Risk as Social Context: Immigration Policy and Autism in California

Motivated by the dramatic increase in autism diagnoses in recent years, research into risk factors has uncovered substantial variation in autism prevalence by race/ethnicity, SES, and geography. Less studied is the connection between autism diagnosis rates and the social and political context. In this article, we link the temporal pattern of autism diagnosis for Hispanic children in California to state and federal anti‐immigrant policy, particularly ballot initiative Proposition 187, limiting access to public services for undocumented immigrants and their families. Using a population‐level data set of 1992–2003 California births linked to 1992–2006 autism case records, we show that the effects of state and federal policies toward immigrants are visible in the rise and fall of autism risk over time. The common epidemiological practice of estimating risk on pooled samples is thereby shown to obscure patterns and mis‐estimate effect sizes. Finally, we illustrate how spatial variation in Hispanic autism rates reflects differential vulnerability to these policies. This study reveals not only the spillover effects of immigration policy on children’s health, but also the hazards of treating individual attributes like ethnicity as risk factors without regard to the social and political environments that give them salience

Age of Diagnosis for Autism: Individual and Community Factors across 10 Birth Cohorts

The incidence of autism rose dramatically between 1992 and 2001, while the age at which children were first diagnosed declined. During this period the size and composition of the autism caseload has changed, but little is known about whether the factors associated with the timing of diagnosis may also have shifted. Using a multilevel analysis strategy, the individual and community-level factors associated with age of diagnosis were modelled across 10 birth cohorts of California children

Six Developmental Trajectories Characterize Children With Autism

The goal of this study was to describe the typical longitudinal developmental trajectories of social and communication functioning in children with autism and to determine the correlates of these trajectories

Estimated Autism Risk and Older Reproductive Age

The prevalence of autism, a developmental disorder characterized by serious impairments in social interaction and language development as well as stereotyped and repetitive behaviors, has increased dramatically over the past 2 decades from approximately 4 to 40 cases per 10 000. The cause of the increase is unknown, as is the etiology of autism. Evidence from twin studies suggests that autism is likely a genetic disorder. However, genetic causes for the vast majority of autism cases have not yet been identified through molecular genetic research. In addition, dozens of previous studies have identified a wide range of perinatal and parental risk factors. Despite these studies, our understanding of even the most basic of these factors, parental age, is muddled

Cohort effects explain the increase in autism diagnosis among children born from 1992 to 2003 in California

The incidence and prevalence of autism have dramatically increased over the last 20 years. Decomposition of autism incidence rates into age, period and cohort effects disentangle underlying domains of causal factors linked to time trends. We estimate an age-period-cohort effect model for autism diagnostic incidence overall and by level of functioning

Association Between Assisted Reproductive Technology Conception and Autism in California, 1997–2007

Objectives. We assessed the association between assisted reproductive technology (ART) and diagnosed autistic disorder in a population-based sample of California births. Methods. We performed an observational cohort study using linked records from the California Birth Master Files for 1997 through 2007, the California Department of Developmental Services autism caseload for 1997 through 2011, and the Centers for Disease Control and Prevention’s National ART Surveillance System for live births in 1997 through 2007. Participants were all 5 926 251 live births, including 48 865 ART-originated infants and 32 922 cases of autism diagnosed by the Department of Developmental Services. We compared births originated using ART with births originated without ART for incidence of autism.Results. In the full population, the incidence of diagnosed autism was twice as high for ART as non-ART births. The association was diminished by excluding mothers unlikely to use ART; adjustment for demographic and adverse prenatal and perinatal outcomes reduced the association substantially, although statistical significance persisted for mothers aged 20 to 34 years. Conclusions. The association between ART and autism is primarily explained by adverse prenatal and perinatal outcomes and multiple births

Does Autism Diagnosis Age or Symptom Severity Differ Among Children According to Whether Assisted Reproductive Technology was Used to Achieve Pregnancy?

Previous studies report associations between conception with assisted reproductive technology (ART) and autism. Whether these associations reflect an ascertainment or biologic effect is undetermined. We assessed diagnosis age and initial autism symptom severity among[30,000 children with autism from a linkage study of California Department of Developmental Services records, birth records, and the National ART Surveillance System. Median diagnosis age and symptom severity levels were significantly lower for ART-conceived than non-ART- conceived children. After adjustment for differences in the socio-demographic profiles of the two groups, the diagno- sis age differentials were greatly attenuated and there were no differences in autism symptomatology. Thus, ascer- tainment issues related to SES, not ART per se, are likely the driving influence of the differences we initially observed

Association of assisted reproductive technology (ART) treatment and parental infertility diagnosis with autism in ART-conceived children

The use of assisted reproductive technology (ART), which includes all procedures that involve handling of oocytes and sperm or embryos outside of the human body, has been increasing steadily since it was first introduced in 1978. Over 5 million children conceived with ART have been born globally (Adamson et al., 2013). About 1.5% of all infants born in the USA are conceived using ART (Sunderam et al., 2013). The effect of ART procedures on the health and development of children has been an area of special interest for researchers during the last three decades. However, studying the long-term outcomes of ART is difficult in part due to rapid technological progress in this relatively new field of medicine. Remarkable advances in embryo culture, cryopreservation of embryos and oocytes, ICSI, preimplantation genetic testing, and assisted hatching have led to the development of new treatment options. The safety—including long-term safety—of these new treatments requires careful study

Epidemiology of Haemophilus influenzae Serotype a, North American Arctic, 2000–2005

Serotype a is now the most common seen in the North American Arctic; highest rates occur in indigenous children

Epidemiology of Haemophilus influenzae Serotype a, North American Arctic, 2000–2005

Serotype a is now the most common seen in the North American Arctic; highest rates occur in indigenous children