One hundred forty pathogens detected by SeptiFast (SF) and/or blood culture (BC) in 1009 patients.

1<p><i>Streptococcus</i> spp. group includes <i>S. agalactiae, S. pyogenes, S. anginosus</i>, <i>S. bovis</i>, <i>S. constellatus</i>, <i>S. cristatus</i>, <i>S. gordonii</i>, <i>S. intermedius, S. milleri, S. mitis, S. mutans, S. oralis, S. parasanguinis, S. salivarius, S. sanguinis, S. thermophilus, S. vestibularis, S. viridans</i>.</p>2<p>Coagulase-negative staphylococci group includes <i>S. epidermidis, S. haemolyticus, S. hominis, S. pasteuri, S. warneri, S. cohnii, S. lugdunensis, S. capitis, S. caprae, S. saprophyticus</i>, and <i>S. xylosus</i>.</p>3<p>ND, not included in the SF master list <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0053279#pone.0053279-Lehmann1" target="_blank">[6]</a>.</p

Sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, negative likelihood ratio of different cut-off values of PCT on SeptiFast results.

<p>PPV = positive predictive value.</p><p>NPV = negative predictive value.</p><p>LR+ = positive likelihood ratio.</p><p>LR− = negative likelihood ratio.</p

ROC curves for SeptiFast and blood cultures results according to different cut-off of PCT.

<p>SeptiFast: Area Under the Curve (AUC) = 0.927; 95% confidence interval (CI): 0.899–0.955, p<0.0001 (panel A). Blood culture: AUC = 0.820; 95% CI: 0.769–0.870, p>0.0001 (panel B).</p