Predictors of long-term memory and network connectivity 10 years after anterior temporal lobe resection.

OBJECTIVE Anterior temporal lobe resection (ATLR) effectively controls seizures in medically refractory temporal lobe epilepsy but risks significant episodic memory decline. Beyond 1 year postoperatively, the influence of preoperative clinical factors on episodic memory and long-term network plasticity remain underexplored. Ten years post-ATLR, we aimed to determine biomarkers of successful memory network reorganization and establish presurgical features' lasting impact on memory function. METHODS Twenty-five ATLR patients (12 left-sided) and 10 healthy controls underwent a memory-encoding functional magnetic resonance imaging paradigm alongside neuropsychometry 10 years postsurgery. Generalized psychophysiological interaction analyses modeled network functional connectivity of words/faces remembered, seeding from the medial temporal lobes (MTLs). Differences in successful memory connectivity were assessed between controls and left/right ATLR. Multivariate regressions and mixed-effect models probed preoperative phenotypes' effects on long-term memory outcomes. RESULTS Ten years post-ATLR, lower baseline functioning (verbal and performance intelligence quotient) and a focal memory impairment preoperatively predicted worse long-term memory outcomes. Poorer verbal memory was significantly associated with longer epilepsy duration and earlier onset age. Relative to controls, successful word and face encoding involved increased functional connectivity from both or remnant MTL seeds and contralesional parahippocampus/hippocampus after left/right ATLR. Irrespective of surgical laterality, successful memory encoding correlated with increased MTL-seeded connectivity to frontal (bilateral insula, right anterior cingulate), right parahippocampal, and bilateral fusiform gyri. Ten years postsurgery, better memory performance was correlated with contralateral frontal plasticity, which was disrupted with longer epilepsy duration. SIGNIFICANCE Our findings underscore the enduring nature of functional network reorganizations to provide long-term cognitive support. Ten years post-ATLR, successful memory formation featured stronger connections near resected areas and contralateral regions. Preoperative network disruption possibly influenced effectiveness of postoperative plasticity. These findings are crucial for enhancing long-term memory prediction and strategies for lasting memory rehabilitation

Géoarchéologie des îles de la Méditerranée

Parmi les dix mille îles et îlots de Méditerranée, moins de trois cents seraient habités et seulement deux cents mesureraient plus de 5 km2. Ces îles sont des entités géologiques et géographiques complexes où coexistent des formations de roches très anciennes et d'autres créées très récemment (îles volcaniques). A la fois ouvertes sur l'horizon et les côtes continentales voisines, elles restent, paradoxalement, relativement fermées de par leur isolement, créant ainsi des spécificités quant à leur biodiversité et leur colonisation par les sociétés humaines. Les îles de Méditerranée forment ainsi un objet d'étude privilégié pour la géoarchéologie. Celte dernière emprunte les concepts, les méthodes et les techniques de disciplines relevant des sciences humaines et environnementales (l'archéologie, l'épigraphie, la philologie, la géographie. la paléoécologie, la paléontologie...). Cet ouvrage établit un premier état des connaissances dans le domaine de la géoarchéologie des îles de Méditerranée. L'éclatement géographique de ces dernières, ainsi qu'une histoire de l'occupation propre à chacune, démontrent toute la difficulté de globaliser ces espaces géographiques, progressivement transformés en territoires sous l'action répétée des sociétés humaines. Des spécialistes dressent ici les relations complexes entre les dynamiques et les processus paysagers et les logiques d'occupation humaine depuis la fin du Pléistocène. Le présent ouvrage recueille vingt-quatre contributions regroupées dans cinq parties intitulées « Anthropisation et mutations paysagères à la transition Paléolithique/Néolithique » ; « Mobilité et reconstitution des anciens niveaux marins depuis la fin de la dernière grande glaciation quaternaire » ; « Adaptation aux mutations paysagères à l'échelle intra-site : la nécessaire prise en compte des paramètres environnementaux » ; « Deltas, lagunes et marais : des interfaces propices à l'implantation des sociétés humaines » et « Matières premières ; exploitation et interactions ». Cet ouvrage s'adresse principalement à des spécialistes de géographie, d'archéologie et de paléoécologie mais aussi à un public plus large : étudiants des niveaux L-M-D, enseignants et simples néophytes souhaitant s'initier aux concepts, méthodes et techniques de la géoarchéologie

Descriptive epidemiology of 399 histologically confirmed newly diagnosed meningeal solitary fibrous tumours and haemangiopericytomas in France: 2006–2015

International audiencePurpose: Meningeal solitary fibrous tumour (SFT) and haemangiopericytoma (HPC) are uncommon tumours that have been merged into a single entity in the last 2021 WHO Classification of Tumors of the Central Nervous System. To describe the epidemiology of SFT/HPC operated in France and, to assess their incidence.Methods: We processed the French Brain Tumour Database (FBTDB) to conduct a nationwide population-based study of all histopathologically confirmed SFT/HPC between 2006 and 2015.Results: Our study included 399 SFT/HPC patients, operated in France between 2006 and 2015, in one of the 46 participating neurosurgical centres. The incidence reached 0.062, 95%CI[0.056-0.068] for 100,000 person-years. SFT accounted for 35.8% and, HPC for 64.2%. The ratio of SFT/HPC over meningioma operated during the same period was 0.013. SFT/HPC are about equally distributed in women and men (55.9% vs. 44.1%). For the whole population, mean age at surgery was 53.9 (SD ± 15.8) years. The incidence of SFT/HPC surgery increases with the age and, is maximal for the 50-55 years category. Benign SFT/HPC accounted for 65.16%, SFT/HPC of uncertain behaviour for 11.53% and malignant ones for 23.31%. The number of resection progresses as the histopathological behaviour became more aggressive. 6.7% of the patients with a benign SFT/HPC had a second surgery vs.16.6% in case of uncertain behaviour and, 28.4% for malignant SFT/HPC patients.Conclusion: Meningeal SFT and HPC are rare CNS mesenchymal tumours which both share common epidemiological characteristics, asserting their merging under a common entity. SFT/HPC incidence is less that one case for 1 billion per year and, for around 100 meningiomas-like tumours removed, one SFT/HPC may be diagnosed. SFT/HPC are equally distributed in women and men and, are mainly diagnosed around 50-55 years. The more aggressive the tumour, the higher the probability of recurrence