PCIG: a web-based application to explore immune–genomics interactions across cancer types

Cancer; Application; Genomic alterationsCáncer; Aplicación; Alteraciones genómicasCàncer; Aplicació; Alteracions genòmiquesMotivation Genomic alterations can modulate the tumor immunophenotype depending on their nature and tissue of origin. Although this immune–genomic interaction may shape disease progression and response to immunotherapy, the factors governing such dynamics and the influence of each tissue-specific context remain poorly understood. Results Here, we have developed the PanCancer ImmunoGenomics (PCIG) tool, a web-based resource that provides researchers with the opportunity to mine immunome–genome relationships across several cancer types using data from the Pan-Cancer Analysis of Whole-Genomes (PCAWG) study, which comprises >2,600 samples spanning across 20 different cancer primary sites. PCIG yields an integrative analysis of the crosstalk between somatic genomic alterations and different immune features, thus helping to understand immune response-related processes.This work was supported by the Instituto de Salud Carlos III and co-funded by the European Regional Development Fund (ERDF) [CPII18/00026, PI17/01304], the CIBEREHD and CIBERNED programs from Instituto de Salud Carlos III, the Agència de Gestió d’Ajuts Universitaris i de Recerca, Generalitat de Catalunya [2017 SGR 1035], and Fundación Científica de la Asociación Española Contra el Cáncer [GCB13131592CAST]. S.L. obtained a PFIS grant from Instituto de Salud Carlos III and co-funded by the European Regional Development Fund (ERDF) [FI18/00221]. R.E.F. is supported by a doctoral training grant from MICINN/MINECO [BES-2017-081286] and a mobility grant from Fundació Universitària Agustí Pedro i Pons. This article is based upon work from COST Action [CA17118] and supported by COST (European Cooperation in Science and Technology)