Bayesian predictions for A=6 nuclei using eigenvector continuation emulators

We make ab initio predictions for the A=6 nuclear level scheme based on two- and three-nucleon interactions up to next-to-next-to-leading order in chiral effective field theory (χEFT). We utilize eigenvector continuation and Bayesian methods to quantify uncertainties stemming from the many-body method, the χEFT truncation, and the low-energy constants of the nuclear interaction. The construction and validation of emulators is made possible via the development of jupiterncsm - a new M-scheme no-core shell model code that uses on-the-fly Hamiltonian matrix construction for efficient, single-node computations up to Nmax=10 for Li6. We find a slight underbinding of He6 and Li6, although consistent with experimental data given our theoretical error bars. As a result of incorporating correlated χEFT-truncation errors we find more precise predictions (smaller error bars) for separation energies: Sd(Li6)=0.89\ub10.44MeV, S2n(He6)=0.20\ub10.60MeV, and for the beta decay Q value: Qβ-(He6)=3.71\ub10.65MeV. We conclude that our error bars can potentially be reduced further by extending the model space used by jupiterncsm

Using horizontal sonic crystals to reduce the aeroacosutic signature of a simplified ICE3 train model

The design of noise barriers for high-speed trains is challenging due to the flow interaction between the train body and barriers. A failed design could affect the flow that in turn introduces additional aerodynamic loads to the train and generates extra noise. This study is the first investigation to numerically explore the detailed effects of noise barriers on high-speed trains. In particular, horizontal sonic crystals are compared to vertical, closed at the ground barriers in order to investigate the detailed effects of different noise screens on high-speed trains. The compressible IDDES is used to simulate the flow. The focus of this study is twofold. The first is to test if an alternative barrier typology can effectively reduce the noise signature, without having an impact on the train’s aerodynamic performance. The second is to explore the connection between the near-field velocity fluctuations and the far-field noise. A few specific tonal frequency components have been commonly reported but not clearly explained in the literature. It is unclear if the specific tonal components are less dependent on the Reynolds numbers, although, in general, energetic flow structures are dependent on inflow speeds. Concerning the noise reduction, the results show that the sonic crystal barrier case has a significantly better performance. A modal analysis is used to explore the causes of the tonal peaks and the association of the underbody swirling vortices to the far-field noise is described

Visualisation of traffic noise exposure and health impact in a 3D urban environment

It is becoming increasingly common to work with urban planning using 3D visualisation tools. In the project DemoVirPEN a research team with participation from different research fields cooperated to create a demonstration concept for visualising traffic noise and the associated health impact in a 3D graphics environment. The project included participation from the following fields; 3D modelling and mapping, traffic noise calculation, auralisation, urban planning and architecture and health impact of noise exposure. The final product of the project is summarised in a film clip that illustrates the main results by visualising and auralising traffic in different configurations from different perspectives. A few key points are visualising short time frames (single vehicle passage) versus yearly average (noise map), and impact of changes such as removing or modifying traffic flows and buildings

An urban planning tool demonstrator with auralisation and visualisation of the sound environment

The paper presents findings from a recent project about the development of a demonstrator of an urban planning tool that includes auralised sounds as well as visualisations of sound propagation and facade noise levels linked to health impact. In urban development projects, the sound environment is one of the key elements, but often enters late in the planning process. As a result, even if the noise regulations are fulfilled, the potentially good sound environment may suffer unnecessary quality reductions. In addition, the standard ways of presenting and analysing the situations, using noise levels and noise maps, has potential for improvement, especially considering the transdisciplinary approaches to planning that are increasing in use. The tool aims to simplify the usage also at early stage planning, including scenario analysis, as well as to facilitate the urban planners\u27 understanding of the sound environment and its effects. The paper presents results from the development of the demonstrator, reflecting on auralisation as well as on multiple aspects of visualisation including grid noise maps, health-related facade noise levels and choice of colour scales

Neurofilament light chain as a potential biomarker for monitoring neurodegeneration in X-linked adrenoleukodystrophy

X-linked adrenoleukodystrophy (X-ALD), the most frequent monogenetic disorder of brain white matter, is highly variable, ranging from slowly progressive adrenomyeloneuropathy (AMN) to life-threatening inflammatory brain demyelination (CALD). In this study involving 94 X-ALD patients and 55 controls, we tested whether plasma/serum neurofilament light chain protein (NfL) constitutes an early distinguishing biomarker. In AMN, we found moderately elevated NfL with increased levels reflecting higher grading of myelopathy-related disability. Intriguingly, NfL was a significant predictor to discriminate non-converting AMN from cohorts later developing CALD. In CALD, markedly amplified NfL levels reflected brain lesion severity. In rare cases, atypically low NfL revealed a previously unrecognized smoldering CALD disease course with slowly progressive myelin destruction. Upon halt of brain demyelination by hematopoietic stem cell transplantation, NfL gradually normalized. Together, our study reveals that blood NfL reflects inflammatory activity and progression in CALD patients, thus constituting a potential surrogate biomarker that may facilitate clinical decisions and therapeutic development