An investigation into the fate of certain halogenated hydrocarbon compounds in domesticated animals

The fate of carbon tetrachloride and hexachloroethane was studied in sheep, rabbits, cockerels, ducks and liver flukes. A new method was described for detection and estimation of hexachloroethane and its metabolites pentachloroethane and tetrachloroethylene in biological extracts using a multicolumn gas-liquid chromatographic technique. Pentachloroethane had not prieviously been reported as a metabolite of hexachloroethane and was itself metabolised to tetrachloroethylene.A new metabolite of carbon tetrachloride, hexachloroethane, was described and may have arisen by dimerisation of free trichloromethyl radicals. Detection of the dimer of such radicals may provide evidence for the formation of trichloro¬ methyl radicals from carbon tetrachloride ; a current hypothesis suggests that the toxicity of the drug is due to liberation of these radicals in vivo.The biliary excretion of carbon tetrachloride and hexachloroethane in several species including sheep was studied.The effect of carbon tetrachloride, hexachloroethane, penta¬ chloroethane, tetrachloroathylene, tetrachlorodifluoroethanes and bistrichloromethylbenzene on plasma enzyme activities in sheep was studied. Carbon tetrachloride and hexachloroethane were hepatotoxic in sheep, but probably not in cockerels and ducks. Hepatotoxicity due to hexachloroethane had not priev¬ iously been described and was detected by elevation of plasma enzyme activity and reduced bromsulphthalein dye transfer rates.The hepatotoxicity of carbon tetrachloride for sheep and tolerance of cockerels and ducks to the drug was discussed.The in-vitro toxicity on liver flukes of various substances was studied. Liver flukes metabolised carbon tetrachloride and hexachloroethane in vitro. Carbon tetrachloride, carbon tetrachloride treated liver lipid and a carbon tetrachloridemethyl oleate complex were toxic to liver flukes in vitro, in the presence of sheep bile.The fasciocidal action of carbon tetrachloride was discussed and related to the toxicity of the drug in mammals

How many sigmas is the solar neutrino effect?

The minimal standard electroweak model can be tested by allowing all the solar neutrino fluxes, with undistorted energy spectra, to be free parameters in fitting the measured solar neutrino event rates, subject only to the condition that the total observed luminosity of the sun is produced by nuclear fusion. The rates of the five experiments prior to SNO (chlorine, Kamiokande, SAGE, GALLEX, Super-Kamiokande) cannot be fit by an arbitrary choice of undistorted neutrino fluxes at the level of 2.5 sigma (formally 99% C.L.). Considering just SNO and Super-Kamiokande, the discrepancy is at the 3.3 sigma level(10^{-3} C.L.). If all six experiments are fit simultaneously, the formal discrepancy increases to 4 sigma (7*10^{-5} C.L.). If the relative scaling in temperature of the nuclear reactions that produce 7Be and 8B neutrinos is taken into account, the formal discrepancy is at the 7.4 sigma level.Comment: 1 figure; related information at http://www.sns.ias.edu/~jn

The luminosity constraint on solar neutrino fluxes

A specific linear combination of the total solar neutrino fluxes must equal the measured solar photon luminosity if nuclear fusion reactions among light elements are responsible for solar energy generation. This luminosity constraint, previously used in a limited form in testing the no neutrino oscillation hypothesis, is derived in a generality that includes all of the relevant solar neutrino fluxes and which is suitable for analyzing the results of many different solar neutrino experiments. With or without allowing for neutrino oscillations, the generalized luminosity constraint can be used in future analyses of solar neutrino data. Accurate numerical values for the linear coefficients are provided.Comment: related material at http://www.sns.ias.edu/~jn

IONS FOR LHC: STATUS OF THE INJECTOR CHAIN

The LHC will, in addition to proton runs, be operated with Pb ions and provide collisions at energies of 5.5 TeV per nucleon pair, i.e. more than 1.1 PeV per event, to experiments. The transformation of CERN's ion injector complex (Linac3-LEIR-PS-SPS) to allow collision of ions in LHC in 2008 is well under way. The status of these modifications and the latest results of commissioning will be presented. The remaining challenges are reviewed

Evidence for dark energy from the cosmic microwave background alone using the Atacama Cosmology Telescope lensing measurements

For the first time, measurements of the cosmic microwave background radiation (CMB) alone favor cosmologies with $w=-1$ dark energy over models without dark energy at a 3.2-sigma level. We demonstrate this by combining the CMB lensing deflection power spectrum from the Atacama Cosmology Telescope with temperature and polarization power spectra from the Wilkinson Microwave Anisotropy Probe. The lensing data break the geometric degeneracy of different cosmological models with similar CMB temperature power spectra. Our CMB-only measurement of the dark energy density $\Omega_\Lambda$ confirms other measurements from supernovae, galaxy clusters and baryon acoustic oscillations, and demonstrates the power of CMB lensing as a new cosmological tool.Comment: 4 pages, 3 figures; replaced with version accepted by Physical Review Letters, added sentence on models with non-standard primordial power spectr

