1 research outputs found
NMR as Evaluation Strategy for Cellular Uptake of Nanoparticles
Advanced
nanostructured materials, such as gold nanoparticles, magnetic nanoparticles,
and multifunctional materials, are nowadays used in many state-of-the-art
biomedical application. However, although the engineering in this
field is very advanced, there remain some fundamental problems involving
the interaction mechanisms between nanostructures and cells or tissues.
Here we show the potential of <sup>1</sup>H NMR in the investigation
of the uptake of two different kinds of nanostructures, that is, maghemite
and gold nanoparticles, and of a chemotherapy drug (Temozolomide)
in glioblastoma tumor cells. The proposed experimental protocol provides
a new way to investigate the general problem of cellular uptake for
a variety of biocompatible nanostructures and drugs