SNPs associated with ILC (P<5×10⁻⁸) or LCIS (P<0.05) in a pooled lobular analysis (GLACIER and BCAC).

<p>SNPs associated with ILC (P<5×10⁻⁸) or LCIS (P<0.05) in a pooled lobular analysis (GLACIER and BCAC).</p

rs11977670, chromosome 7:139942304 G>A, and association ILC in populations of European ancestry.

<p>rs11977670, chromosome 7:139942304 G>A, and association ILC in populations of European ancestry.</p

SNPs showing differential lobular and ductal associations with breast cancer risk in BCAC subjects (ER+ tumours only).

<p>SNPs showing differential lobular and ductal associations with breast cancer risk in BCAC subjects (ER+ tumours only).</p

Association with risk of breast cancer for rs11977670 stratified by breast cancer tumour subtypes (Pooled analysis, BCAC, GLACIER, UK PHASE II).

<p>Association with risk of breast cancer for rs11977670 stratified by breast cancer tumour subtypes (Pooled analysis, BCAC, GLACIER, UK PHASE II).</p

Forest plot for rs11977670.

<p>Forest plot for rs11977670.</p

Lobular cancer study design.

<p>Lobular cancer study design.</p

Workflow of miRNA SNP selection.

<p>Workflow of miRNA SNP selection.</p

The 42 studied SNPs in miRNAs, miRNA machinery genes and miRNA target genes.

<p>Tag SNPs used in the analysis are presented in the parenthesis along with the R squred value relative to the functional SNP.</p>a<p>According to Patrocles prediction; AC  =  abolishes conserved binding site, ANC  =  abolishes non-conserved binding site, CNC  =  creates non-conserved binding site (Target sites are considered conserved if they are shared by at least one primate, one rodent and one nonprimate/nonrodent mammal <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0109973#pone.0109973-Hiard1" target="_blank">[24]</a>).</p><p>The 42 studied SNPs in miRNAs, miRNA machinery genes and miRNA target genes.</p