The Atacama Cosmology Telescope: Sunyaev-Zel'dovich Selected Galaxy Clusters at 148 GHz from Three Seasons of Data

[Abridged] We present a catalog of 68 galaxy clusters, of which 19 are new discoveries, detected via the Sunyaev-Zel'dovich effect (SZ) at 148 GHz in the Atacama Cosmology Telescope (ACT) survey of 504 square degrees on the celestial equator. A subsample of 48 clusters within the 270 square degree region overlapping SDSS Stripe 82 is estimated to be 90% complete for M_500c > 4.5e14 Msun and 0.15 < z < 0.8. While matched filters are used to detect the clusters, the sample is studied further through a "Profile Based Amplitude Analysis" using a single filter at a fixed \theta_500 = 5.9' angular scale. This new approach takes advantage of the "Universal Pressure Profile" (UPP) to fix the relationship between the cluster characteristic size (R_500) and the integrated Compton parameter (Y_500). The UPP scalings are found to be nearly identical to an adiabatic model, while a model incorporating non-thermal pressure better matches dynamical mass measurements and masses from the South Pole Telescope. A high signal to noise ratio subsample of 15 ACT clusters is used to obtain cosmological constraints. We first confirm that constraints from SZ data are limited by uncertainty in the scaling relation parameters rather than sample size or measurement uncertainty. We next add in seven clusters from the ACT Southern survey, including their dynamical mass measurements based on galaxy velocity dispersions. In combination with WMAP7 these data simultaneously constrain the scaling relation and cosmological parameters, yielding \sigma_8 = 0.829 \pm 0.024 and \Omega_m = 0.292 \pm 0.025. The results include marginalization over a 15% bias in dynamical mass relative to the true halo mass. In an extension to LCDM that incorporates non-zero neutrino mass density, we combine our data with WMAP7+BAO+Hubble constant measurements to constrain \Sigma m_\nu < 0.29 eV (95% C. L.).Comment: 32 pages, 21 figures To appear in J. Cosmology and Astroparticle Physic

From Social Data Mining to Forecasting Socio-Economic Crisis

Socio-economic data mining has a great potential in terms of gaining a better understanding of problems that our economy and society are facing, such as financial instability, shortages of resources, or conflicts. Without large-scale data mining, progress in these areas seems hard or impossible. Therefore, a suitable, distributed data mining infrastructure and research centers should be built in Europe. It also appears appropriate to build a network of Crisis Observatories. They can be imagined as laboratories devoted to the gathering and processing of enormous volumes of data on both natural systems such as the Earth and its ecosystem, as well as on human techno-socio-economic systems, so as to gain early warnings of impending events. Reality mining provides the chance to adapt more quickly and more accurately to changing situations. Further opportunities arise by individually customized services, which however should be provided in a privacy-respecting way. This requires the development of novel ICT (such as a self- organizing Web), but most likely new legal regulations and suitable institutions as well. As long as such regulations are lacking on a world-wide scale, it is in the public interest that scientists explore what can be done with the huge data available. Big data do have the potential to change or even threaten democratic societies. The same applies to sudden and large-scale failures of ICT systems. Therefore, dealing with data must be done with a large degree of responsibility and care. Self-interests of individuals, companies or institutions have limits, where the public interest is affected, and public interest is not a sufficient justification to violate human rights of individuals. Privacy is a high good, as confidentiality is, and damaging it would have serious side effects for society.Comment: 65 pages, 1 figure, Visioneer White Paper, see http://www.visioneer.ethz.c

Corporate governance and financial constraints on strategic turnarounds

The paper extends the Robbins and Pearce (1992) two-stage turnaround response model to include governance factors. In addition to the retrenchment and recovery, the paper proposes the addition of a realignment stage, referring specifically to the re-alignment of expectations of principal and agent groups. The realignment stage imposes a threshold that must be crossed before the retrenchment and hence recovery stage can be entered. Crossing this threshold is problematic to the extent that the interests of governance-stakeholder groups diverge in a crisis situation. The severity of the crisis impacts on the bases of strategy contingent asset valuation leading to the fragmentation of stakeholder interests. In some cases the consequence may be that management are prevented from carrying out turnarounds by governance constraints. The paper uses a case study to illustrate these dynamics, and like the Robbins and Pearce study, it focuses on the textile industry. A longitudinal approach is used to show the impact of the removal of governance constraints. The empirical evidence suggests that such financial constraints become less serious to the extent that there is a functioning market for corporate control. Building on governance research and turnaround literature, the paper also outlines the general case necessary and sufficient conditions for successful turnarounds