Change in the Mankin Scale score after MIA (blue) or Col-2 (red) injection as a function of time.

Change in the Mankin Scale score after MIA (blue) or Col-2 (red) injection as a function of time.</p

Change in the HWT of TMJs with/without MIA injection as a function of time.

*Significant values.</p

Examples of histological slides after toluidine blue staining.

A: sample (before injection of MIA or Col-2) without histological and staining modification; B: sample (day 30 Col-2) with a pannus, hypocellularity, and moderate staining reduction; C: sample (day 30 MIA) with hypocellularity, clefts, and severe reduction of proteoglycan staining.</p

Change in the FDG level after MIA (blue) or Col-2 (red) injection as a function of time.

Change in the FDG level after MIA (blue) or Col-2 (red) injection as a function of time.</p

Comparison between signals at TMJs and periarticular muscles in a non-injected rat (left, SUV score = 1.02) and an MIA-injected rat (right, SUV score = 1.91) at day 14.

Comparison between signals at TMJs and periarticular muscles in a non-injected rat (left, SUV score = 1.02) and an MIA-injected rat (right, SUV score = 1.91) at day 14.</p

Entire TMJ sample with description.

Entire TMJ sample with description.</p

Study protocol.

Study protocol.</p

Change in the HWT of TMJs with/without Col-2 injection as a function of time.

*Significant values.</p

Change in the HWT after MIA (blue) or Col-2 (red) injection as a function of time.

Values are the mean ± SD and were analyzed using the Mann–Whitney test. *Significant values.</p