Additional file 1: of Evaluation in alcohol use disorders – insights from the nalmefene experience

References. (XLSX 58 kb

Flow diagram.

<p>FDA, US Food and Drug Administration.</p

Key principles, participant dialogue, and research and policy implications when assessing scientists.

<p>Key principles, participant dialogue, and research and policy implications when assessing scientists.</p

A list of sources examining the problems, potential unanticipated consequences, proposed solutions, and potential limitations when assessing science and scientists.

<p>A list of sources examining the problems, potential unanticipated consequences, proposed solutions, and potential limitations when assessing science and scientists.</p

Summary of the analysis of correlations between verbal fluency (animals) and glucose metabolism.

<p>(<i>p</i><0.001, uncorrected, <i>k</i>>50) in 15 OCD patients. Increases in neuropsychological data are correlated with increases in glucose metabolism. (BA: Brodman area).</p

Initial characteristics and neuropsychological performances of OCD patients and healthy controls.

<p>RCFT: Rey-Osterrieth Complex Figure Test.</p><p>TMT: Trail Making Test.</p><p>OAT: Object Alternation Task.</p><p>NA: Not applicable (either because no measure was available for healthy controls or because patients and controls were matched for these variables).</p

Significantly decreased metabolic activity in the OCD patient group compared with healthy volunteers in the right cingulate gyrus (BA 31) (<i>p</i><0.001 uncorrected, colour bar represents <i>t</i> values).

<p>Sagittal and coronal views in projection onto brain slices of a standard MRI (x/y/z coordinates according to Talairach atlas).</p

Comparison of regional glucose metabolism between OCD patients and healthy volunteers.

<p>(<i>p</i><0.001, uncorrected, <i>k</i>>50) (BA: Brodman area).</p

Summary of the analysis of correlations between verbal fluency (animals) and glucose metabolism (<i>p</i><0.001, uncorrected, <i>k</i>>50) in 15 OCD patients.

<p>Increases in neuropsychological data are correlated with decreases in glucose metabolism. (BA: Brodman area).</p

Summary of the analysis of correlations between Tower of London completion times and glucose metabolism (<i>p</i><0.001, uncorrected, <i>k</i>>50) in 15 OCD patients.

<p>Increases in neuropsychological data are correlated with increases in glucose metabolism. (BA: Brodman area).</p