Variables of disease course and their correlation with EDSS outcome 10 years after disease onset

<p>Variables of disease course and their correlation with EDSS outcome 10 years after disease onset</p

time to cognitive dysfunction.

<p>Kaplan-Meier curves of the risk of developing cognitive dysfunction according to disability status 10 years after onset. Log rank test used for calculation of significancy.</p

NMDAR IgG antibody titers and ΔMFI values in the validation group.

<p>(A) With the CBA all sera of NMDAR encephalitis patients were positive for NMDAR IgG antibodies, but none of the neurological controls. (B) Using the FACS assay serum NMDAR IgG ΔMFI levels were higher in patients with NMDAR encephalitis than in neurological controls, but again two sera positive for NMDAR antibodies were missed with this method (shown in red). The cut-off ΔMFI value of 20,700 as determined in the discovery group is indicated by a dashed horizontal line. Antibody titers and ΔMFI values were compared using a non-parametric test (Mann-Whitney <i>U</i> test) and overall p-values are shown in the graphs. Medians are indicated by horizontal bars. CBA = cell-based assay. ΔMFI = delta median fluorescence intensity. FACS = fluorescence activated cell sorting. NC = neurological controls. NMDAR-E = <i>N</i>-methyl-D-aspartate receptor encephalitis.</p

Percentages of CD3+ T cells (A), CD19+CD138− mature B cells (B) and CD19+CD138+ plasma blasts (C) in the CSF of patients with a CIS, RRMS, CPMS and OND.

<p>Individual data points are shown as circles and horizontal bars indicate means. Data were compared using the Kruskal-Wallis test and Dunn's multiple comparison post-hoc test and overall p-values are shown in each figure. # = significant differences to the OND group.</p