Ten Quick Tips for Using a Raspberry Pi

Much of biology (and, indeed, all of science) is becoming increasingly computational. We tend to think of this in regards to algorithmic approaches and software tools, as well as increased computing power. There has also been a shift towards slicker, packaged solutions--which mirrors everyday life, from smart phones to smart homes. As a result, it's all too easy to be detached from the fundamental elements that power these changes, and to see solutions as "black boxes". The major goal of this piece is to use the example of the Raspberry Pi--a small, general-purpose computer--as the central component in a highly developed ecosystem that brings together elements like external hardware, sensors and controllers, state-of-the-art programming practices, and basic electronics and physics, all in an approachable and useful way. External devices and inputs are easily connected to the Pi, and it can, in turn, control attached devices very simply. So whether you want to use it to manage laboratory equipment, sample the environment, teach bioinformatics, control your home security or make a model lunar lander, it's all built from the same basic principles. To quote Richard Feynman, "What I cannot create, I do not understand".Comment: 12 pages, 2 figure

Sense of agency, associative learning, and schizotypy

Despite the fact that the role of learning is recognised in empirical and theoretical work on sense of agency (SoA), the nature of this learning has, rather surprisingly, received little attention. In the present study we consider the contribution of associative mechanisms to SoA. SoA can be measured quantitatively as a temporal linkage between voluntary actions and their external effects. Using an outcome blocking procedure, it was shown that training action-outcome associations under conditions of increased surprise augmented this temporal linkage. Moreover, these effects of surprise were correlated with schizotypy scores, suggesting that individual differences in higher level experiences are related to associative learning and to its impact on SoA. These results are discussed in terms of models of SoA, and our understanding of disrupted SoA in certain disorders

Comparison of Volumetric Analysis Methods for Machine Tools with Rotary Axes

Confidence in the ability of a production machine to meet manufacturing tolerances requires a full understanding of the accuracy of the machine. However, the definition of “the accuracy of the machine” is open to interpretation. Historically, this has been in terms of linear positioning accuracy of an axis with no regard for the other errors of the machine. Industry awareness of the three-dimensional positioning accuracy of a machine over its working envelope has slowly developed to an extent that people are aware that “volumetric accuracy” gives a better estimation of machine performance. However, at present there is no common standard for volumetric errors of machine tools, although several researchers have developed models to predict the effect of the combined errors. The error model for machines with three Cartesian axes has been well addressed, for example by the use of homogenous transformation matrices. Intuitively, the number of error sources increases with the number of axes present on the machine. The effect of the individual axis geometric errors can become increasingly significant as the chain of dependent axes is extended. Measurement of the “volumetric error” or its constituents is often restricted to a subset of the errors of the Cartesian axes by solely relying on a laser interferometer for measurement. This leads to a volumetric accuracy figure that neglects the misalignment errors of rotary axes. In more advanced models the accuracy of the rotary axes are considered as a separate geometric problem whose volumetric accuracy is then added to the volumetric accuracy of the Cartesian axes. This paper considers the geometric errors of some typical machine configurations with both Cartesian and non-Cartesian axes and uses case studies to emphasise the importance of measurement of all the error constituents. Furthermore, it shows the misrepresentation when modelling a five-axis machine as a three-plus-two error problem. A method by which the five-axis model can be analysed to better represent the machine performance is introduced. Consideration is also given for thermal and non-rigid influences on the machine volumetric accuracy analysis, both in terms of the uncertainty of the model and the uncertainty during the measurement. The magnitude of these errors can be unexpectedly high and needs to be carefully considered whenever testing volumetric accuracy, with additional tests being recommended

Preparation and synthetic use of heterobimetallic alkyne complexes

This thesis describes the use of heterobimetallic alkyne complexes for use in an efficient stereoselective variant of the Pauson–Khand reaction. Unlike previous protocols found in the literature the source of chiral control upon cyclisation arises solely from the inherently chiral CoMoC2 core of these complexes and not from an external source. The inherently chiral Co(CO)3MoCp(CO)2- and desymmetrised Co2(CO)5(PPh3)–alkyne complexes were utilised as efficient chiral auxiliaries for nucleophilic additions to remote centres of complexed propargylic aldehydes to form secondary propargyl alcohols with a degree of diastereocontrol. A new procedure for the preparation of Co(CO)3MoCp(CO)2–alkyne complexes has also been addressed in which an adaptation of previously known methodology was devised for rapid and robust synthesis negating specialist techniques and procedures. The diastereoselective complexation of Co2(CO)7(PPh3) with a range of chiral alkynols has also been demonstrated with the view to bring about a stereoselective catalytic PK reaction procedure. Chapter 1 [is] an overview to the uses of dicobalt–alkyne complexes in the literature and developments in this field Chapter 2 highlights our research into the use of heterobimetallic-alkyne complexes for use in organic synthesis. Chapter 3 provides experimental data for our studies

