Short-Term Very High Carbohydrate Diet and Gut-Training Have Minor Effects on Gastrointestinal Status and Performance in Highly Trained Endurance Athletes

We implemented a multi-pronged strategy (MAX) involving chronic (2 weeks high carbohydrate [CHO] diet + gut-training) and acute (CHO loading + 90 g·h(−1) CHO during exercise) strategies to promote endogenous and exogenous CHO availability, compared with strategies reflecting lower ranges of current guidelines (CON) in two groups of athletes. Nineteen elite male race walkers (MAX: 9; CON:10) undertook a 26 km race-walking session before and after the respective interventions to investigate gastrointestinal function (absorption capacity), integrity (epithelial injury), and symptoms (GIS). We observed considerable individual variability in responses, resulting in a statistically significant (p < 0.001) yet likely clinically insignificant increase (Δ 736 pg·mL(−1)) in I-FABP after exercise across all trials, with no significant differences in breath H(2) across exercise (p = 0.970). MAX was associated with increased GIS in the second half of the exercise, especially in upper GIS (p < 0.01). Eighteen highly trained male and female distance runners (MAX: 10; CON: 8) then completed a 35 km run (28 km steady-state + 7 km time-trial) supported by either a slightly modified MAX or CON strategy. Inter-individual variability was observed, without major differences in epithelial cell intestinal fatty acid binding protein (I-FABP) or GIS, due to exercise, trial, or group, despite the 3-fold increase in exercise CHO intake in MAX post-intervention. The tight-junction (claudin-3) response decreased in both groups from pre- to post-intervention. Groups achieved a similar performance improvement from pre- to post-intervention (CON = 39 s [95 CI 15–63 s]; MAX = 36 s [13–59 s]; p = 0.002). Although this suggests that further increases in CHO availability above current guidelines do not confer additional advantages, limitations in our study execution (e.g., confounding loss of BM in several individuals despite a live-in training camp environment and significant increases in aerobic capacity due to intensified training) may have masked small differences. Therefore, athletes should meet the minimum CHO guidelines for training and competition goals, noting that, with practice, increased CHO intake can be tolerated, and may contribute to performance outcomes

Outpatient parenteral antibiotic therapy (OPAT): a qualitative study of patient perspectives in those choosing not to self-administer.

OPAT is a well established treatment for administration of intravenous (IV) antibiotics, and models of administration include home self-administration. Despite this offering advantages, statistics indicate that less patients in the research centre home self-administer compared with other national centres

Short-term very high carbohydrate diet and gut-training have minor effects on gastrointestinal status and performance in highly trained endurance athletes

We implemented a multi-pronged strategy (MAX) involving chronic (2 weeks high carbohydrate [CHO] diet + gut-training) and acute (CHO loading + 90 g·h−1 CHO during exercise) strategies to promote endogenous and exogenous CHO availability, compared with strategies reflecting lower ranges of current guidelines (CON) in two groups of athletes. Nineteen elite male race walkers (MAX: 9; CON:10) undertook a 26 km race-walking session before and after the respective interventions to investigate gastrointestinal function (absorption capacity), integrity (epithelial injury), and symptoms (GIS). We observed considerable individual variability in responses, resulting in a statistically significant (p < 0.001) yet likely clinically insignificant increase (Δ 736 pg·mL−1) in I-FABP after exercise across all trials, with no significant differences in breath H2 across exercise (p = 0.970). MAX was associated with increased GIS in the second half of the exercise, especially in upper GIS (p < 0.01). Eighteen highly trained male and female distance runners (MAX: 10; CON: 8) then completed a 35 km run (28 km steady-state + 7 km time-trial) supported by either a slightly modified MAX or CON strategy. Inter-individual variability was observed, without major differences in epithelial cell intestinal fatty acid binding protein (I-FABP) or GIS, due to exercise, trial, or group, despite the 3-fold increase in exercise CHO intake in MAX post-intervention. The tight-junction (claudin-3) response decreased in both groups from pre- to post-intervention. Groups achieved a similar performance improvement from pre- to post-intervention (CON = 39 s [95 CI 15–63 s]; MAX = 36 s [13–59 s]; p = 0.002). Although this suggests that further increases in CHO availability above current guidelines do not confer additional advantages, limitations in our study execution (e.g., confounding loss of BM in several individuals despite a live-in training camp environment and significant increases in aerobic capacity due to intensified training) may have masked small differences. Therefore, athletes should meet the minimum CHO guidelines for training and competition goals, noting that, with practice, increased CHO intake can be tolerated, and may contribute to performance outcomes

