Odds of Dementia or Mild Cognitive Impairment (MCI), According to Telomere Length

*<p>Odds ratios are adjusted for age and educational attainment.</p>†<p>Telomere length measured as relative telomere to single gene ratio in peripheral blood leukocytes. Shorter telomere length was defined as below the median in the population of those without any dementia or mild cognitive impairment.</p

Characteristics of Controls, Cases of Mild Cognitive Impairment (MCI), and Cases of Dementia

<p>Characteristics of Controls, Cases of Mild Cognitive Impairment (MCI), and Cases of Dementia</p

Additional file 1 of Multi-omics and pathway analyses of genome-wide associations implicate regulation and immunity in verbal declarative memory performance

Additional file 1: Supplemental Text. Table S1. Sample size and the number of SNPs in the paragraph delayed recall GWAS from each discovery and replication cohort. Table S2. Sample size and the number of SNPs in the word list delayed recall GWAS from each discovery and replication cohort. Table S3. Tissue-specific relationships between delayed recall test (PAR-dr and WL-dr) summary SNP associations and eQTLs and meQTLs. Table S4. Relationship Between Delayed Recall Summary Gene Associations and Transcription Factor Genes. Table S5. Significant Genes Associated with Paragraph Delayed Recall (PAR-dr) and Word List Delayed Recall (WL-dr). Table S6. Significant component genes in the six memory-associated pathways. Table S7. Homologous genes in memory-associated pathways for differential expression analysis. Figure S1. GWAS cohorts and microarray expression datasets. Figure S2. Design of the pathway analyses. Figure S3. Forest plots of significant pathway enrichment effects and p-values from discovery cohorts (Approach 1)