Resveratrol improves mitochondrial energetic pathway and endothelial function in type 2 diabetic female rat heart submitted to ischemia-reperfusion injury

International audienceType 2 diabetic women present high risk of mortality by cardiovascular (CV) disease in comparison to non-diabetic women. Most of anti-diabetic treatments do not decrease patient’s CV mortality, therefore new approaches need to be found. Resveratrol (RSV) is a polyphenol found in grapes reported to be beneficial on oxidative stress, endothelial dysfunction andinflammation involved in CV complications of T2D

Sex-Mediated Response to the Beta-Blocker Landiolol in Sepsis: An Experimental, Randomized Study

OBJECTIVES: To investigate any gender effect of the beta-1 adrenergic blocker, landiolol, on cardiac performance and energy metabolism in septic rats, and to explore the expression of genes and proteins involved in this process. DESIGN: Randomized animal study. SETTING: University research laboratory. SUBJECTS: Male and female Wistar rats. INTERVENTIONS: One hour after cecal ligation and puncture, male and female rats were randomly allocated to the following groups: sham male, cecal ligation and puncture male, cecal ligation and puncture + landiolol male, sham female, cecal ligation and puncture female, and cecal ligation and puncture + landiolol female. Cardiac MRI was carried out 18 hours after cecal ligation and puncture to assess in vivo cardiac function. Ex vivo cardiac function measurement and P magnetic resonance spectroscopy were subsequently performed using an isovolumic isolated heart preparation. Finally, we assessed cardiac gene and protein expression. MEASUREMENTS AND MAIN RESULTS: In males, landiolol increased indexed stroke volume by reversing the indexed end-diastolic volume reduction without affecting left ventricle ejection fraction. In females, landiolol did not increase indexed stroke volume and indexed end-diastolic volume but decreased left ventricle ejection fraction. Landiolol had no effect on ex vivo cardiac function and on high-energy phosphate compounds. The effect of landiolol on the gene expression of natriuretic peptide receptor 3 and on protein expression of phosphorylated-AKT:AKT ratio and endothelial nitric oxide synthase was different in males and females. CONCLUSIONS: Landiolol improved the in vivo cardiac performance of septic male rats while deleterious effects were reported in females. Expression of natriuretic peptide receptor 3, phosphorylated-AKT:AKT, and endothelial nitric oxide synthase are signaling pathways to investigate to better understand the sex differences in sepsis

128 - Intolerance to glucose and abdominal obesity in a diet-induced metabolic syndrome model were associated with modification of cardiac morphology and impaired myocardial function

International audienceIntroduction Metabolic Syndrome (MetS) is defined by multiple risk factors that predict type 2 diabetes and cardiovascular complications, such as myocardial infarction, especially in women. Consequently the aim of this preliminary study was to investigate in vivo and ex vivo the effects of a high-fat-high-sucrose diet (HFHSD) on the development of metabolic syndrome (MetS), cardiac morphology and function of female Wistar rat

Resveratrol improves mitochondrial energetic pathway and endothelial function in type 2 diabetic female rat heart submitted to ischemia-reperfusion injury

International audienceType 2 diabetic women present high risk of mortality by cardiovascular (CV) disease in comparison to non-diabetic women. Most of anti-diabetic treatments do not decrease patient’s CV mortality, therefore new approaches need to be found. Resveratrol (RSV) is a polyphenol found in grapes reported to be beneficial on oxidative stress, endothelial dysfunction andinflammation involved in CV complications of T2D

Protective effect of Resveratrol against cardiac and endothelial dysfunctions of type 2 diabetic female GK rat heart submitted to ischaemia-reperfusion injury

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Greater impairment of energy metabolism and coronary flow in type 2 diabetic female rats than in male during myocardial ischemia-reperfusion injury

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Protective effect of Resveratrol against cardiac dysfunction and impaired energy metabolism of type 2 diabetic female GK rat heart submitted to Ischemia-Reperfusion injury

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