Expression of VE-Cadherin in Peritubular Endothelial Cells during Acute Rejection after Human Renal Transplantation

Genes involved in acute rejection (AR) after organ transplantation remain to be further elucidated. In a previous work we have demonstrated the under-expression of VE-Cadherin by endothelial cells (EC) in AR following murine and human heart transplantation. Serial sections from 15 human kidney Banff-graded transplant biopsies were examined for the presence of VE-Cadherin and CD34 staining by immunohistochemistry (no AR (n = 5), AR grade IA (n = 5), or AR grade IIA (n = 5)). Quantification of peritubular EC staining were evaluated and results were expressed by the percentage of stained cells per surface analysed. There was no difference in CD34 staining between the 3 groups. VE-Cadherin expression was significantly reduced in AR Grade IIA when compared to no AR (P = .01) and to AR grade IA (P = .02). This study demonstrates a reduced VE-Cadherin expression by EC in AR after renal transplantation. The down-regulation of VE-Cadherin may strongly participate in human AR

Interstitial lung disease associated with adult niemann-pick disease type B

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Lung-limited or lung-dominant variant of eosinophilic granulomatosis with polyangiitis

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Les tumeurs neuroendocrines du thymus : À propos de 6 cas

National audienceAim: the aim of our study was to analyze a series of 6 thymic neuroendocrine tumors (TNET). Methods: we report the clinical and pathological features of 6 TNET reclassified according to the last WHO classification (2004). Results: there were 4 men and 2 women, (mean age of 61.3 years), presenting with local symptoms in 4 cases. The tumors were reclassified as 3 atypical carcinoids (AC), 2 small cell carcinomas (SCC) and 1 large cell neuroendocrine carcinoma (LCNEC). Cytokeratin, EMA and neuroendocrine markers were expressed in poorly-differentiated tumors. Two patients were lost of follow-up. Two patients with AC died of disease at 20 and 36 months. One patient with SCC died of disease at 2 years and the patient with the LCNEC died of disease in 3 months. Conclusion:TNET are poor prognosis tumors with a prognosis similar to thymic carcinomas. Adequate surgical resection is a strong prognosis factor.Objectifs : l’objectif de ce travail était l’étude de 6 tumeurs neuroendocrines du thymus (TNET). Méthodes : nous rapportons les données cliniques, anatomo-pathologiques et évolutives de 6 TNET reclassées selon la dernière classification OMS (2004). Résultats : il s’agissait de 4 hommes et 2 femmes, âgés en moyenne de 61,3 ans avec des signes locaux dans 4 cas. Les tumeurs étaient classées en 3 carcinoïdes atypiques (CA), 2 carcinomes à petites cellules (CPC) et 1 carcinome neuroendocrine à grandes cellules (CNEGC). Les pancytokératines, l’EMA et les marqueurs neuroendocrines étaient exprimés par les carcinomes peu différenciés. Deux patients ont été perdus de vue. Les 2 patients porteurs d’un CA sont décédés de leur maladie à 20 et 36 mois. Le patient avec un CPC est décédé de sa maladie à 2 ans et le patient porteur du CNEGC est décédé à 3 mois. Conclusion : les TNET sont des tumeurs de mauvais pronostic avec un pronostic proche des carcinomes thymiques. La qualité de l’exérèse chirurgicale est un facteur pronostique majeur

Insuffisance respiratoire avec bronchectasies diffuses et atteinte alvéolocapillaire par dépôts immunoglobuliniques non amyloïdes

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Unusual Bilateral Acinar Nodules : Case for Diagnosis

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Improvement of refractory rheumatoid arthritis-associated constrictive bronchiolitis with etanercept

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Clubbing, arthralgia and a large intrathoracic mass

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Focal myositis

International audienceObjective To better define in a cohort study the clinical and pathologic features of focal myositis (FM). Methods With the use of the usual clinicopathologic definition, each confirmed case of FM in the Lyon University Hospital's myopathologic database between 2000 and 2016 was retrieved. Clinical, pathologic, imaging, serologic, and therapeutic data were collected. When data were missing but feasible, appropriate pathologic analyses were performed. Results Of the 924 patients included in the database, 37 (4%) had confirmed FM (14 female, 23 male patients). The main symptoms were pain (n = 30, 81%), muscular mass (n = 16, 43%), erythema at the site of FM (n = 12, 32%), and fever (n = 9, 24%). Serum creatine kinase was normal in most patients (81%); serum immune abnormalities were frequent (inflammatory syndrome in sera [39%], dysglobulinemia [52%], and anti-nuclear antibody positivity [29%]). In addition to confirming previously reported findings, pathologic analyses found significant rates of vasculitis (68%) and fasciitis (73%). Here, FM appeared frequently to be associated with other diseases such as immune-mediated inflammatory disease (IMID; 32%), neoplasia (24%), and radiculopathy (11%). Regarding outcomes, 64% of the cases had received immunosuppressive drugs, and the relapse rate was 41%. Conclusion The present study suggests that FM is not as innocuous as previously believed, particularly considering the associated disorders. Notably, patients with FM should receive careful IMID and neoplasia screening