Improving the external validity of clinical trials: the case of multiple chronic conditions

The U.S. Department of Health and Human Services vision and strategic framework on multiple chronic conditions (MCCs) incorporates recommendations designed to facilitate research that will improve our knowledge about interventions and systems that will benefit individuals with MCCs (or multimorbidity). The evidence base supporting the management of patients with MCCs will be built both through intervention trials specifically designed to address multimorbidity and identification of MCCs in participants across the clinical trial range. This article specifically focuses on issues relating to external validity with specific reference to trials involving patients with MCCs. The exclusion of such patients from clinical trials has been well documented. Randomized control trials (RCTs) are considered the “gold standard” of evidence, but may have drawbacks in relation to external validity, particularly in relation to multimorbidity. It may, therefore, be necessary to consider a broader range of research methods that can provide converging evidence on intervention effects to address MCCs. Approaches can also be taken to increase the usefulness of RCTs in general for providing evidence to inform multimorbidity management. Additional improvements to RCTs would include better reporting of inclusion and exclusion criteria and participant characteristics in relation to MCCs. New trials should be considered in terms of how they will add to the existing evidence base and should inform how interventions may work in different settings and patient groups. Research on treatments and interventions for patients with MCCs is badly needed. It is important that this research includes patient-centered measures and that generalizability issues be explicitly addressed.Journal of Comorbidity 2013;3(2)30–3

Collider Constraints on Dipole-Interacting Dark Matter

Dark matter which interacts through a magnetic or electric dipole moment is an interesting possibility which may help to resolve the discrepancy between the DAMA annual modulation signal and the null results of other searches. In this article we examine relic density and collider constraints on such dark matter, and find that for couplings needed to explain DAMA, the thermal relic density is generically in the right ballpark to account for cosmological measurements. Collider constraints are relevant for light WIMPs, but less constraining that direct searches for masses above about 10 GeV.Comment: 11 pages, 2 figures, extended discussion, added references, conclusion unchange

Occupational Gender Composition and Wages in Canada: 1987-1988

The relationship between occupational gender composition and wages is the basis of pay equity/comparable worth legislation. A number of previous studies have examined this relationship in US data, identifying some of the determinants of low wages in ``female jobs'' well as important limitations of public policy in this area. There is little evidence, however, from other jurisdictions. This omission is particularly disturbing in the case of Canada, which now has some of the most extensive pay equity legislation in the world. In this paper we provide a comprehensive picture, circa the late 1980's, of the occupational gender segregation in Canada and its consequences for wages. The sample period precedes many provincial pay equity initiatives and thus the results should provide a baseline for the evaluation of this legislation. We find that the estimated wage penalties in female jobs in Canada are generally much smaller than the estimates for the United States. Although there is some heterogeneity across worker groups on average, the link between female wages and gender composition is small and not statistically significant.

Rotating neutron stars with exotic cores: masses, radii, stability

A set of theoretical mass-radius relations for rigidly rotating neutron stars with exotic cores, obtained in various theories of dense matter, is reviewed. Two basic observational constraints are used: the largest measured rotation frequency (716 Hz) and the maximum measured mass ($2\;M_\odot$). Present status of measuring the radii of neutron stars is described. The theory of rigidly rotating stars in general relativity is reviewed and limitations of the slow rotation approximation are pointed out. Mass-radius relations for rotating neutron stars with hyperon and quark cores are illustrated using several models. Problems related to the non-uniqueness of the crust-core matching are mentioned. Limits on rigid rotation resulting from the mass-shedding instability and the instability with respect to the axisymmetric perturbations are summarized. The problem of instabilities and of the back-bending phenomenon are discussed in detail. Metastability and instability of a neutron star core in the case of a first-order phase transition, both between pure phases, and into a mixed-phase state, are reviewed. The case of two disjoint families (branches) of rotating neutron stars is discussed and generic features of neutron-star families and of core-quakes triggered by the instabilities are considered.Comment: Matches published version. Minor modifications and reference adde

