An in-depth analysis of the health and wellbeing of individuals with autism spectrum disorder

Over five studies, this thesis aimed to investigate the overall health and wellbeing of individuals with autism spectrum disorder (ASD). The primary objectives were to: (a) explore the areas of concern among individuals with ASD across the spectrum; (b) understand the differences pertaining to the overall health, social and motor functioning between high functioning and low functioning individuals; (c) understand the sex differences pertaining to the overall health, social, and motor functioning among high and low functioning individuals with ASD; (d) gain in-depth detail regarding the social and motor functioning of children and youth with ASD through the perspectives of caregivers; and (e) examine the association between imitation, social, and motor performance in individuals with ASD. Findings showed that individuals with ASD experience many issues, namely, health, social, and motor issues. These issues vary depending on the level of functioning of individuals, but not the sex of the individuals. Findings further indicated a reciprocal relationship between social and motor functioning, as well as, imitation and motor performance. In addition to providing further insight into the challenges individuals with ASD experience, this thesis offers many well-informed credible suggestions that warrant the attention of health care professionals, caregivers, family members, the school system, and researchers

An in-depth analysis of the health and wellbeing of individuals with autism spectrum disorder

Over five studies, this thesis aimed to investigate the overall health and wellbeing of individuals with autism spectrum disorder (ASD). The primary objectives were to: (a) explore the areas of concern among individuals with ASD across the spectrum; (b) understand the differences pertaining to the overall health, social and motor functioning between high functioning and low functioning individuals; (c) understand the sex differences pertaining to the overall health, social, and motor functioning among high and low functioning individuals with ASD; (d) gain in-depth detail regarding the social and motor functioning of children and youth with ASD through the perspectives of caregivers; and (e) examine the association between imitation, social, and motor performance in individuals with ASD. Findings showed that individuals with ASD experience many issues, namely, health, social, and motor issues. These issues vary depending on the level of functioning of individuals, but not the sex of the individuals. Findings further indicated a reciprocal relationship between social and motor functioning, as well as, imitation and motor performance. In addition to providing further insight into the challenges individuals with ASD experience, this thesis offers many well-informed credible suggestions that warrant the attention of health care professionals, caregivers, family members, the school system, and researchers

Improving efficiency in generating submissions and consistency of outcomes for Marine Stewardship Council (MSC) based assessments

The prevalence of fishery certification schemes and associated ecolabels has grown over the last ten years with numerous ecolabels now in the marketplace e.g. Friends of the Sea, Naturland, SAI Global Trust (Parkes et al. 2010, Washington and Ababouch 2011, Ward and Phillips 2013). However, one of the most prominent and well regarded, particularly by eNGOs, is the Marine Stewardship Council (MSC) (Gutiérrez et al. 2012, Ponte 2012, Bush et al. 2013, Ward and Phillips 2013) which accounts for greater than 10 % of annual global harvest of wild capture fisheries (MSC 2014b)

Tribal Disruption and Indian Claims

Legal claims are inherently disruptive. Plaintiffs\u27 suits invariably seek to unsettle the status quo. On occasion, the remedies to legal claims can be so disruptive-that is, impossible to enforce or implement in a fair and equitable manner-that courts simply will not issue them. In the area of federal Indian law, American Indian tribal claims not only disrupt the status quo but may even disrupt so-called settled expectations of those affected by the claims. The U.S. Court of Appeals for the Second Circuit has dismissed a round of Indian land claims at the pleading stage, includingOnondaga Nation v. New York, because it considered the claims so disruptive. We agree that Indian legal claims are inherently disruptive and may implicate the centuries-old settled expectations of state and local governments and non-Indians. It is empirically and categorically false, however, that the remedies tribal interests seek are impossible to enforce or implement in a fair or equitable manner. Every year in cases against state governments and their political subdivisions, Indian tribes settle long-standing claims that at their outset, often appear intractable, if not downright impossible, to remedy. The recent settlements of claims by the Oneida Indian Nation of New York, the Saginaw Chippewa Indian Tribe, and five Michigan Anishinaabe tribes demonstrate the falsehood of the idea that Indian claims are too disruptive to be remedied. These negotiated settlements powerfully illustrate that the disruption produced by Indian claims has an important function: forcing federal, state, and tribal governments to creatively seek solutions to difficult governance issues in Indian country

Pilbara steer growth evaluation : 1994 - 1996

Growth potential of steers in the Pilbara - a summary. The trial was conducted over a range of conditions on three locations. The pasture type at Wyloo, the Ashburton River frontage, which is regarded as one of the most productive pasture types in the area, combined with conservative stocking, a fresh paddock and excellent seasonal conditions during 1995, gives us an indication of the District\u27s potential. In extrapolating any of these data to other cases, consideration must be given to adjustment bas

Tribal Disruption and Indian Claims

Legal claims are inherently disruptive. Plaintiffs\u27 suits invariably seek to unsettle the status quo. On occasion, the remedies to legal claims can be so disruptive-that is, impossible to enforce or implement in a fair and equitable manner-that courts simply will not issue them. In the area of federal Indian law, American Indian tribal claims not only disrupt the status quo but may even disrupt so-called settled expectations of those affected by the claims. The U.S. Court of Appeals for the Second Circuit has dismissed a round of Indian land claims at the pleading stage, includingOnondaga Nation v. New York, because it considered the claims so disruptive. We agree that Indian legal claims are inherently disruptive and may implicate the centuries-old settled expectations of state and local governments and non-Indians. It is empirically and categorically false, however, that the remedies tribal interests seek are impossible to enforce or implement in a fair or equitable manner. Every year in cases against state governments and their political subdivisions, Indian tribes settle long-standing claims that at their outset, often appear intractable, if not downright impossible, to remedy. The recent settlements of claims by the Oneida Indian Nation of New York, the Saginaw Chippewa Indian Tribe, and five Michigan Anishinaabe tribes demonstrate the falsehood of the idea that Indian claims are too disruptive to be remedied. These negotiated settlements powerfully illustrate that the disruption produced by Indian claims has an important function: forcing federal, state, and tribal governments to creatively seek solutions to difficult governance issues in Indian country

Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages.

Bisphosphonates drugs target the skeleton and are used globally for the treatment of common bone disorders. Nitrogen-containing bisphosphonates act by inhibiting the mevalonate pathway in bone-resorbing osteoclasts but, surprisingly, also appear to reduce the risk of death from pneumonia. We overturn the long-held belief that these drugs act only in the skeleton and show that a fluorescently labelled bisphosphonate is internalised by alveolar macrophages and large peritoneal macrophages in vivo. Furthermore, a single dose of a nitrogen-containing bisphosphonate (zoledronic acid) in mice was sufficient to inhibit the mevalonate pathway in tissue-resident macrophages, causing the build-up of a mevalonate metabolite and preventing protein prenylation. Importantly, one dose of bisphosphonate enhanced the immune response to bacterial endotoxin in the lung and increased the level of cytokines and chemokines in bronchoalveolar fluid. These studies suggest that bisphosphonates, as well as preventing bone loss, may boost immune responses to infection in the lung and provide a mechanistic basis to fully examine the potential of bisphosphonates to help combat respiratory infections that cause pneumonia