1 research outputs found
Niosomes as Biocompatible Scaffolds for the Multivalent Presentation of Tumor-Associated Antigens (TACAs) to the Immune System
Fully synthetic tumor-associated carbohydrate antigen
(TACA)-based
vaccines are a promising strategy to treat cancer. To overcome the
intrinsic low immunogenicity of TACAs, the choice of the antigens’
analogues and multivalent presentation have been proved to be successful.
Here, we present the preparation, characterization, and in
vitro screening of niosomes displaying multiple copies of
the mucin antigen TnThr (niosomes-7) or of TnThr mimetic 1 (niosomes-2). Unprecedentedly, structural differences,
likely related to the carbohydrate portions, were observed for the
two colloidal systems. Both niosomal systems are stable, nontoxic
and endowed with promising immunogenic properties