Clinical characteristics and laboratory parameters of children with and without atherogenic dyslipidemia.

<p>BMI, body mass index; BP, blood pressure; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol; ApoB, apolipoprotein B; ApoAI, apolipoprotein AI; hs-CRP, high sensitivity C Reactive Protein; HOMA-IR, homeostasis model assessment of IR index.</p><p>hs-CRP and adiponectin values are reported as median (interquartile range)</p><p>* p<0.05;</p><p>** p<0.01;</p><p>*** p<0.001</p><p>Clinical characteristics and laboratory parameters of children with and without atherogenic dyslipidemia.</p

Clinical characteristics and laboratory parameters of parents and siblings of children with and without atherogenic dyslipidemia.

<p>BMI, body mass index; BP, blood pressure; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol; ApoB, apolipoprotein B; ApoAI, apolipoprotein AI; hs-CRP, high sensitivity C Reactive Protein; HOMA-IR, homeostasis model assessment of IR index. hs-CRP and adiponectin values are reported as median (interquartile range)</p><p>* P<0.05;</p><p>** p<0.01;</p><p>*** p<0.001 between parents</p><p>^{<b>‡‡</b>} p<0.01;</p><p>^{<b>‡‡‡</b>} p<0.001 between siblings</p><p>Clinical characteristics and laboratory parameters of parents and siblings of children with and without atherogenic dyslipidemia.</p

Flow diagram for classification of children with atherogenic dyslipidemia.

<p>Flow diagram for classification of children with atherogenic dyslipidemia.</p

Prevalence in the cohort of probands with atherogenic dyslipidemia of non-synonymous exonic variants in the LPL gene.

<p>^<b>a</b>The name at protein level is without the pro-peptide.</p><p>n = number of variant alleles / number of total alleles</p><p>^<b>b</b>Frequency from database 1000 genomes EUR;</p><p>^<b>c</b>Frequency from ESP6500:European_American, the only available for L365V SNP.</p><p>Depending on the sample size and absolute frequencies in the contingency table:</p><p>^<b>d</b>Fisher exact test or</p><p>^<b>e</b>χ² was applied.</p><p>^# = annotations for the new variant are: NC_000008.11:g.19948306G>A; NG_008855.1:g.14236G>A; NM_000237.2:c.215G>A; NP_000228.1:p.Ser45Asn</p><p>* = statistically significant at indicated P level.</p><p>Prevalence in the cohort of probands with atherogenic dyslipidemia of non-synonymous exonic variants in the LPL gene.</p

Distribution of SI values at different ages, stratified for genotypes and sex.

<p>SI values and their 95% confidence intervals at different ages for homozygotes of both <i>NMU</i> rs6827359 and <i>ADRB2</i> rs1042713 risk alleles (CC+GG, dark grey) and homozygotes for non-risk alleles (TT+AA, light gray) in subgroups of boys (panel A, n = 620, carriers of CC+GG = 101) and girls (panel B, n = 572, carriers of CC+GG = 85). Graph was obtained using SAS software (PROC SGPLOT with LOESS statement, see text). Local regression method implies that statistical power decreases at extreme <i>x</i> values (larger confidence intervals).</p

Population characteristics.

<p>NA = Not Available.</p

Bone stiffness index values in children with different combination of <i>NMU</i> rs6827359 and <i>ADRB2</i> rs1042713 alleles.

<p>Stiffness index values are least square means computed in a glm analysis using the variable with the four genotypes as independent variable. P for interaction was computed for CC*GG. <i>P</i> value for the association with double homozygotes for risk alleles were reported (heterozygotes were excluded).</p

Haplotype frequencies in the whole sample and stratified for BMI categories (n = 4,528 with at least one SNP successfully genotyped; T0).

<p>Haplotype frequencies in the whole sample and stratified for BMI categories (n = 4,528 with at least one SNP successfully genotyped; T0).</p

Associations between <i>NMU</i> genotypes and haplotypes and BMI, other anthropometric parameters and BMI categories.

<p>Associations between <i>NMU</i> genotypes and haplotypes and BMI, other anthropometric parameters and BMI categories.</p

Anthropometric characteristics of N = 4,528 children with genotype data recruited at baseline of the IDEFICS study.

<p>Anthropometric characteristics of N = 4,528 children with genotype data recruited at baseline of the IDEFICS study.</p