1 research outputs found
Kaempferol as Selective Human MAOāA Inhibitor: Analytical Detection in Calabrian Red Wines, Biological and Molecular Modeling Studies
The purpose of this work was to determine
the kaempferol content
in three red wines of Calabria, a southern Italian region with a great
number of certified food products. Considering that wine cultivar,
climate, and soil influence the qualitative and quantitative composition
in flavonoids of Vitis vinifera L.
berries, the three analyzed samples were taken from the 2013 vintage.
Moreover, the Gaglioppo samples, with assigned Controlled Origin Denomination
(DOC), were also investigated in the production of years 2008, 2010,
and 2011. In addition to the analysis of kaempferol, which is present
in higher concentration than in other Italian wines, in vitro assays
were performed to evaluate, for the first time, the inhibition of
the human monoamine oxidases (hMAO-A and hMAO-B). Molecular recognition
studies were also carried out to provide insight into the binding
mode of kaempferol and selectivity of inhibition of the hMAO-A isoform