Global range of human skin pigmentation assessed by the melanin index (MI).

<p>Global range of human skin pigmentation assessed by the melanin index (MI).</p

The structure of the human <i>SLC24A5</i> gene (Chromosome 15q21.1, 48409019 to 48434692).

<p>Exons of the gene are shown in yellow, introns in blue and 5′ flanking region in pink. The black lines underneath the gene show the regions resequenced in this study (total of 11741 bp) spanning 25674 bp. rs1426654 is the functional SNP located in the third exon.</p

Association of rs1426654 genotypes with melanin index.

<p>(A) Distribution of melanin index (MI) in 1228 individuals of Cohort A. The two dotted black lines represent approximately 10% thresholds for the low (MI<38) and high (MI>50) MI groups, which were used to assess genotype-phenotype association using a logistic regression model. (B) Distribution of mean melanin index for the genotypes of rs1426654. The mean melanin indices for each genotype, as obtained separetely for males and females are shown together with their 95% confidence intervals, as estimated by multiple imputation model (<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003912#pgen.1003912.s008" target="_blank">Table S3A</a>).</p

Heat map showing the intra- and inter-population variation measured by average pairwise sequence differences of the <i>SLC24A5</i> gene.

<p>The upper triangle of the matrix (green) shows average pairwise differences between populations (PiXY). The average number of pairwise differences (PiX) within each population is shown along the diagonal (orange). The lower triangle of the matrix (blue) shows differences between populations based on Nei's distance, i.e., corrected average pairwise differences (PiXY−(PiX+PiY)/2).</p