Theodor Fliedner [Saksa pastor] : Diakonissa-töö uuendaja

Digiteeritud Euroopa Regionaalarengu Fondi rahastusel, projekti "Eesti teadus- ja õppekirjandus" (2014-2020.12.03.21-0848) raames.https://www.ester.ee/record=b1219874*es

HEMOPOIETIC RESPONSE TO LOW DOSE-RATES OF IONIZING RADIATION SHOWS STEM CELL TOLERANCE AND ADAPTATION

Chronic exposure of mammals to low dose-rates of ionizing radiation affects proliferating cell systems as a function of both dose-rate and the total dose accumulated. The lower the dose-rate the higher needs to be the total dose for a deterministic effect, i.e., tissue reaction to appear. Stem cells provide for proliferating, maturing and functional cells. Stem cells usually are particularly radiosensitive and damage to them may propagate to cause failure of functional cells. The paper revisits 1) medical histories with emphasis on the hemopoietic system of the victims of ten accidental chronic radiation exposures, 2) published hematological findings of long-term chronically gamma-irradiated rodents, and 3) such findings in dogs chronically exposed in large life-span studies. The data are consistent with the hypothesis that hemopoietic stem and early progenitor cells have the capacity to tolerate and adapt to being repetitively hit by energy deposition events. The data are compatible with the “injured stem cell hypothesis”, stating that radiation–injured stem cells, depending on dose-rate, may continue to deliver clones of functional cells that maintain homeostasis of hemopoiesis throughout life. Further studies perhaps on separated hemopoietic stem cells may unravel the molecular-biology mechanisms causing radiation tolerance and adaptation

Responses of Cell Renewal Systems to Long-term Low-Level Radiation Exposure: A Feasibility Study Applying Advanced Molecular Biology Techniques on Available Histological and Cytological Material of Exposed Animals and Men

First results of this feasibility study showed that evaluation of the stored material of the chronically irradiated dogs with modern molecular biological techniques proved to be successful and extremely promising. Therefore an in deep analysis of at least part of the huge amount of remaining material is of outmost interest. The methods applied in this feasibility study were pathological evaluation with different staining methods, protein analysis by means of immunohistochemistry, strand break analysis with the TdT-assay, DNA- and RNA-analysis as well as genomic examination by gene array. Overall more than 50% of the investigated material could be used. In particular the results of an increased stimulation of the immune system within the dogs of the 3mSv group as both compared to the control and higher dose groups gives implications for the in depth study of the cellular events occurring in context with low dose radiation. Based on the findings of this study a further evaluation and statistically analysis of more material can help to identify promising biomarkers for low dose radiation. A systematic evaluation of a correlation of dose rates and strand breaks within the dog tissue might moreover help to explain mechanisms of tolerance to IR. One central problem is that most sequences for dog specific primers are not known yet. The discovery of the dog genome is still under progress. In this study the isolation of RNA within the dog tissue was successful. But up to now there are no gene arrays or gene chips commercially available, tested and adapted for canine tissue. The uncritical use of untested genomic test systems for canine tissue seems to be ineffective at the moment, time consuming and ineffective. Next steps in the investigation of genomic changes after IR within the stored dog tissue should be limited to quantitative RT-PCR of tested primer sequences for the dog. A collaboration with institutions working in the field of the discovery of the dog genome could have synergistic effects

Reisen in das heilige Land, nach Smyrna, Beirut, Constantinopel, Alexandrien und Cairo, in den Jahren 1851, 1856 und 1857 : In zwei Theilen / von Theodor Fliedner, Dr. der Theologie, Pfarrer und Inspektor der Diakonissen-Anstalt zu Kaiserswerth

REISEN IN DAS HEILIGE LAND, NACH SMYRNA, BEIRUT, CONSTANTINOPEL, ALEXANDRIEN UND CAIRO, IN DEN JAHREN 1851, 1856 UND 1857 : IN ZWEI THEILEN / VON THEODOR FLIEDNER, DR. DER THEOLOGIE, PFARRER UND INSPEKTOR DER DIAKONISSEN-ANSTALT ZU KAISERSWERTH Reisen in das heilige Land, nach Smyrna, Beirut, Constantinopel, Alexandrien und Cairo, in den Jahren 1851, 1856 und 1857 : In zwei Theilen / von Theodor Fliedner, Dr. der Theologie, Pfarrer und Inspektor der Diakonissen-Anstalt zu Kaiserswerth Reise mit 4 Diakonissen in das h. Land, nach Smyrna, Beirut und Constantinopel im Jahre 1851 : Mit 71 Abbildungen, einem Plane von Jerusalem und einer Charte von Palästina und einem Theile Aegyptens. (Theil 1

Reise mit 4 Diakonissen in das h. Land, nach Smyrna, Beirut und Constantinopel im Jahre 1851 : Mit 71 Abbildungen, einem Plane von Jerusalem und einer Charte von Palästina und einem Theile Aegyptens.

REISE MIT 4 DIAKONISSEN IN DAS H. LAND, NACH SMYRNA, BEIRUT UND CONSTANTINOPEL IM JAHRE 1851 : MIT 71 ABBILDUNGEN, EINEM PLANE VON JERUSALEM UND EINER CHARTE VON PALÄSTINA UND EINEM THEILE AEGYPTENS. Reisen in das heilige Land, nach Smyrna, Beirut, Constantinopel, Alexandrien und Cairo, in den Jahren 1851, 1856 und 1857 : In zwei Theilen / von Theodor Fliedner, Dr. der Theologie, Pfarrer und Inspektor der Diakonissen-Anstalt zu Kaiserswerth (-) Reise mit 4 Diakonissen in das h. Land, nach Smyrna, Beirut und Constantinopel im Jahre 1851 : Mit 71 Abbildungen, einem Plane von Jerusalem und einer Charte von Palästina und einem Theile Aegyptens. (Theil 1) (1) Einband (1) Frontispiz / Titelseite (4) Vorwort. (5) Inhalt des ersten Theils. (6) Text (7) Anhang. (208) Sach-Register. (210) Verzeichniß der Abbildungen. (212) Plan von Jerusalem. (213) Karte von Palaestina und einem Theil Aegyptens. (214

Medical management of radiation accidents - manual on the acute radiation syndrome

In the Nuclear Fission Safety Program (DG XII Science) of the European Atomic Energy Community, the Commission of the European Communities accepted and supported a Concerted Action called "Medical Treatment Protocols for Radiation Accident Victims as a Basis for a Computerized Guidance System", in short METREPOL (Contract number FI4PCT970067). The work of the Concerted Action started in December 1997. One of the main purposes of this interdisciplinary project was to develop a new approach in the medical management of radiation accidents with respect to diagnostic procedures and therapeutic options based on the recognition and evaluation of health impairments after acute radiation exposure. The work of the group is presented in the form of this manual on the acute radiation syndrome. The acute radiation syndrome (ARS) is very complex, because the interactions and combined effects of damage to different organ systems after radiation exposure are diverse and not yet fully understood. Furthermore, the clinical management of patients suffering from an ARS requires immediate and specialized care. In cases of accidental exposure to ionizing radiation, guidance for appropriate diagnostic and therapeutic procedures is therefore required. This manual is compiled to help assess in the shortest time possible the state and possible outcome of radiation accident victims. It specifies what has to be examined and what should be documented, and it provides a scientific basis for deciding the most appropriate therapeutic interventions