VSAERO analysis of tip planforms for the free-tip rotor

The results of a numerical analysis of two interacting lifting surfaces separated in the spanwise direction by a narrow gap are presented. The configuration consists of a semispan wing with the last 32 percent of the span structurally separated from the inboard section. The angle of attack of the outboard section is set independently from that of the inboard section. In the present study, the three-dimensional panel code VSAERO is used to perform the analysis. Computed values of tip surface lift and pitching moment coefficients are correlated with experimental data to determine the proper approach to model the gap region between the surfaces. Pitching moment data for various tip planforms are also presented to show how the variation of tip pitching moment with angle of attack may be increased easily in incompressible flow. Calculated three-dimensional characteristics in compressible flow at Mach numbers of 0.5 and 0.7 are presented for new tip planform designs. An analysis of sectional aerodynamic center shift as a function of Mach number is also included for a representative tip planform. It is also shown that the induced drag of the tip surface is reduced for negative incidence angles relative to the inboard section. The results indicate that this local drag reduction overcomes the associated increase in wing induced drag at high wing lift coefficients

Evolution of quantum observables: from non-commutativity to commutativity

A fundamental aspect of the quantum-to-classical limit is the transition from a non- commutative algebra of observables to commutative one.However, this transition is not possible if we only consider unitary evolutions. One way to describe this transition is to consider the Gamow vectors, which introduce exponential decays in the evolution. In this paper, we give two mathematical models in which this transition happens in the infinite time limit. In the first one, we consider operators acting on the space of the Gamow vectors, which represent quantum resonances. In the second one, we use an algebraic formalism from scattering theory. We construct a non-commuting algebra which commutes in the infinite time limit.MINECO Grant MTM2014- 57129-C2-1-P. Junta de Castilla y Leon Grants BU229P18, VA137G18

L’impact des règles de prêts hypothécaires sur l’offre de travail des femmes au Canada : évidence paramétrique et non paramétrique

Cet article utilise des statistiques descriptives, des régressions flexibles de type noyau et des modèles à formes réduites pour montrer que des variables reliées aux conditions hypothécaires, en particulier une variable qui capture les exigences de revenu relatives aux prêts hypothécaires, ont un impact important sur l’offre de travail des femmes au Canada. Dans un modèle à formes réduites du nombre de semaines travaillées par l’épouse, l’impact positif de cette contrainte à l’emprunt excède l’effet négatif de la variable enfants d’âge préscolaire. Ce résultat ne peut être attribué à un problème d’endogénéité des variables hypothécaires. En effet, on ne peut rejeter l’exogénéité faible de la variable qui capture le test du revenu de la procédure d’accès au prêt hypothécaire, lorsqu’on utilise une procédure à deux étapes qui se sert des résidus généralisés pour effectuer un test de spécification à la Hausman.This paper use descriptive statistics, kernel regressions and reduced-form analyses to show that mortgage related variables, in particular a variable believed to capture the earnings test of mortgage lending rules, have an important impact on the labor supply of married women in Canada. In a reduced-form weeks-worked equation for wives, the positive impact of the earnings test is shown to exceed the negative effect of young children. This result cannot be attributed to the potential endogeneity of mortgage variables since it is not possible to reject the weak exogeneity of the earnings test using a two-stage procedure that relies on generalized residuals to perform a Hausman type specification test

Using Self-Adaptive Evolutionary Algorithms to Evolve Dynamism-Oriented Maps for a Real Time Strategy Game

9th International Conference on Large Scale Scientific Computations. The final publication is available at link.springer.comThis work presents a procedural content generation system that uses an evolutionary algorithm in order to generate interesting maps for a real-time strategy game, called Planet Wars. Interestingness is here captured by the dynamism of games (i.e., the extent to which they are action-packed). We consider two different approaches to measure the dynamism of the games resulting from these generated maps, one based on fluctuations in the resources controlled by either player and another one based on their confrontations. Both approaches rely on conducting several games on the map under scrutiny using top artificial intelligence (AI) bots for the game. Statistic gathered during these games are then transferred to a fuzzy system that determines the map's level of dynamism. We use an evolutionary algorithm featuring self-adaptation of mutation parameters and variable-length chromosomes (which means maps of different sizes) to produce increasingly dynamic maps.TIN2011-28627-C04-01, P10-TIC-608

Second-order critical lines of spin-S Ising models in a splitting field with Grassmann techniques

We propose a method to study the second-order critical lines of classical spin-$S$ Ising models on two-dimensional lattices in a crystal or splitting field, using an exact expression for the bare mass of the underlying field theory. Introducing a set of anticommuting variables to represent the partition function, we derive an exact and compact expression for the bare mass of the model including all local multi-fermions interactions. By extension of the Ising and Blume-Capel models, we extract the free energy singularities in the low momentum limit corresponding to a vanishing bare mass. The loci of these singularities define the critical lines depending on the spin S, in good agreement with previous numerical estimations. This scheme appears to be general enough to be applied in a variety of classical Hamiltonians