Clinical characteristics of the patients (probands and whole cohort) according to <i>MEN1</i> genotype.

<p>Clinical characteristics of the patients (probands and whole cohort) according to <i>MEN1</i> genotype.</p

Literature studies investigating <i>MEN1</i> gene large deletions using different analysis methodologies.

<p>Literature studies investigating <i>MEN1</i> gene large deletions using different analysis methodologies.</p

Tissue-selectivity of tumors in familial and sporadic MEN1 probands.

<p>Tissue-selectivity of tumors in familial and sporadic MEN1 probands.</p

MEN1 manifestations in the groups of F-MEN1, S-MEN1 probands and <i>MEN1</i> mutation-negative and mutation-positive probands.

<p>(<b>A</b>) Association of the main MEN1-related tumors and tumor aggressiveness in probands with F-MEN1 and S-MEN1 syndrome. (<b>B)</b> Association of the main MEN1-related tumors and tumor aggressiveness in patients of the whole cohort with F-MEN1 and S-MEN1 syndrome. (<b>C)</b> Association of the main MEN1-related tumors in <i>MEN1</i> mutation-positive and mutation-negative probands. <b>(D)</b> Detection rate of <i>MEN1</i> gene mutations within each main clinical presentation in <i>MEN1</i> mutation-positive probands with and without family history. Aty-MEN1 refers to atypical MEN1. Statistical significance was determined by Fisher or Chi-square test. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001.</p

<i>MEN1</i> gene mutations detected in 54 probands with MEN1 syndrome.

<p><i>MEN1</i> gene mutations detected in 54 probands with MEN1 syndrome.</p