Split Fermi seas in one-dimensional Bose fluids

For the one-dimensional repulsive Bose gas (Lieb-Liniger model), we study a special class of highly-excited states obtained by giving a finite momentum to subgroups of particles. These states, which correspond to `splitting' the ground state Fermi sea-like quantum number configuration, are zero-entropy states which display interesting properties more normally associated to ground states. Using a numerically exact method based on integrability, we study these states' excitation spectrum, density correlations and momentum distribution functions. These correlations display power-law asymptotics, and are shown to be accurately described by an effective multicomponent Tomonaga-Luttinger liquid theory whose parameters are obtained from Bethe Ansatz. The non-universal correlation prefactors are moreover obtained from integrability, yielding a completely parameter-free fit of the correlator asymptotics.Comment: 10 pages, 14 figure

Big Cities, Big Problems? Reason for the Elderly to Move?

In many European countries, data on geographical patterns of internal elderly migration show that the elderly (55+) are more likely to leave than to move to the big cities. Besides emphasising the attractive features of the destination areas (pull factors), it is often assumed that this negative balance of migration of elderly people is caused by problems which mainly the big cities have to contend with and which would have a negative effect on living conditions, especially of the elderly (push factors). Although it is well-known that big cities in Europe are faced with several specific housing and neighbourhood problems, no detailed research has been carried out so far into whether these problems are indeed seen by the elderly themselves as very negative and, if so, whether these perceived problems result in an intention to move as a result of housing and neighbourhood dissatisfaction. The aim of this article is to shed empirical light on this matter for a case study in the Netherlands

A prolonged methoxymorpholino doxorubicin (PNU-152243 or MMRDX) infusion schedule in patients with solid tumours: a phase 1 and pharmacokinetic study

The aim of this phase I study was to assess feasibility, pharmacokinetics and toxicity of methoxymorpholino doxorubicin (MMRDX or PNU-152243) administered as a 3 h intravenous infusion once every 4 weeks. Fourteen patients with intrinsically anthracycline-resistant tumours received 37 cycles of MMRDX. The first cohort of patients was treated with 1 mg m−2of MMRDX. The next cohorts received 1.25 mg m−2and 1.5 mg m−2respectively. Common toxicity criteria (CTC) grade III/IV nausea and vomiting were observed in 1/18 cycles at 1.25 mg m−2and in 2/11 cycles at 1.5 mg m−2. Transient elevation in transaminases up to CTC grade III was observed in 2/16 cycles at 1.25 mg m−2and 4/11 cycles at 1.5 mg m−2. No cardiotoxicity was observed. At 1.25 mg m−2CTC grade IV neutropenia occurred in 1/17 cycles. At 1.5 mg m−2CTC grade III neutropenia was seen in 2/7 and grade IV in 3/7 evaluable cycles. Thrombocytopenia grade III was observed in 2/9 and grade IV in 1/9 evaluable cycles. One patient treated at 1.5 mg m−2died with neutropenic fever. Therefore, dose-limiting toxicity was reached and 1.25 mg m−2was considered the maximum tolerated dose for MMRDX as 3 h infusion. No tumour responses were observed. Pharmacokinetic parameters showed a rapid clearance of MMRDX from the circulation by an extensive tissue distribution. Renal excretion of the drug and its metabolite was negligible. In conclusion, prolongation of MMRDX infusion to 3 h does not improve the toxicity profile as compared with bolus administration. © 2000 Cancer Research Campaig

Comparing generations of migrants’ transnational behaviour: the role of the transnational convoy and integration

This paper compares generations (G1, G1.5, G2, G3) of male Turkish migrants to Europe in their transnational behaviours: contact frequency, visits, remittances, property ownership and voting. We aim to explain differences by generational differences in transnational convoy size and integration into residence countries. Data from 798 members of migrant families were obtained from 2000 Families. Generations differ in visiting, remitting, property ownership and voting, but not in contact frequency. Using regression analysis, the transnational convoy cannot explain transnational behaviours. Structural and socio-cultural integration impact various transnational behaviours within generations. Generally, waning of transnational ties across generations cannot be attributed to differences in transnational ties or integration. We add to knowledge on generational differences in transnational behaviour until the third generation and on determinants of transnational behaviour, but conclude that the field of transnational studies is in need of further refinement of operationalization and theory to understand generational differences in transnational behaviour

Platinum-(IV)-derivative satraplatin induced G2/M cell cycle perturbation via p53-p21(waf1/cip1)-independent pathway in human colorectal cancer cells

Platinum-(IV)-derivative satraplatin represents a new generation of orally available anti-cancer drugs that are under development for the treatment of several cancers. Understanding the mechanisms of cell cycle modulation and apoptosis is necessary to define the mode of action of satraplatin. In this study, we investigate the ability of satraplatin to induce cell cycle perturbation, clonogenicity loss and apoptosis in colorectal cancer (CRC) cells.Platinum-(IV)-derivative satraplatin represents a new generation of orally available anti-cancer drugs that are under development for the treatment of several cancers. Understanding the mechanisms of cell cycle modulation and apoptosis is necessary to define the mode of action of satraplatin. In this study, we investigate the ability of satraplatin to induce cell cycle perturbation, clonogenicity loss and apoptosis in colorectal cancer (CRC) cells

Towards Next-Generation Sequencing (NGS)-Based Newborn Screening:A Technical Study to Prepare for the Challenges Ahead

Newborn screening (NBS) aims to identify neonates with severe conditions for whom immediate treatment is required. Currently, a biochemistry-first approach is used to identify these disorders, which are predominantly inherited metalbolic disorders (IMD). Next-generation sequencing (NGS) is expected to have some advantages over the current approach, for example the ability to detect IMDs that meet all screening criteria but lack an identifiable biochemical footprint. We have now designed a technical study to explore the use of NGS techniques as a first-tier approach in NBS. Here, we describe the aim and set-up of the NGS-first for the NBS (NGSf4NBS) project, which will proceed in three steps. In Step 1, we will identify IMDs eligible for NGS-first testing, based on treatability. In Step 2, we will investigate the feasibility, limitations and comparability of different technical NGS approaches and analysis workflows for NBS, eventually aiming to develop a rapid NGS-based workflow. Finally, in Step 3, we will prepare for the incorporation of this workflow into the existing Dutch NBS program and propose a protocol for referral of a child after a positive NGS test result. The results of this study will be the basis for an additional analytical route within NBS that will be further studied for its applicability within the NBS program, e.g., regarding the ethical, legal, financial and social implications.</p