Few-body physics with ultracold atomic and molecular systems in traps

Few-body physics has played a prominent role in atomic, molecular and nuclear physics since the early days of quantum mechanics. It is now possible---thanks to tremendous progress in cooling, trapping, and manipulating ultracold samples---to experimentally study few-body phenomena in trapped atomic and molecular systems with unprecedented control. This review summarizes recent studies of few-body phenomena in trapped atomic and molecular gases, with an emphasis on small trapped systems. We start by introducing the free-space scattering properties and then investigate what happens when two particles, bosons or fermions, are placed in an external confinement. Next, various three-body systems are treated analytically in limiting cases. Our current understanding of larger two-component Fermi systems and Bose systems is reviewed, and connections with the corresponding bulk systems are established. Lastly, future prospects and challenges are discussed. Throughout this review, commonalities with other systems such as nuclei or quantum dots are highlighted.Comment: review article to be published in Rep. Prog. Phys. (66 pages, 21 figures

Local Group(s)

The properties of the galaxies of the Local Group are reviewed, followed by a brief discussion of nearby groups. The galaxy groups in our vicinity - the M81 group, the Cen A group, and the IC 342/Maffei group - are in many respects Local Group analogs: Their luminosity functions, galaxy content, fractional galaxy type distribution, crossing times, masses, and zero-velocity surface radii are similar to those of the Local Group. Also, the nearby groups usually consist of two subgroups, some of which approach each other and may ultimately merge to form a fossil group. These poor groups contrast with the less evolved, loose and extended galaxy ``clouds'' such as the Scl group and the CVn I cloud. These are characterized by long crossing times, are dominated by gas-rich, late-type galaxies, and lack gas-deficient, low luminosity early-type dwarfs. These clouds may be groups still in formation. The local Hubble flow derived from the clouds and groups is very cold.Comment: 17 pages, no figures. Invited review to appear in the proceedings of the ESO workshop "Groups of Galaxies in the Nearby Universe", Santiago, Dec 5-9, 2005. Eds. I. Saviane, V. Ivanov, & J. Borissova (Springer Verlag

Charting the decline in spontaneous writing in Alzheimer's disease: A longitudinal study

Objective: This study aims to document the nature and progression of the spontaneous writing impairment observed in patients with Alzheimer's disease (AD) over a 12-month period using both a cross-sectional and prospective longitudinal design.Methods: Thirty-one minimal-moderate AD patients and 30 controls matched for age and socio-cultural background completed a simple and complex written description task at baseline. The AD patients then had follow-up assessments at 6 and 12 months.Results: Cross-sectional comparisons indicated that minimal-moderate AD patients produced more semantic paraphasias, phonological paraphasias, and empty and indefinite phrases, whilst producing fewer pictorial themes, repairing fewer errors, and producing shorter and less complex sentences than controls. The two groups could not be distinguished on visual paraphasias. Longitudinal follow-up, however, suggested that visual processing deteriorates over time, where the prevalence of visual errors increased over 12 months.Discussion: The findings suggest that the deterioration of writing skills observed in the spontaneous writings of AD patients shows a pattern of impairment dominated by semantic errors with a secondary impairment in phonological processing, which is later joined by a disruption of visuospatial and graphomotor processing