Modular Terpenoid Construction via Catalytic Enantioselective Formation of All-Carbon Quaternary Centers: Total Synthesis of Oridamycin A, Triptoquinones B and C, and Isoiresin

Total syntheses of orida­mycin A, tripto­quinones B and C, and iso­iresin are accomplished from a common intermediate prepared via iridium-catalyzed alcohol C–H <i>tert</i>-(hydroxy)­prenylation - a byproduct-free process that forms an all-carbon quaternary stereocenter with excellent control of diastereo- and enantio­selectivity