Ground Beetle Range Extensions: Six New Ohio Records (Coleoptera: Carabidae)

We newly report six ground beetles from Ohio, comprising Badister parviceps, Stenolophus dissimilis, Harpalus somnulentus, Pentagonica fiavipes, Agonum albicrus, and Lebia collaris

Pharmacologic and Bacteriologic Properties of SCH‐27899 (Ziracin), an Investigational Antibiotic from the Everninomicin Family

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90360/1/phco.19.15.1111.30576.pd

Link and subgraph likelihoods in random undirected networks with fixed and partially fixed degree sequence

The simplest null models for networks, used to distinguish significant features of a particular network from {\it a priori} expected features, are random ensembles with the degree sequence fixed by the specific network of interest. These "fixed degree sequence" (FDS) ensembles are, however, famously resistant to analytic attack. In this paper we introduce ensembles with partially-fixed degree sequences (PFDS) and compare analytic results obtained for them with Monte Carlo results for the FDS ensemble. These results include link likelihoods, subgraph likelihoods, and degree correlations. We find that local structural features in the FDS ensemble can be reasonably well estimated by simultaneously fixing only the degrees of few nodes, in addition to the total number of nodes and links. As test cases we use a food web, two protein interaction networks (\textit{E. coli, S. cerevisiae}), the internet on the autonomous system (AS) level, and the World Wide Web. Fixing just the degrees of two nodes gives the mean neighbor degree as a function of node degree, $_k$, in agreement with results explicitly obtained from rewiring. For power law degree distributions, we derive the disassortativity analytically. In the PFDS ensemble the partition function can be expanded diagrammatically. We obtain an explicit expression for the link likelihood to lowest order, which reduces in the limit of large, sparse undirected networks with $L$ links and with $k_{\rm max} \ll L$ to the simple formula $P(k,k') = kk'/(2L + kk')$. In a similar limit, the probability for three nodes to be linked into a triangle reduces to the factorized expression $P_{\Delta}(k_1,k_2,k_3) = P(k_1,k_2)P(k_1,k_3)P(k_2,k_3)$.Comment: 17 pages, includes 11 figures; first revision: shortened to 14 pages (7 figures), added discussion of subgraph counts, deleted discussion of directed network

Ground Beetle Range Extensions: Six New Ohio Records (Coleoptera: Carabidae)

We newly report six ground beetles from Ohio, comprising Badister parviceps, Stenolophus dissimilis, Harpalus somnulentus, Pentagonica fiavipes, Agonum albicrus, and Lebia collaris

Blur discrimination and its relation to blur-mediated depth perception

Retinal images of three-dimensional scenes often contain regions that are spatially blurred by different amounts, owing to depth variation in the scene and depth-of-focus limitations in the eye. Variations in blur between regions in the retinal image therefore offer a cue to their relative physical depths. In the first experiment we investigated apparent depth ordering in images containing two regions of random texture separated by a vertical sinusoidal border. The texture was sharp on one side of the border, and blurred on the other side. In some presentations the border itself was also blurred. Results showed that blur variation alone is sufficient to determine the apparent depth ordering. A subsequent series of experiments measured blur-discrimination thresholds with stimuli similar to those used in the depth-ordering experiment. Weber fractions for blur discrimination ranged from 0.28 to 0.56. It is concluded that the utility of blur variation as a depth cue is constrained by the relatively mediocre ability of observers to discriminate different levels of blur. Blur is best viewed as a relatively coarse, qualitative depth cue

Surfactant-free purification of membrane protein complexes from bacteria: application to the staphylococcal penicillin-binding protein complex PBP2/PBP2a

Surfactant-mediated removal of proteins from biomembranes invariably results in partial or complete loss of function and disassembly of multi-protein complexes. We determined the capacity of styrene-co-maleic acid (SMA) co-polymer to remove components of the cell division machinery from the membrane of drug-resistant staphylococcal cells. SMA-lipid nanoparticles solubilized FtsZ-PBP2-PBP2a complexes from intact cells, demonstrating the close physical proximity of these proteins within the lipid bilayer. Exposure of bacteria to (-)-epicatechin gallate, a polyphenolic agent that abolishes β-lactam resistance in staphylococci, disrupted the association between PBP2 and PBP2a. Thus, SMA purification provides a means to remove native integral membrane protein assemblages with minimal physical disruption and shows promise as a tool for the interrogation of molecular aspects of bacterial membrane protein structure and function

The prevalence of hepatitis C virus among people of South Asian origin in Glasgow: results from a community based survey and laboratory surveillance

Background South Asians often present late with HCV or HBV related liver disease which could have been avoided with early diagnosis and subsequent treatment; however the prevalence of HCV/HBV among South Asians in Glasgow is not known. Accordingly, to inform the need for case finding among this group we aimed to examine the prevalence of Hepatitis C virus (HCV) among South Asians living in Glasgow. Methods A community-based survey recruited individuals at six mosques and four community centres serving the South Asian community during 2009-2010; participants had predominantly never been HCV tested. Laboratory surveillance data involving all individuals tested for HCV during 1993-2009 were examined and South Asians were identified using Nam Pehchan software. Results In the community-based survey, 2.6% of 1288 participants tested HCV-antibody positive; the prevalence ranged from 0.6% among those born in the UK to 3.1% among those born in Pakistan. The odds of testing HCV-antibody positive were significantly raised among those who had surgery in South Asia (aOR: 5.0, 95% CI: 2.0-12.3) and had either medical/dental treatment or an injection in South Asia (aOR: 2.2, 95% CI: 1.0-5.0). Of 6404 South Asians identified from laboratory surveillance data, 9.3% tested HCV positive. An estimated 38% (330/870) of HCV-infected South Asians living in Glasgow remain undiagnosed. Conclusions South Asians living in Glasgow, particularly those born outside the UK are at greater risk of HCV infection than the general population. Efforts to increase awareness and testing in this population are warranted.</p

The microvascular endothelial glycocalyx:An additional piece of the puzzle in veterinary medicine

The endothelial glycocalyx (eGlx) is a critically important structure lining the luminal surface of endothelial cells. There is increasing evidence, in human patients and animal models, for its crucial role in the maintenance of health. Moreover, its damage is associated with the pathogenesis of multiple disease states. This review provides readers with an overview of the eGlx; summarising its structure, essential functions, and evidence for its role in disease. We highlight the lack of studies regarding the eGlx in cats and dogs, particularly in naturally occurring diseases. Importantly, we discuss techniques to aid its study, which can be applied to veterinary species. Finally, we present targeted therapies aimed at preserving, and in some cases, restoring damaged eGlx