Helping Clients find their True North: Increasing Client Engagement through In-Vivo Clinical Offerings and Collegiate Based Services

College participation and substance use disorder treatment do not need to, nor should they, be pursued in isolation from one another. Modern treatment opportunities exist which place an emphasis on school as a restorative and curative aspect of the treatment plan and encourage active class participation throughout the traditional treatment continuum. This interactive presentation will enhance participants' efficacy through reframing of clinical interventions through a Narrative Therapy lens in order to assist clients in finding their purpose through developmentally appropriate interventions, and the use of academics and "In-Vivo" offerings as an intervention to increase engagement in treatment. Adjusting our concept of a "continuum of care" to include real world experiences in order to challenge, empower, and inspire emerging adults; thereby creating a paradigm shift in the lives of recovering students in early stages of recovery

Identification of neural oscillations and epileptiform changes in human brain organoids

Brain organoids represent a powerful tool for studying human neurological diseases, particularly those that affect brain growth and structure. However, many diseases manifest with clear evidence of physiological and network abnormality in the absence of anatomical changes, raising the question of whether organoids possess sufficient neural network complexity to model these conditions. Here, we explore the network-level functions of brain organoids using calcium sensor imaging and extracellular recording approaches that together reveal the existence of complex network dynamics reminiscent of intact brain preparations. We demonstrate highly abnormal and epileptiform-like activity in organoids derived from induced pluripotent stem cells from individuals with Rett syndrome, accompanied by transcriptomic differences revealed by single-cell analyses. We also rescue key physiological activities with an unconventional neuroregulatory drug, pifithrin-α. Together, these findings provide an essential foundation for the utilization of brain organoids to study intact and disordered human brain network formation and illustrate their utility in therapeutic discovery