Thermodynamic force versus PD3 probability relationship.

<p>There was a negative linear relationship between thermodynamic force and PD3 probability. Thermodynamic force = 1.2–12.2 PD3; r = 0.99.</p

Mechanical parameters of smooth and striated muscles and thermodynamic parameters previously published in the literature with the same method [9,10].

<p>Affinity of the CB cycle (J/mol); Thermodynamic force (J/mol/T); Thermodynamic flow (mol/L/s); EPR: Entropy production rate (J/T/L/s); S: Statistical entropy (J/mol/T); E: Internal energy (J/mol)); z: microcanonical partition function (dimensionless); k_cat: catalytic constant (s^-1); myosin content (nM/L). Values are means ± SD. EDL, Soleus and Trachea were stimulated under tetanic electrical stimulation and Heart under twitch electrical stimulation.</p><p>Mechanical parameters of smooth and striated muscles and thermodynamic parameters previously published in the literature with the same method [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0142471#pone.0142471.ref009" target="_blank">9</a>,<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0142471#pone.0142471.ref010" target="_blank">10</a>].</p

Thermodynamic force versus thermodynamic flow relationship.

<p>Thermodynamic force varied linearly with thermodynamic flow. The linear fit was thermodynamic force = 0.112 + (3.97. 10^-12) thermodynamic flow; r = 0.84.</p

Entropy production rate versus thermodynamic flow relationship.

<p>Entropy production rate varied linearly with thermodynamic flow. The linear fit was entropy production rate = (- 9.9. 10^-13) + 5.2 thermodynamic flow; r = 0.91.</p

Entropy production rate versus microcanonical partition function.

<p>There was a curvilinear relationship between entropy production rate and microcanonical partition function.</p

Study population at baseline.

<p>Values expressed as mean (SD) or n (%). BMI = body mass index, LTOT = long-term oxygen therapy, OHS = obesity hypoventilation syndrome, ICU = intensive care unit, FEV₁ = forced expiratory volume in 1 s, FVC = forced vital capacity, IPAP = inspiratory partial airway pressure, EPAP = expiratory partial airway pressure, Min RR = minimal respiratory rate</p><p>Study population at baseline.</p

Predictive factors for adherence in patients aged ≥ 75.

<p>OHS: obesity hypoventilation syndrome, MMSE: mini mental state examination</p><p>Predictive factors for adherence in patients aged ≥ 75.</p

Comparison of the impact of NIV on HRQL evaluated by SF-36 in patients aged < 75 years or ≥ 75 years.

<p>Values expressed as mean (SD).</p><p>Δ: variation between baseline and 6 months</p><p>*p value < 0.05</p><p>^‡p value for comparison of Δ between ≥ 75 and < 75</p><p>PCS: physical component summary, MCS: mental component summary</p><p>Comparison of the impact of NIV on HRQL evaluated by SF-36 in patients aged < 75 years or ≥ 75 years.</p

Comparison of NIV efficacy at 6 months in patients aged < 75 years or ≥ 75 years.

<p>Δ: variation between baseline and 6 months</p><p>*p value < 0.05</p><p>^†percentage of patients with initial Epworth scale score over 10</p><p>^§ percentage of patients with initial Pittsburgh sleep quality index over 7</p><p>^‡p value for comparison of Δ between ≥ 75 and < 75</p><p>ESS: Epworth scale score, PSQI: Pittsburgh sleep quality index</p><p>Comparison of NIV efficacy at 6 months in patients aged < 75 years or ≥ 75 years.</p

Efavirenz plasma concentrations at sampling time.

<p>Efavirenz plasma concentrations at sampling time.</p