interest analysis demonstrated that participants who were affirmed (compared with unaffirmed participants) showed increased activity in key regions of the brain’s self-processing (medial prefrontal cortex + posterior cingulate cortex) and valuation (ventral striatum + ventral medial prefrontal cortex) systems when reflecting on future-oriented core values (compared with everyday activities). Furthermore, this neural activity went on to predict changes in sedentary behavior consistent with successful affirmation in response to a separate physical activity intervention. These results highlight neural processes associated with successful self-affirmation, and further suggest that key pathways may be amplified in conjunction with prospection

Molecular Mechanics Simulations and Improved Tight-binding Hamiltonians for Artificial Light Harvesting Systems: Predicting Geometric Distributions, Disorder, and Spectroscopy of Chromophores in a Protein Environment

We present molecular mechanics {and spectroscopic} calculations on prototype artificial light harvesting systems consisting of chromophores attached to a tobacco mosaic virus (TMV) protein scaffold. These systems have been synthesized and characterized spectroscopically, but information about the microscopic configurations and geometry of these TMV-templated chromophore assemblies is largely unknown. We use a Monte Carlo conformational search algorithm to determine the preferred positions and orientations of two chromophores, Coumarin 343 together with its linker, and Oregon Green 488, when these are attached at two different sites (104 and 123) on the TMV protein. The resulting geometric information shows that the extent of disorder and aggregation properties, and therefore the optical properties of the TMV-templated chromophore assembly, are highly dependent on the choice of chromophores and protein site to which they are bound. We used the results of the conformational search as geometric parameters together with an improved tight-binding Hamiltonian to simulate the linear absorption spectra and compare with experimental spectral measurements. The ideal dipole approximation to the Hamiltonian is not valid since the distance between chromophores can be very small. We found that using the geometries from the conformational search is necessary to reproduce the features of the experimental spectral peaks

Decoding Guilty Minds

A central tenet of Anglo-American penal law is that in order for an actor to be found criminally liable, a proscribed act must be accompanied by a guilty mind. While it is easy to understand the importance of this principle in theory, in practice it requires jurors and judges to decide what a person was thinking months or years earlier at the time of the alleged offense, either about the results of his conduct or about some elemental fact (such as whether the briefcase he is carrying contains drugs). Despite the central importance of this task in the administration of criminal justice, there has been very little research investigating how people go about making these decisions, and how these decisions relate to their intuitions about culpability. Understanding the cognitive mechanisms that govern this task is important for the law, not only to explore the possibility of systemic biases and errors in attributions of culpability but also to probe the intuitions that underlie them. In a set of six exploratory studies reported here, we examine the way in which individuals infer others’ legally relevant mental states about elemental facts, using the framework established over fifty years ago by the Model Penal Code (“MPC”). The widely adopted MPC framework delineates and defines the four now-familiar culpable mental states: purpose, knowledge, recklessness, and negligence. Our studies reveal that with little to no training, jury-eligible Americans can apply the MPC framework in a manner that is largely congruent with the basic assumptions of the MPC’s mental state hierarchy. However, our results also indicate that subjects’ intuitions about the level of culpability warranting criminal punishment diverge significantly from prevailing legal practice; subjects tend to regard recklessness as a sufficient basis for punishment under circumstances where the legislatures and courts tend to require knowledge