5 research outputs found
Bland Altman plot of comparison of Method 1 (Autodelphia) used by centre 1,2,3,4 versus Method 2 (ELISA commercial Biorad) used by centre 5.
<p>Mean difference: −3.854 mU/L (CI −4.291 to −3.417 mU/L) (left) and method 1 (Autodelphia) used by centre 1,2,3,4 versus method 3 (ELISA) used by centre 6; mean difference: −1.470 mU/L (CI −1.692 to −1.249 mU/L) (right).</p
Distribution of TSH values (between 0 and 15 mU/L) over the three different years by the six different scenarios.
***<p>P<0.05 for all Tukey tests comparing differences in TSH levels over the years 2009, 2010, 2011. TSH1: TSH values of centre 5 and 6 converted to Autodelphia method using point estimators for intercept and slope. TSH2: TSH values of centre 5 and 6 converted to Audodelphia method using lower limit of CI for intercept and slope. TSH3: TSH values of centre 5 and 6 converted to Autodelphia method using higher limit of CI for intercept and slope. TSH4: TSH values of centre 5 and 6 converted to Autodelphia method using lower limit of CI for intercept and higher limit of CI for slope. TSH5: TSH values of centre 5 and 6 converted to Autodelphia method using lower limit of CI for slope and higher limit of CI for intercept. TSH6: Only TSH values of 4 centres using Autodelphia method.</p
Regression equations and 95% CI to convert TSH levels of centre 5 and 6 to Autodelphia method.
<p>Centre 5: Liège; Centre 6: Louvain en Woluwé. CI confidence interval.</p
Least square means of difference in TSH among years and seasons, linear mixed model regression.
*<p>transformed values.</p
Additional file 1: Figure S1. of Efficacy, safety and population pharmacokinetics of sapropterin in PKU patients <4Â years: results from the SPARK open-label, multicentre, randomized phase IIIb trial
Summary of neuromotor developmental milestones – ITT population. Data show (a) the proportion of patients with normal development in the area of assessment at baseline, (b) Week 12, and (c) Week 26 treated with sapropterin plus the Phe-restricted diet, or Phe-restricted diet alone. P-values show comparison of results between treatment groups at Week 26 using the chi-squared test. Table S1. PAH genotypes of sapropterin responders (n=37). (DOCX 180 kb