Outcomes of conjunctival compression sutures for hypotony after glaucoma filtering surgery

3openopenQuaranta L.; Riva I.; Floriani I.C:Quaranta, Luciano; Riva, Ivano; Floriani I., C

Computing multiparameter persistent homology through a discrete Morse-based approach

Persistent homology allows for tracking topological features, like loops, holes and their higher-dimensional analogues, along a single-parameter family of nested shapes. Computing descriptors for complex data characterized by multiple parameters is becoming a major challenging task in several applications, including physics, chemistry, medicine, and geography. Multiparameter persistent homology generalizes persistent homology to allow for the exploration and analysis of shapes endowed with multiple filtering functions. Still, computational constraints prevent multiparameter persistent homology to be a feasible tool for analyzing large size data sets. We consider discrete Morse theory as a strategy to reduce the computation of multiparameter persistent homology by working on a reduced dataset. We propose a new preprocessing algorithm, well suited for parallel and distributed implementations, and we provide the first evaluation of the impact of multiparameter persistent homology on computations

Effects of the timolol-dorzolamide fixed combination and latanoprost on circadian diastolic ocular perfusion pressure in glaucoma.

PURPOSE. To evaluate the effect of the timolol-dorzolamide fixed combination (TDFC) and latanoprost 0.005% on 24-hour intraocular pressure (IOP), systolic (SBP) and diastolic (DBP) blood pressure, and diastolic ocular perfusion pressure (DOPP) in patients with primary open-angle glaucoma (POAG). METHODS. This was an institutional, randomized clinical trial. After a 24-hour assessment without treatment, 27 previously untreated patients with POAG were randomized to 6 weeks’ treatment with twice-daily TDFC (8 AM and 8 PM) followed by once-daily latanoprost 0.005% (8 PM), or vice versa. One eye was analyzed per patient. The mean values of IOP, DBP, SBP, and DOPP (difference between DBP and IOP) were recorded at each time point, and the 24-hour data are the mean values of each patient’s measurements over the 24-hour period. The differences between the values of the first treatment period and the baseline and the second treatment period and washout were calculated and analyzed by means of an analysis of variance model that tested the effects of sequence and treatment. RESULTS. Both treatments significantly reduced 24-hour IOP (P <0.0001), but TDFC led to lower 24-hour pressure (mean ±SD: 15.4 ±1.9 vs. 16.7± 1.7 mm Hg; P=0.004). Latanoprost did not lead to any significant reduction in mean 24-hour SBP and DBP (SBP: P =0.952; DBP: P=0.831), but TDFC did (SBP and DBP: P < 0.0001). Both treatments significantly increased 24-hour DOPP (P < 0.0001), with no difference between the two medications (P=0.09). CONCLUSIONS. In previously untreated patients with POAG, TDFC, and latanoprost equally enhanced 24-hour DOPP: the former by counteracting the decrease in DBP with a substantial reduction in IOP and the latter by not affecting DBP and significantly reducing IO

Representing Terrain With Mathematical Operators

This work describes a mathematical representation of terrain data consisting of a novel operation, the “drill”. It facilitates the representation of legal terrains, capturing the richness of the physics of the terrain’s generation by digging channels in the surface. Given our current reliance on digital map data, hand-held devices, and GPS navigation systems, the accuracy and compactness of terrain data representations are becoming increasingly important. Representing a terrain as a series of operations that can procedurally regenerate the terrains allows for compact representation that retains more information than height fields, TINs, and other popular representations. Our model relies on the hydrography information extracted from the terrain, and so drainage information is retained during encoding. To determine the shape of the drill along each channel in the channel network, a cross section of the channel is extracted, and a quadratic polynomial is fit to it. We extract the drill representation from a mountainous dataset, using a series of parameters (including size and area of influence of the drill, as well as the density of the hydrography data), and present the accuracy calculated using a series of metrics. We demonstrate that the drill operator provides a viable and accurate terrain representation that captures both the terrain shape and the richness of its generation

Efficacy and safety of trabeculectomy vs nonpenetrating surgical procedures: a systematic review and meta-analysis

To date, only a few studies have directly compared nonpenetrating surgery (NPS) and trabeculectomy (TE). Therefore, there is no strong evidence as to which surgical technique leads to the best results in terms of ocular hypotensive effect and safety

Twenty-four hour efficacy with preservative free tafluprost compared with latanoprost in patients with primary open angle glaucoma or ocular hypertension

10openopenKonstas A.G.; Quaranta L.; Katsanos A.; Riva I.; Tsai J.C.; Giannopoulos T.; Voudouragkaki I.C.; Paschalinou E.; Floriani I.; Haidich A.B.Konstas, A. G.; Quaranta, Luciano; Katsanos, A.; Riva, Ivano; Tsai, J. C.; Giannopoulos, T.; Voudouragkaki, I. C.; Paschalinou, E.; Floriani, I.; Haidich, A. B