More than energy cost: Multiple benefits of the long Achilles tendon in human walking and running

Elastic strain energy that is stored and released from long, distal tendons such as the Achilles during locomotion allows for muscle power amplification as well as for reduction of the locomotor energy cost: as distal tendons perform mechanical work during recoil, plantar flexor muscle fibres can work over smaller length ranges, at slower shortening speeds, and at lower activation levels. Scant evidence exists that long distal tendons evolved in humans (or were retained from our more distant Hominoidea ancestors) primarily to allow high muscle–tendon power outputs, and indeed we remain relatively powerless compared to many other species. Instead, the majority of evidence suggests that such tendons evolved to reduce total locomotor energy cost. However, numerous additional, often unrecognised, advantages of long tendons may speculatively be of greater evolutionary advantage, including the reduced limb inertia afforded by shorter and lighter muscles (reducing proximal muscle force requirement), reduced energy dissipation during the foot–ground collisions, capacity to store and reuse the muscle work done to dampen the vibrations triggered by foot–ground collisions, reduced muscle heat production (and thus core temperature), and attenuation of work-induced muscle damage. Cumulatively, these effects should reduce both neuromotor fatigue and sense of locomotor effort, allowing humans to choose to move at faster speeds for longer. As these benefits are greater at faster locomotor speeds, they are consistent with the hypothesis that running gaits used by our ancestors may have exerted substantial evolutionary pressure on Achilles tendon length. The long Achilles tendon may therefore be a singular adaptation that provided numerous physiological, biomechanical, and psychological benefits and thus influenced behaviour across multiple tasks, both including and additional to locomotion. While energy cost may be a variable of interest in locomotor studies, future research should consider the broader range of factors influencing our movement capacity, including our decision to move over given distances at specific speeds, in order to understand more fully the effects of Achilles tendon function as well as changes in this function in response to physical activity, inactivity, disuse and disease, on movement performance

Interprofessional collaboration in sports medicine : findings from a scoping review

BACKGROUND Sports medicine has grown from a special interest area in healthcare to an established profession in its own right. Containing many specialties and a range of professional inputs there are complex dynamics at work which often dictate the provision of care. Whilst interprofessional interventions have been successfully applied in more mainstream healthcare contexts there has been no equivalent application in sports medicine. PURPOSE We seek to map the literature to explore interprofessional collaboration, interaction and tension in sports medicine. METHOD The study utilised a scoping review methodology followed by a thematic analysis. DISCUSSION & CONCLUSIONS The review located 13 studies which provided an insight into a number of key themes which affect interprofessional collaboration (IPC) in a variety of athletic contexts. All of these themes relate to IPC. The structured introduction of interprofessional education programmes for sports medicine professionals and others, will enable a response to the numerous challenges identified in the review

Health care as a team sport? - Studying athletics to improve interprofessional collaboration

Organizations value teamwork and collaboration as they strive to build culture and attain their goals and objectives. Sports provide a useful and easily accessible means to study teamwork. Interprofessional collaborative practice (IPCP) has been identified as a means of improving patient and population health outcomes. Principles of teamwork in sports can inform health professionals and organizations regarding possible improvement strategies and barriers in the optimization of IPCP. Twenty-eight delegates from the 2017 All Together Better Health Conference in Oxford, UK participated in a World Café to discuss the how teamwork in sports can inform IPCP in healthcare and sports medicine. These discussions were captured, transcribed and coded using the domains developed by the Interprofessional Education Collaborative (IPEC) along with extrapersonal or interpersonal loci. Extrapersonal factors regarding structure of leadership, roles and organizational commitment can be positive factors to promote teamwork. However, interpersonal factors affecting communication, values and lack of commitment to collaboration can serve as barriers. Athletic trainers and other sports medicine professionals can serve as valuable members of interprofessional teams and teamwork is essential in the field of sports medicine