Pharmaceutical Formulation Facilities as Sources of Opioids and Other Pharmaceuticals to Wastewater Treatment Plant Effluents

Facilities involved in the manufacture of pharmaceutical products are an under-investigated source of pharmaceuticals to the environment. Between 2004 and 2009, 35 to 38 effluent samples were collected from each of three wastewater treatment plants (WWTPs) in New York and analyzed for seven pharmaceuticals including opioids and muscle relaxants. Two WWTPs (NY2 and NY3) receive substantial flows (>20% of plant flow) from pharmaceutical formulation facilities (PFF) and one (NY1) receives no PFF flow. Samples of effluents from 23 WWTPs across the United States were analyzed once for these pharmaceuticals as part of a national survey. Maximum pharmaceutical effluent concentrations for the national survey and NY1 effluent samples were generally <1 μg/L. Four pharmaceuticals (methadone, oxycodone, butalbital, and metaxalone) in samples of NY3 effluent had median concentrations ranging from 3.4 to >400 μg/L. Maximum concentrations of oxycodone (1700 μg/L) and metaxalone (3800 μg/L) in samples from NY3 effluent exceeded 1000 μg/L. Three pharmaceuticals (butalbital, carisoprodol, and oxycodone) in samples of NY2 effluent had median concentrations ranging from 2 to 11 μg/L. These findings suggest that current manufacturing practices at these PFFs can result in pharmaceuticals concentrations from 10 to 1000 times higher than those typically found in WWTP effluents

Glycaemic control and hypoglycaemia with insulin glargine 300U/mL versus insulin glargine 100U/mL in insulin-<em>na\uefve</em> people with type 2 diabetes: 12-month results from the EDITION 3 trial

Aerodynamic drag is the cause for more than two-thirds of the fuel consumption of large trucks at highway speeds. Due to functionality considerations, the aerodynamic efficiency of the aft-regions of large trucks was traditionally sacrificed. This leads to massively separated flow at the lee-side of truck-trailers, with an associated drag penalty of at least a third of the total aerodynamic drag. Active Flow Control (AFC), the capability to alter the flow behavior using unsteady, localized energy injection, can very effectively delay boundary layer separation. By attaching a compact and relatively inexpensive “add-on” AFC device to the back side of truck-trailers (or by modifying it when possible) the flow separating from it could be redirected to turn into the lee-side of the truck, increasing the back pressure, thus significantly reducing drag. A comprehensive and aggressive research plan that combines actuator development, computational fluid dynamics and bench-top as well as wind tunnel experiments was performed. The research uses an array of 15 newly developed Suction and Oscillatory Blowing actuators housed inside a circular cylinder attached to the aft edges of a generic 2D truck model. Preliminary results indicate a net drag reduction of 10% or more

GroupBanter: Supporting Serendipitous Group Conversations with IM

Abstract. This paper describes GroupBanter, a tool for supporting serendipitous group conversations using instant messaging. We investigate the potential of ephemeral group conversations by providing awareness of friends‟ IM conversations, serving as an implicit invitation to join a group conversation. We present our vision and describe our prototype system. Results from two field studies carried out in different contexts show that users valued GroupBanter and that it provided new opportunities for communication that aren‟t well served by traditional IM, email, or face-to-face communication. Our results indicate there is potential in providing a lightweight communication channel that lies between traditional, private IM conversations and more public IRC-like conversations