Heatmap indicating alteration status for 942 cells for the top 25 most frequent oncogenic, predicted oncogenic, and likely oncogenic alterations in the CRC dataset.

Alterations are annotated using OncoKB. Absence of an alteration is noted when a cell has a read depth of at least 5 for all bases corresponding to the residue. For residues without an oncogenic alteration and with read depths less than 5 for all corresponding bases, the presence or absence of an alteration is not characterized (“Insufficient coverage”). (TIF)</p

Heatmaps showing the intersection sizes of genomic variants found in single cells and each patient’s respective WES samples.

(TIF)</p

Decomposing curves for <i>Ulva</i> detritus in lugworm excluded (treatment A−; square symbols in the graphs) or procedural control sediments (treatment A+; triangle symbols in the graph).

<p>Symbols indicate mean (± SE) for macroalgal biomass and are relative to experiments 2.</p

Two-way analyses of variance for sediment-water exchanges of O₂ and TCO₂ and for the benthic respiratory coefficient RQ.

<p>Significant values (<i>P</i><0.05) are in bold. Data were not-transformed (<i>P</i>_C-cochran >0.05), except for O_2, which was arc-tangent transformed to homogenise the residual variances. Asterisk indicates pooling of interaction when <i>P</i>>0.25.</p

Two-way analyses of variance for chlorophyll <i>a,</i> macrofauna abundance and number (N) of species.

<p>Significant values (<i>P</i><0.05) are in bold. Data were sqrt-transformed for macrofauna abundance.</p

Comparison of sediment surface appearance after <i>Arenicola marina</i> exclusion at low tide.

<p>A− represent the sediment after 1 month from the burial of net to exclude burrowing species. A+ is the procedural control treatment (see Materials and Methods for details).</p

Repeated measure analyses of variance and sphericity tests for the ¹³C incorporation in macrofauna and bulk sediment, and for the ¹³CO₂ released from the benthos (benthic respiration) during detrital decomposition at an intermediate level of detrital enrichment (200 gWW plot⁻¹added twice).

<p>Significant values (P<0.05) are in bold. Sphericity test was not significant.</p

Mean (+1SE) for (a) benthic oxygen (O₂) consumption and total carbon dioxide (TCO₂) released during 12 hours dark incubation; (b) Respiratory quotient (RQ).

<p>In the graphs, A−: <i>A. marina</i> excluded; A+: procedural control for burial; the legend indicate the levels of detrital addition (0: no addition; 200∶200 g WW were added twice at a 1 week interval; 600∶600 g WW were added twice with a 1 week interval). Data were sampled one month after detrital addition.</p

Mean ± SE for (a) T¹³CO₂ released from the sediment to the water column (sum of dry and wet fluxes); (b) amount of ¹³C organic carbon in the bulk sediment (averaged over depth profile) and (c) amount of ¹³C carbon incorporated by macrofauna.

<p>Data are fitted to the LOESS smoothing with an interval of 4 and 1 polynomial degree. Values are averaged over the two plots where <i>A. marina</i> was excluded (treatment A−; square symbols in the graphs) and the two procedural control plots (treatment A+; triangle symbols in the graph). Data refers to the experiment 2. Asterisk indicates significant differences.</p

Mean (+1SE) for (a) bulk sediment organic carbon (OC) and (b) porewater dissolved inorganic carbon (DIC) at different sediment depths (<i>1 cm</i>: surface sediment to 1 cm depth; <i>2 cm</i>: from the depth of 1 to 2 cm; <i>6 cm:</i> from the depth of 2 to 6 cm).

<p>In the graphs, A−: <i>A. marina</i> excluded; A+: procedural control for burial; the legend indicate the levels of detrital addition (0: no addition; 200∶200 g WW were added twice at a 1 week interval; 600∶600 g WW were added twice with a 1 week interval). Data were sampled one month after detrital addition. Asterisk indicates significant differences.</p