Dynamical correlations in the escape strategy of Influenza A virus

The evolutionary dynamics of human Influenza A virus presents a challenging theoretical problem. An extremely high mutation rate allows the virus to escape, at each epidemic season, the host immune protection elicited by previous infections. At the same time, at each given epidemic season a single quasi-species, that is a set of closely related strains, is observed. A non-trivial relation between the genetic (i.e., at the sequence level) and the antigenic (i.e., related to the host immune response) distances can shed light into this puzzle. In this paper we introduce a model in which, in accordance with experimental observations, a simple interaction rule based on spatial correlations among point mutations dynamically defines an immunity space in the space of sequences. We investigate the static and dynamic structure of this space and we discuss how it affects the dynamics of the virus-host interaction. Interestingly we observe a staggered time structure in the virus evolution as in the real Influenza evolutionary dynamics.Comment: 14 pages, 5 figures; main paper for the supplementary info in arXiv:1303.595

Loss separation for dynamic hysteresis in magnetic thin films

We develop a theory for dynamic hysteresis in ferromagnetic thin films, on the basis of the phenomenological principle of loss separation. We observe that, remarkably, the theory of loss separation, originally derived for bulk metallic materials, is applicable to disordered magnetic systems under fairly general conditions regardless of the particular damping mechanism. We confirm our theory both by numerical simulations of a driven random--field Ising model, and by re--examining several experimental data reported in the literature on dynamic hysteresis in thin films. All the experiments examined and the simulations find a natural interpretation in terms of loss separation. The power losses dependence on the driving field rate predicted by our theory fits satisfactorily all the data in the entire frequency range, thus reconciling the apparent lack of universality observed in different materials.Comment: 4 pages, 6 figure

Phase transitions in a disordered system in and out of equilibrium

The equilibrium and non--equilibrium disorder induced phase transitions are compared in the random-field Ising model (RFIM). We identify in the demagnetized state (DS) the correct non-equilibrium hysteretic counterpart of the T=0 ground state (GS), and present evidence of universality. Numerical simulations in d=3 indicate that exponents and scaling functions coincide, while the location of the critical point differs, as corroborated by exact results for the Bethe lattice. These results are of relevance for optimization, and for the generic question of universality in the presence of disorder.Comment: Accepted for publication in Phys. Rev. Let

The average shape of a fluctuation: universality in excursions of stochastic processes

We study the average shape of a fluctuation of a time series x(t), that is the average value _T before x(t) first returns, at time T, to its initial value x(0). For large classes of stochastic processes we find that a scaling law of the form _T = T^\alpha f(t/T) is obeyed. The scaling function f(s) is to a large extent independent of the details of the single increment distribution, while it encodes relevant statistical information on the presence and nature of temporal correlations in the process. We discuss the relevance of these results for Barkhausen noise in magnetic systems.Comment: 5 pages, 5 figures, accepted for publication in Phys. Rev. Let